Abstract：
:During transmyocardial revascularization, cellular destruction of cardiomyocytes occurs as a result of the high-energy laser. However, the features of myocardial cellular destruction are unclear. The present study was undertaken to examine the structural characteristics of cell death in the myocardium following transmyocardial revascularization. Myocardial specimens from 3 male patients who had died within 11 days following laser revascularization were collected within 1 h of death and were analyzed by immunohistochemistry and electron microscopy. For immunohistochemistry, antibodies to pro-apoptotic proteins CPP32 and BAX were used. Immunohistochemical examination demonstrated the presence of cells expressing both CPP32 and BAX along the laser channel. Electron microscopic analysis revealed that the lining surface of laser channels consisted of condensed acellular debris and dead cells. No endothelialization of channels was noted. The lumen of laser channels were surrounded by a rim of acellular debris with several outer concentric rims of cardiomyocytes showing features of cellular destruction. The present study identified features of both necrotic and apoptotic cellular death following laser revascularization.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Cherian SM,Bobryshev YV,Tran D,Sivaraman A,Lord RS,Cherian KMdoi
10.1007/s10735-005-5343-7keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
275-80issue
4eissn
1567-2379issn
1567-2387journal_volume
36pub_type
杂志文章abstract：:Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differen...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9657-4
更新日期：2016-04-01 00:00:00
abstract：:Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and form a complete envelope around individual sensory neurons in the trigeminal ganglia (TG), which may be involved in modulating neurons in inflammation. The purpose of this study was to determine the effect of dental injury and inflammatio...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-018-9765-4
更新日期：2018-06-01 00:00:00
abstract：:During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9029-6
更新日期：2006-01-01 00:00:00
abstract：:Objective Oligodendroglial tumors with a loss of heterozygosity of 1p (LOH1p) appear to have a better prognosis than oligodendrogliomas without LOH. Previously, we reported glucose uptake in low-grade oligodendroglial tumors to be related to LOH 1p status. Here, we performed an immunohistochemical study of the common ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-008-9191-0
更新日期：2008-10-01 00:00:00
abstract：:The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9323-9
更新日期：2011-04-01 00:00:00
abstract：:In the original publication of the article, two errors were made in describing the equations for Tc. ...
journal_title：Journal of molecular histology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10735-018-9783-2
更新日期：2018-08-01 00:00:00
abstract：:Estrogens and their receptors are important factors involved in periodontal ligament (PDL) tissue health. As a regulator of estrogen receptors (ER), the proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) may play a role in alveolar bone formation and PDL homeostasis. The aim of the present study was to obser...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9490-y
更新日期：2013-06-01 00:00:00
abstract：:The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. The effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-009-9218-1
更新日期：2009-04-01 00:00:00
abstract：:p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9324-8
更新日期：2011-06-01 00:00:00
abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1023/b:hijo.0000023388.51625.6c
更新日期：2004-02-01 00:00:00
abstract：:p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carci...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9084-7
更新日期：2007-06-01 00:00:00
abstract：:During their commitment and differentiation toward the osteoblast lineage, mesenchymal stem cells secrete a unique extracellular matrix (ECM) that contains large quantities of glycosaminoglycans (GAGs). Proteoglycans (PGs) are major structural and functional components of the ECM and are composed of a core protein to ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9119-0
更新日期：2007-10-01 00:00:00
abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09849-5
更新日期：2020-02-01 00:00:00
abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09918-0
更新日期：2020-12-01 00:00:00
abstract：:The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09833-z
更新日期：2019-08-01 00:00:00
abstract：:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09812-4
更新日期：2019-04-01 00:00:00
abstract：:Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-008-9176-z
更新日期：2008-08-01 00:00:00
abstract：:Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-017-9753-0
更新日期：2018-04-01 00:00:00
abstract：:Histochemical and morphological research increasingly relies upon quantification of complex biological systems. For such investigations to be meaningful, quantification techniques must meet the seemingly conflicting requirements of being theoretically robust, yet sufficiently practical to facilitate widespread applica...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-004-2187-5
更新日期：2004-08-01 00:00:00
abstract：:E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9504-9
更新日期：2013-10-01 00:00:00
abstract：:DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9695-y
更新日期：2016-12-01 00:00:00
abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9555-y
更新日期：2014-08-01 00:00:00
abstract：:Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9026-9
更新日期：2006-01-01 00:00:00
abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-014-9592-1
更新日期：2014-12-01 00:00:00
abstract：:Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...
journal_title：Journal of molecular histology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10735-008-9195-9
更新日期：2008-10-01 00:00:00
abstract：:In order to study the presence of sulphated glycoconjugates in the first mineralised layer juxtaposed to the root dentine (the hyaline layer), we have examined the early stages of molar root development by ultrastructural cytochemistry using Cuprolinic Blue combined with enzymatic pretreatment. Upper molars from 10 to...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1023/b:hijo.0000021089.75408.7c
更新日期：2004-01-01 00:00:00
abstract：:The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09903-7
更新日期：2020-10-01 00:00:00
abstract：:Computational modelling of whole biological systems from cells to organs is gaining momentum in cell biology and disease studies. This pathway is essential for the derivation of explanatory frameworks that will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particul...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-004-2653-0
更新日期：2004-09-01 00:00:00
abstract：AIM:To compare the expression of p57 as indirect marker of genomic imprinting of CDKN1C in a series of infantile hemangiomas (IH) of patients with and without Beckwith-Wiedemann syndrome. MATERIALS AND METHODS:Cases of mammary, salivary gland, liver (one each), and placental (2 cases) capillary hemangiomas all with hi...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-005-2255-5
更新日期：2005-03-01 00:00:00
abstract：:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and prog...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09920-6
更新日期：2021-02-01 00:00:00
