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Localization of the epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in the bovine testis.

Abstract：

:In the last few decades, several growth factors were identified in the testis of various mammalian species. Growth factors are shown to promote cell proliferation, regulate tissue differentiation, and modulate organogenesis. In the present investigation we have studied the localization of EGF and EGFR in the adult bovine testis by means of immunohistochemical method. Our results demonstrated that EGF and EGFR were localized solely to the bovine testicular germ cells (spermatogonia, spermatocytes, and round spermatids). In contrast, the somatic testicular cells (i.e., Sertoli, Leydig, and myofibroblast cells) exhibited no staining affinity. EGF and EGFR were additionally detected in the epithelial lining of straight tubules and rete testis. Interestingly, the distribution of EGF and EGFR in the germ cells was mainly dependent upon the cycle of the seminiferous epithelium since their localization appeared to be preponderant during the spermatogonia proliferation and during the meiotic and spermiogenic processes. In conclusion, such findings may suggest that EGF and EGFR are important paracrine and/or autocrine regulators of spermatogenesis in bovine.

journal_name

J Mol Histol

journal_title

Journal of molecular histology

authors

Kassab M,Abd-Elmaksoud A,Ali MA

doi

10.1007/s10735-007-9089-2

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

207-14

issue

3

eissn

1567-2379

issn

1567-2387

journal_volume

38

pub_type

杂志文章

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