A novel method using an acedan-based Zn(DPA) probe to monitor ATP localization in an in vivo system.

abstract：:Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...

journal_title：Journal of molecular histology

authors： Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper M

更新日期：2019-12-01 00:00:00

abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...

journal_title：Journal of molecular histology

authors： Elfayomy AK,Almasry SM

更新日期：2014-06-01 00:00:00

abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

journal_title：Journal of molecular histology

authors： Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

更新日期：2015-06-01 00:00:00

abstract：:Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used...

journal_title：Journal of molecular histology

authors： Chung JY,Braunschweig T,Tuttle K,Hewitt SM

更新日期：2007-05-01 00:00:00

abstract：:The distribution of molecular components of interendothelial tight junctions (TJs) was studied in rat blood-brain barrier (BBB) microvessels, using immunogold cytochemistry applied to electron microscopy. Samples of rat brains, both normal (unaffected) and osmotically-affected (1, 5, and 30 min after intracarotid infu...

journal_title：Journal of molecular histology

authors： Dobrogowska DH,Vorbrodt AW

更新日期：2004-06-01 00:00:00

abstract：:Under normal homeostasis, melanocyte growth and behaviour is tightly controlled by the surrounding keratinocytes. Keratinocytes regulate melanocyte behaviour through a complex system of paracrine growth factors and cell-cell adhesion molecules. Pathological changes, leading to development of malignant melanoma, upset ...

journal_title：Journal of molecular histology

authors： Haass NK,Smalley KS,Herlyn M

更新日期：2004-03-01 00:00:00

abstract：:During transmyocardial revascularization, cellular destruction of cardiomyocytes occurs as a result of the high-energy laser. However, the features of myocardial cellular destruction are unclear. The present study was undertaken to examine the structural characteristics of cell death in the myocardium following transm...

journal_title：Journal of molecular histology

authors： Cherian SM,Bobryshev YV,Tran D,Sivaraman A,Lord RS,Cherian KM

更新日期：2005-05-01 00:00:00

abstract：:Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...

journal_title：Journal of molecular histology

authors： Mostafa F,Abdel-Moneim A,Abdul-Hamid M,Galaly SR,Mohamed HM

更新日期：2021-01-03 00:00:00

abstract：:S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and S100A9 expression in murine and human bone and cartilage cells. Only S...

journal_title：Journal of molecular histology

authors： Zreiqat H,Howlett CR,Gronthos S,Hume D,Geczy CL

更新日期：2007-10-01 00:00:00

abstract：:Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...

journal_title：Journal of molecular histology

authors： Cai Y,Kirschke CP,Huang L

更新日期：2018-04-01 00:00:00

abstract：:Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...

journal_title：Journal of molecular histology

authors： Dong H,Ji Z,Liu M,Wang Y,Bai X,Wang T,Liu Z,Wu Y,Zhang B,Luo Y,Li Z,Dong M

更新日期：2013-02-01 00:00:00

abstract：:Low muscle strength is observed during the peri-and postmenopausal periods, when the secretion of ovarian hormones is drastically reduced. It is also a predictive of adverse health events as well as incident mobility limitation and disability. The objective of the present study is to study the biochemical and the hist...

journal_title：Journal of molecular histology

authors： Moustafa AM,Boshra V

更新日期：2011-06-01 00:00:00

abstract：:The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...

journal_title：Journal of molecular histology

authors： de Barros EP,Garcia-Pinto AB,Machado PY,dos Santos Pereira MJ,de Carvalho JJ

更新日期：2011-08-01 00:00:00

abstract：:Gekko japonicus undergoes dramatic changes in the caudal spinal cord after tail amputation. The amputation induces cell proliferation in the caudal ependymal tube. We performed hematoxylin and eosin staining at different time points in the regeneration process to investigate the morphological characterization of the r...

journal_title：Journal of molecular histology

authors： Zhou Y,Xu Q,Li D,Zhao L,Wang Y,Liu M,Gu X,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...

journal_title：Journal of molecular histology

authors： Zhang P,Ma XY,Huang DT,Yang XY

更新日期：2020-06-01 00:00:00

abstract：:Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...

journal_title：Journal of molecular histology

authors： Kuang H,Peng H,Xu H,Zhang B,Peng J,Tan Y

更新日期：2010-02-01 00:00:00

abstract：:Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...

journal_title：Journal of molecular histology

authors： Wang X,Liu Q,Kong D,Long Z,Guo Y,Wang S,Liu R,Hai C

更新日期：2020-10-01 00:00:00

abstract：:Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in a...

journal_title：Journal of molecular histology

authors： Slater MD,Murphy CR

更新日期：2006-01-01 00:00:00

abstract：:Immunohistochemical and fluorescent in situ hybridization (FISH) assays are useful diagnostic methods for the identification of bacteria on formalin fixed paraffin embedded histological sections. To validate an anti-bacterial antibody or an oligonucleotide probe and to ensure fidelity during subsequent analyses, suita...

journal_title：Journal of molecular histology

authors： Recordati C,Radaelli E,Simpson KW,Scanziani E

更新日期：2008-08-01 00:00:00

abstract：:Computational modelling of whole biological systems from cells to organs is gaining momentum in cell biology and disease studies. This pathway is essential for the derivation of explanatory frameworks that will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particul...

journal_title：Journal of molecular histology

authors： Moore MN,Noble D

更新日期：2004-09-01 00:00:00

abstract：:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...

journal_title：Journal of molecular histology

authors：

更新日期：2016-04-01 00:00:00

abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...

journal_title：Journal of molecular histology

authors： Kero D,Kalibovic Govorko D,Vukojevic K,Cubela M,Soljic V,Saraga-Babic M

更新日期：2014-12-01 00:00:00

abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...

journal_title：Journal of molecular histology

authors： Ahmed A,Gulino A,Amayo S,Arancio W,Florena AM,Belmonte B,Jurjus A,Leone A,Miletich I

更新日期：2020-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

journal_title：Journal of molecular histology

authors： Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

更新日期：2015-04-01 00:00:00

abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

journal_title：Journal of molecular histology

authors： Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

更新日期：2014-08-01 00:00:00

abstract：:Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...

journal_title：Journal of molecular histology

authors： Matsumoto MA,De Oliveira A,Ribeiro Junior PD,Nary Filho H,Ribeiro DA

更新日期：2008-08-01 00:00:00

abstract：:Spinal cord injury frequently results in permanent loss of neurological function. It includes many complex molecular and biochemical mechanisms. G-protein-coupled receptor kinase 6 (GRK6) is an intracellular kinase that regulates the sensitivity of certain G-protein-coupled receptors. Some studies reported GRK2 and GR...

journal_title：Journal of molecular histology

authors： Sun B,Gao Y,Lou D,Wu X,Wei H,Wen H,Deng X,Zhang F

更新日期：2013-06-01 00:00:00

abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...

journal_title：Journal of molecular histology

authors： Takeyama R,Takekoshi S,Nagata H,Osamura RY,Kawana S

更新日期：2004-02-01 00:00:00

abstract：:The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. HtrA2, a special one, is mainly located in mitochondria and required for maintaining homeostasis. Once released into cytoplasm, H...

journal_title：Journal of molecular histology

authors： Sun H,Li L,Zhou F,Zhu L,Ke K,Tan X,Xu W,Rui Y,Zheng H,Zhou Z,Yang H

更新日期：2013-08-01 00:00:00

abstract：:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and prog...

journal_title：Journal of molecular histology

authors： Li X,Zhang X,Wu CC,Li PP,Fu YM,Xie LH,Sun SS,Zhou YY,Zhu BL

更新日期：2021-02-01 00:00:00