Abstract:
:Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 is ubiquitously expressed at saccular stage in the developing lung. At E18.5, Fstl1 expression is robust in most type of mesenchymal cells, including airway smooth muscle cells surrounding airways, vascular smooth muscle cells, endothelial cells, and vascular pericytes from blood vessel, but not PDGFRα+ fibroblasts in the distal alveolar sacs. Meanwhile, relative weak and sporadic signals of Fstl1 expression are observed in epithelium, including a subgroup of club cells in proximal airways and a few type II alveolar epithelial cells in distal airways. Our data help to understand the critical role of Fstl1 in lung development and lung disease pathogenesis.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Liu X,Liu Y,Yang Z,Ning Wdoi
10.1007/s10735-018-9780-5subject
Has Abstractpub_date
2018-08-01 00:00:00pages
399-409issue
4eissn
1567-2379issn
1567-2387pii
10.1007/s10735-018-9780-5journal_volume
49pub_type
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journal_title:Journal of molecular histology
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