ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by activating the ERK signaling.

abstract：:In the last few decades, several growth factors were identified in the testis of various mammalian species. Growth factors are shown to promote cell proliferation, regulate tissue differentiation, and modulate organogenesis. In the present investigation we have studied the localization of EGF and EGFR in the adult bov...

journal_title：Journal of molecular histology

authors： Kassab M,Abd-Elmaksoud A,Ali MA

更新日期：2007-06-01 00:00:00

abstract：:Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...

journal_title：Journal of molecular histology

authors： Li Y,Yang L,Zheng Z,Shi J,Wu X,Guan H,Jia Y,Tao K,Wang H,Han S,Gao J,Zhao B,Su L,Hu D

更新日期：2015-10-01 00:00:00

abstract：:Low muscle strength is observed during the peri-and postmenopausal periods, when the secretion of ovarian hormones is drastically reduced. It is also a predictive of adverse health events as well as incident mobility limitation and disability. The objective of the present study is to study the biochemical and the hist...

journal_title：Journal of molecular histology

authors： Moustafa AM,Boshra V

更新日期：2011-06-01 00:00:00

abstract：:The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...

journal_title：Journal of molecular histology

authors： Yu X,Zheng F,Du Y,Tang K,Wang W,Zhang S

更新日期：2019-10-01 00:00:00

abstract：:Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...

journal_title：Journal of molecular histology

authors： Vorbrodt AW,Dobrogowska DH,Tarnawski M,Meeker HC,Carp RI

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...

journal_title：Journal of molecular histology

authors： Miranda SR,Noguti J,Carvalho JG,Oshima CT,Ribeiro DA

更新日期：2011-04-01 00:00:00

abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...

journal_title：Journal of molecular histology

authors： Takeyama R,Takekoshi S,Nagata H,Osamura RY,Kawana S

更新日期：2004-02-01 00:00:00

abstract：:In in vitro and in vivo systems, understanding localization and the functional role of ATP is essential, but effective methods to monitor ATP in cells and tissues are limited. Although quinacrine dihydrochloride is a well-known fluorescent dye used to detect ATP, it is limited in its use because it shows non-specific ...

journal_title：Journal of molecular histology

authors： Lee SJ,Rao AS,Shin YH,Chung HJ,Huh Y,Ahn KH,Jung J

更新日期：2013-04-01 00:00:00

abstract：:During transmyocardial revascularization, cellular destruction of cardiomyocytes occurs as a result of the high-energy laser. However, the features of myocardial cellular destruction are unclear. The present study was undertaken to examine the structural characteristics of cell death in the myocardium following transm...

journal_title：Journal of molecular histology

authors： Cherian SM,Bobryshev YV,Tran D,Sivaraman A,Lord RS,Cherian KM

更新日期：2005-05-01 00:00:00

abstract：:Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...

journal_title：Journal of molecular histology

authors： Yang X,Jiang J,Zhou L,Wang S,He M,Luo K,Chen Y,Xu X

更新日期：2019-04-01 00:00:00

abstract：:Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...

journal_title：Journal of molecular histology

authors： Zou Q,Cui D,Liang S,Xia S,Jing Y,Han B

更新日期：2016-06-01 00:00:00

abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

journal_title：Journal of molecular histology

authors： Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

更新日期：2014-08-01 00:00:00

abstract：:E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...

journal_title：Journal of molecular histology

authors： Zhou Y,Lan J,Wang W,Shi Q,Lan Y,Cheng Z,Guan H

更新日期：2013-10-01 00:00:00

abstract：:Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...

journal_title：Journal of molecular histology

authors： Wang X,Liu Q,Kong D,Long Z,Guo Y,Wang S,Liu R,Hai C

更新日期：2020-10-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...

journal_title：Journal of molecular histology

authors： Saberi K,Pasbakhsh P,Omidi A,Borhani-Haghighi M,Nekoonam S,Omidi N,Ghasemi S,Kashani IR

更新日期：2019-04-01 00:00:00

abstract：:Within the reproductive system, oestrogenic stimulation of uterine and pituitary tissue typically causes a proliferative response accompanied by an angiogenic induction of new blood vessels from existing ones, thereby providing nutrients and oxygen to the growing tissue. The pro-oestrogenic pesticide methoxychlor (MXC...

journal_title：Journal of molecular histology

authors： Goldman JM,Murr AS,Buckalew AR,Schmid JE,Abbott BD

更新日期：2004-05-01 00:00:00

abstract：:As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. LncRNA LBX2-AS1 was identified to be an oncogene in some cancers, but the role of ...

journal_title：Journal of molecular histology

authors： Gu H,Lin R,Zheng F,Zhang Q

更新日期：2021-02-01 00:00:00

abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...

journal_title：Journal of molecular histology

authors： Fam HK,Chowdhury MK,Walton C,Choi K,Boerkoel CF,Hendson G

更新日期：2013-08-01 00:00:00

abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

journal_title：Journal of molecular histology

authors： Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

更新日期：2015-06-01 00:00:00

abstract：:Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...

journal_title：Journal of molecular histology

authors： Saisho Y,Harris PE,Butler AE,Galasso R,Gurlo T,Rizza RA,Butler PC

更新日期：2008-10-01 00:00:00

abstract：:Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...

journal_title：Journal of molecular histology

authors： Akiyama T,Sadahira Y,Matsubara K,Mori M,Igarashi Y

更新日期：2008-10-01 00:00:00

abstract：:Osteoprotegerin (OPG) and the receptor activator of nuclear factor (NF)-kB ligand (RANKL) are key regulators of osteoclastogenesis. The present study had the main aim of showing the localization of OPG and RANKL mRNA and protein in serial sections of the rat femurs and tibiae by immunohistochemistry (IHC) and in situ ...

journal_title：Journal of molecular histology

authors： Silvestrini G,Ballanti P,Patacchioli F,Leopizzi M,Gualtieri N,Monnazzi P,Tremante E,Sardella D,Bonucci E

更新日期：2005-02-01 00:00:00

abstract：:Odontogenic keratocysts (OKCs) are jaw cystic lesions which are characterized by local invasion and high recurrence rate. The majority of OKCs are exposed to microorganisms and occur along with focal inflammatory infiltrates. Cyst fluids are biological fluids that contain a large content of cytokines and immune globul...

journal_title：Journal of molecular histology

authors： Man QW,Zhong WQ,Zhao YF,Liu B,Zhao Y

更新日期：2019-08-01 00:00:00

abstract：:The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. In this study, the expression patterns of SOD1 mRNA in mouse ...

journal_title：Journal of molecular histology

authors： Yon JM,Baek IJ,Lee SR,Jin Y,Kim MR,Nahm SS,Kim JS,Ahn B,Lee BJ,Yun YW,Nam SY

更新日期：2008-02-01 00:00:00

abstract：:DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...

journal_title：Journal of molecular histology

authors： Magangane P,Sookhayi R,Govender D,Naidoo R

更新日期：2016-12-01 00:00:00

abstract：:Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...

journal_title：Journal of molecular histology

authors： Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper M

更新日期：2019-12-01 00:00:00

abstract：:Five subtypes of dopamine receptor exist in two subfamilies: two D(1)-like (D(1) and D(5)) and three D(2)-like (D(2), D(3) and D(4)). We produced novel monoclonal antibodies against all three D(2)-like receptors and used them to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line. Most o...

journal_title：Journal of molecular histology

authors： Wolstencroft EC,Simic G,thi Man N,Holt I,Lam le T,Buckland PR,Morris GE

更新日期：2007-08-01 00:00:00

abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...

journal_title：Journal of molecular histology

authors： Ahmed A,Gulino A,Amayo S,Arancio W,Florena AM,Belmonte B,Jurjus A,Leone A,Miletich I

更新日期：2020-02-01 00:00:00

abstract：:The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...

journal_title：Journal of molecular histology

authors： Xu S,Pang L,Liu Y,Lian X,Mo K,Lv R,Zhu H,Lv C,Lin J,Sun J,Xu L,Wang S

更新日期：2019-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the pituitary gland. The objective of this study was to unveil the VEGF subcellular localisation in different pituitary cell types and to evaluate changes in its expression at different time intervals after oestrogen stimulation. A relevant...

journal_title：Journal of molecular histology

authors： Mukdsi JH,De Paul AL,Gutiérrez S,Roth FD,Aoki A,Torres AI

更新日期：2005-10-01 00:00:00