Expression of AQP6 and AQP8 in epithelial ovarian tumor.

Abstract:

:Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differences of aquaporin 6 (AQP6) and aquaporin 8 (AQP8) in epithelial ovarian tumors. The expression of AQP6 and AQP8 in 47 cases of epithelial ovarian tumors were measured by immunochemical technique and Western blotting. AQP6 was strongly expressed in benign ovarian tumors, but weak signal was shown in malignant tumors. The difference was not statistically significant (P > 0.05). Compared with serous adenoma and normal tissues, AQP6 expression in serous carcinoma was obviously decreased (P < 0.05). AQP8 expressions were both identified in benign and malignant tumors, but there was no significantly statistical difference (P > 0.05). For patients with large volume of malignant ascites (>1000 ml), AQP8 expression was increased (P < 0.05). AQP8 expression in malignant tumors was not related to different clinical stages, presence of lymphatic metastasis, and differentiation degrees (P > 0.05). These data showed that AQP6 and AQP8 had different expression degrees in epithelial ovarian tissues, which suggests that AQP6 and AQP8 may play certain roles in epithelial ovarian tumors.

journal_name

J Mol Histol

authors

Ma J,Zhou C,Yang J,Ding X,Zhu Y,Chen X

doi

10.1007/s10735-016-9657-4

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

129-34

issue

2

eissn

1567-2379

issn

1567-2387

pii

10.1007/s10735-016-9657-4

journal_volume

47

pub_type

杂志文章
  • Canonical Wnt signaling activity during synovial joint development.

    abstract::Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signa...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-009-9242-1

    authors: Yamagami T,Molotkov A,Zhou CJ

    更新日期:2009-08-01 00:00:00

  • The role of Cyclin G1 in cellular proliferation and apoptosis of human epithelial ovarian cancer.

    abstract::Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-015-9622-7

    authors: Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

    更新日期:2015-06-01 00:00:00

  • Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors.

    abstract::The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-019-09849-5

    authors: Ahmed A,Gulino A,Amayo S,Arancio W,Florena AM,Belmonte B,Jurjus A,Leone A,Miletich I

    更新日期:2020-02-01 00:00:00

  • Tissue microarrays as a platform for proteomic investigation.

    abstract::Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-006-9049-2

    authors: Chung JY,Braunschweig T,Tuttle K,Hewitt SM

    更新日期:2007-05-01 00:00:00

  • Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues.

    abstract::Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-013-9496-5

    authors: Fam HK,Chowdhury MK,Walton C,Choi K,Boerkoel CF,Hendson G

    更新日期:2013-08-01 00:00:00

  • Rosuvastatin beneficially alters the glomerular structure of kidneys from spontaneously hypertensive rats (SHRs).

    abstract::The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-011-9336-4

    authors: de Barros EP,Garcia-Pinto AB,Machado PY,dos Santos Pereira MJ,de Carvalho JJ

    更新日期:2011-08-01 00:00:00

  • ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis.

    abstract::As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. LncRNA LBX2-AS1 was identified to be an oncogene in some cancers, but the role of ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-020-09921-5

    authors: Gu H,Lin R,Zheng F,Zhang Q

    更新日期:2021-02-01 00:00:00

  • Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells.

    abstract::Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-008-9193-y

    authors: Akiyama T,Sadahira Y,Matsubara K,Mori M,Igarashi Y

    更新日期:2008-10-01 00:00:00

  • Melatonin preconditioning of bone marrow-derived mesenchymal stem cells promotes their engraftment and improves renal regeneration in a rat model of chronic kidney disease.

    abstract::Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-019-09812-4

    authors: Saberi K,Pasbakhsh P,Omidi A,Borhani-Haghighi M,Nekoonam S,Omidi N,Ghasemi S,Kashani IR

    更新日期:2019-04-01 00:00:00

  • Osteogenic and angiogenic characterization of mandible and femur osteoblasts.

    abstract::Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-019-09810-6

    authors: Yang X,Jiang J,Zhou L,Wang S,He M,Luo K,Chen Y,Xu X

    更新日期:2019-04-01 00:00:00

  • MRP1 knockdown down-regulates the deposition of collagen and leads to a reduced hypertrophic scar fibrosis.

    abstract::Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-015-9629-0

    authors: Li Y,Yang L,Zheng Z,Shi J,Wu X,Guan H,Jia Y,Tao K,Wang H,Han S,Gao J,Zhao B,Su L,Hu D

    更新日期:2015-10-01 00:00:00

  • Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues.

    abstract::MI-ER1 is a novel transcriptional regulator that plays a critical role in embryonic development and is differentially expressed in breast carcinoma. The MI-ER1 protein sequence is highly conserved among species, with 95% identity between mouse and humans and 72% between Xenopus and mouse. There are two major protein i...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-007-9116-3

    authors: Thorne LB,McCarthy PL,Paterno GD,Gillespie LL

    更新日期:2008-02-01 00:00:00

  • Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.

    abstract::The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-011-9323-9

    authors: Miranda SR,Noguti J,Carvalho JG,Oshima CT,Ribeiro DA

    更新日期:2011-04-01 00:00:00

  • Temporal and functional changes in glycosaminoglycan expression during osteogenesis.

    abstract::Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-007-9123-4

    authors: Nurcombe V,Goh FJ,Haupt LM,Murali S,Cool SM

    更新日期:2007-10-01 00:00:00

  • Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

    abstract::Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-018-9806-z

    authors: Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

    更新日期:2019-02-01 00:00:00

  • Molecular evaluation of chronic restrain stress in mice model of non metastatic fibrosarcoma.

    abstract::Chronic stress is regarded as a significant factor in the etiology of the many diseases. Numerous methods have been developed through which the effect of chronic stress is examined. The aim of this study is to demonstrate the new experimental model for analysis of immuno-suppression induced by chronic restraint stress...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-020-09886-5

    authors: Smieško G,Banović P,Gusman V,Simin V,Cimpean AM,Lalošević D

    更新日期:2020-08-01 00:00:00

  • CNS neurotrophins are biologically active and expressed by multiple cell types.

    abstract::Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-004-0778-9

    authors: Riley CP,Cope TC,Buck CR

    更新日期:2004-11-01 00:00:00

  • Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.

    abstract::Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-019-09822-2

    authors: Wu J,Wang Q,Han Q,Zhu H,Li M,Fang Y,Wang X

    更新日期:2019-06-01 00:00:00

  • Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation.

    abstract::Submandibular gland (SMG) autotransplantation is an effective therapy for treating severe dry eye syndrome. However, epiphora occurs in more than 40% of patients 6 months after operation. We previously found that muscarinic acetylcholine receptor (mAChR) plays a crucial role in regulating SMG secretion partially throu...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-016-9709-9

    authors: Yang NY,Ding C,Li J,Zhang Y,Xiang RL,Wu LL,Yu GY,Cong X

    更新日期:2017-04-01 00:00:00

  • Short-term administration of non-selective and selective COX-2 NSAIDs do not interfere with bone repair in rats.

    abstract::Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-008-9176-z

    authors: Matsumoto MA,De Oliveira A,Ribeiro Junior PD,Nary Filho H,Ribeiro DA

    更新日期:2008-08-01 00:00:00

  • Semaphorin 3A gets involved in the establishment of mouse tooth eruptive pathway.

    abstract::The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-019-09838-8

    authors: Yu X,Zheng F,Du Y,Tang K,Wang W,Zhang S

    更新日期:2019-10-01 00:00:00

  • Aging up-regulates ARA55 in stromal cells, inducing androgen-mediated prostate cancer cell proliferation and migration.

    abstract::Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-016-9679-y

    authors: Zou Q,Cui D,Liang S,Xia S,Jing Y,Han B

    更新日期:2016-06-01 00:00:00

  • A new approach for examining the neurovascular structure with phalloidin and calcitonin gene-related peptide in the rat cranial dura mater.

    abstract::The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-020-09903-7

    authors: Wang J,Xu D,Cui J,Wang S,She C,Wang H,Wu S,Zhang J,Zhu B,Bai W

    更新日期:2020-10-01 00:00:00

  • Expression of inhibin/activin subunits alpha (-alpha), beta A (-beta (A)) and beta B (-beta (B)) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies.

    abstract::During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-006-9029-6

    authors: Mylonas I,Schiessl B,Jeschke U,Vogl J,Makrigiannakis A,Kuhn C,Kunze S,Schulze S,Kainer F,Friese K

    更新日期:2006-01-01 00:00:00

  • Activation of satellite glial cells in trigeminal ganglion following dental injury and inflammation.

    abstract::Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and form a complete envelope around individual sensory neurons in the trigeminal ganglia (TG), which may be involved in modulating neurons in inflammation. The purpose of this study was to determine the effect of dental injury and inflammatio...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-018-9765-4

    authors: Liu H,Zhao L,Gu W,Liu Q,Gao Z,Zhu X,Wu Z,He H,Huang F,Fan W

    更新日期:2018-06-01 00:00:00

  • The spatio-temporal expression pattern of cytoplasmic Cu/Zn superoxide dismutase (SOD1) mRNA during mouse embryogenesis.

    abstract::The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. In this study, the expression patterns of SOD1 mRNA in mouse ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-007-9134-1

    authors: Yon JM,Baek IJ,Lee SR,Jin Y,Kim MR,Nahm SS,Kim JS,Ahn B,Lee BJ,Yun YW,Nam SY

    更新日期:2008-02-01 00:00:00

  • Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat.

    abstract::Osteoprotegerin (OPG) and the receptor activator of nuclear factor (NF)-kB ligand (RANKL) are key regulators of osteoclastogenesis. The present study had the main aim of showing the localization of OPG and RANKL mRNA and protein in serial sections of the rat femurs and tibiae by immunohistochemistry (IHC) and in situ ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-004-3839-1

    authors: Silvestrini G,Ballanti P,Patacchioli F,Leopizzi M,Gualtieri N,Monnazzi P,Tremante E,Sardella D,Bonucci E

    更新日期:2005-02-01 00:00:00

  • Expression and clinical significance of the HIF-1a/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-015-9609-4

    authors: Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

    更新日期:2015-04-01 00:00:00

  • ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma.

    abstract::E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-013-9504-9

    authors: Zhou Y,Lan J,Wang W,Shi Q,Lan Y,Cheng Z,Guan H

    更新日期:2013-10-01 00:00:00

  • Hormonal regulation of uterine natural killer cells in mouse preimplantation uterus.

    abstract::Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章

    doi:10.1007/s10735-010-9256-8

    authors: Kuang H,Peng H,Xu H,Zhang B,Peng J,Tan Y

    更新日期:2010-02-01 00:00:00