Abstract：
:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized that Tdp1 participates in the repair of mitochondrial DNA. As a step toward testing this hypothesis, we profiled Tdp1 expression in different human tissues by immunohistochemistry and immunofluorescence respectively and determined whether Tdp1 was expressed in the cytoplasm of tissues other than the neurons. We found that Tdp1 was ubiquitously expressed and present in the cytoplasm of many cell types. Within human skeletal muscle and multiple mouse tissues, Tdp1 partially colocalized with the mitochondria. In cultured human dermal fibroblasts, Tdp1 redistributed to the cytoplasm and partially colocalized with mitochondria following oxidative stress. These studies suggest that one role of cytoplasmic Tdp1 is the repair of mitochondrial DNA lesions arising from oxidative stress.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Fam HK,Chowdhury MK,Walton C,Choi K,Boerkoel CF,Hendson Gdoi
10.1007/s10735-013-9496-5subject
Has Abstractpub_date
2013-08-01 00:00:00pages
481-94issue
4eissn
1567-2379issn
1567-2387journal_volume
44pub_type
杂志文章abstract：:The aim of this study was to ascertain whether, like many cell types in cartilaginous tissues if type XI collagen was a pericellular component of annulus fibrosus (AF) cells and chondrocytes. Fine fibrillar networks were visualised which were perlecan, HS (MAb 10E4) and type XI collagen positive. Heparitinase-III pre-...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09823-1
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abstract：:The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9336-4
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-015-9609-4
更新日期：2015-04-01 00:00:00
abstract：:In in vitro and in vivo systems, understanding localization and the functional role of ATP is essential, but effective methods to monitor ATP in cells and tissues are limited. Although quinacrine dihydrochloride is a well-known fluorescent dye used to detect ATP, it is limited in its use because it shows non-specific ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-012-9474-3
更新日期：2013-04-01 00:00:00
abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-014-9592-1
更新日期：2014-12-01 00:00:00
abstract：:Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells mi...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9112-7
更新日期：2007-12-01 00:00:00
abstract：:In the last few decades, several growth factors were identified in the testis of various mammalian species. Growth factors are shown to promote cell proliferation, regulate tissue differentiation, and modulate organogenesis. In the present investigation we have studied the localization of EGF and EGFR in the adult bov...
journal_title：Journal of molecular histology
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
abstract：:The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. In this study, the expression patterns of SOD1 mRNA in mouse ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9134-1
更新日期：2008-02-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09850-y
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journal_title：Journal of molecular histology
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更新日期：2004-09-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9116-3
更新日期：2008-02-01 00:00:00
abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9553-0
更新日期：2014-06-01 00:00:00
abstract：:Five subtypes of dopamine receptor exist in two subfamilies: two D(1)-like (D(1) and D(5)) and three D(2)-like (D(2), D(3) and D(4)). We produced novel monoclonal antibodies against all three D(2)-like receptors and used them to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line. Most o...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9106-5
更新日期：2007-08-01 00:00:00
abstract：:Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09934-0
更新日期：2021-01-04 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9050-9
更新日期：2006-05-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-008-9191-0
更新日期：2008-10-01 00:00:00
abstract：:The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. HtrA2, a special one, is mainly located in mitochondria and required for maintaining homeostasis. Once released into cytoplasm, H...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9489-4
更新日期：2013-08-01 00:00:00
abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09849-5
更新日期：2020-02-01 00:00:00
abstract：:Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...
journal_title：Journal of molecular histology
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doi：10.1007/s10735-019-09822-2
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-012-9466-3
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journal_title：Journal of molecular histology
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journal_title：Journal of molecular histology
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-009-9218-1
更新日期：2009-04-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-015-9629-0
更新日期：2015-10-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9123-4
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journal_title：Journal of molecular histology
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09812-4
更新日期：2019-04-01 00:00:00
abstract：:Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in a...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9027-8
更新日期：2006-01-01 00:00:00
