Abstract：
:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing and cell survival rate and therapeutic potential in cell-based therapies seems necessary. The purpose of this study is to evaluate the effect of pretreating BMMSCs with melatonin (MT) on the prosurvival and renoprotective of transplanted cells into the irreversible model of unilateral ureteral obstruction. Adult male Sprague-Dawley rats were randomized into four groups: Sham, UUO, UUO + BMMSCs, and UUO + BMMSCs + MT. The results of our study demonstrated that preconditioning with MT enhanced homing of BMMSCs into the injured kidney. MT reduced the number of TUNEL positive transplanted cells in the UUO + BMMSCs + MT group. The UUO + BMMSCs + MT group showed lower expressions of TGF-β1, α-SMA and TNF-α at both gene and protein levels but higher expression of E-cadherin compared with the UUO + BMMSCs group. In addition, MT preconditioned BMMSCs ameliorated basement membrane disruption and histological status of injured renal tubules and also reduced fibrosis in damaged kidneys. In conclusion, our results show that stem cells pretreated by MT may represent a feasible approach for improving the beneficial effects of stem cell therapy and significantly enhance their survival after transplantation to the injured kidney.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Saberi K,Pasbakhsh P,Omidi A,Borhani-Haghighi M,Nekoonam S,Omidi N,Ghasemi S,Kashani IRdoi
10.1007/s10735-019-09812-4subject
Has Abstractpub_date
2019-04-01 00:00:00pages
129-140issue
2eissn
1567-2379issn
1567-2387pii
10.1007/s10735-019-09812-4journal_volume
50pub_type
杂志文章abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-014-9592-1
更新日期：2014-12-01 00:00:00
abstract：:Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...
journal_title：Journal of molecular histology
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doi：10.1007/s10735-020-09930-4
更新日期：2021-01-03 00:00:00
abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...
journal_title：Journal of molecular histology
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doi：10.1007/s10735-019-09849-5
更新日期：2020-02-01 00:00:00
abstract：:The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9336-4
更新日期：2011-08-01 00:00:00
abstract：:E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9504-9
更新日期：2013-10-01 00:00:00
abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9555-y
更新日期：2014-08-01 00:00:00
abstract：:The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09903-7
更新日期：2020-10-01 00:00:00
abstract：:Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differen...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9657-4
更新日期：2016-04-01 00:00:00
abstract：:Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...
journal_title：Journal of molecular histology
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doi：10.1007/s10735-019-09822-2
更新日期：2019-06-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/10.1007/s10735-004-1318-3
更新日期：2004-06-01 00:00:00
abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09918-0
更新日期：2020-12-01 00:00:00
abstract：:TGF-β1, SNAI1 and MMP-9 are implicated in tumor invasion and metastasis. The purpose of this study was to examine TGF-β1, SNAI1 and MMP-9 expression in papillary thyroid carcinoma (PTC), and to assess association of TGF-β1, SNAI1 and MMP-9 expression with several clinicopathological indicators of PTC. TGF-β1, SNAI1 an...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9557-9
更新日期：2014-08-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9116-3
更新日期：2008-02-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-004-2187-5
更新日期：2004-08-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9123-4
更新日期：2007-10-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9049-2
更新日期：2007-05-01 00:00:00
abstract：:Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-008-9176-z
更新日期：2008-08-01 00:00:00
abstract：:Low muscle strength is observed during the peri-and postmenopausal periods, when the secretion of ovarian hormones is drastically reduced. It is also a predictive of adverse health events as well as incident mobility limitation and disability. The objective of the present study is to study the biochemical and the hist...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9326-6
更新日期：2011-06-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09833-z
更新日期：2019-08-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09829-9
更新日期：2019-08-01 00:00:00
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journal_title：Journal of molecular histology
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更新日期：2005-03-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09921-5
更新日期：2021-02-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-005-9003-8
更新日期：2005-06-01 00:00:00
abstract：:Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09934-0
更新日期：2021-01-04 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09926-0
更新日期：2021-02-01 00:00:00
abstract：:Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9679-y
更新日期：2016-06-01 00:00:00
abstract：:Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-004-0778-9
更新日期：2004-11-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9107-4
更新日期：2007-08-01 00:00:00
abstract：:p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carci...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9084-7
更新日期：2007-06-01 00:00:00
abstract：:The aim of this study was to ascertain whether, like many cell types in cartilaginous tissues if type XI collagen was a pericellular component of annulus fibrosus (AF) cells and chondrocytes. Fine fibrillar networks were visualised which were perlecan, HS (MAb 10E4) and type XI collagen positive. Heparitinase-III pre-...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09823-1
更新日期：2019-06-01 00:00:00
