Fibroblast growth factor signaling regulates neurogenesis at multiple stages in the embryonic olfactory epithelium.

abstract：:Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently,...

journal_title：Stem cells and development

authors： Marfia G,Navone SE,Hadi LA,Paroni M,Berno V,Beretta M,Gualtierotti R,Ingegnoli F,Levi V,Miozzo M,Geginat J,Fassina L,Rampini P,Tremolada C,Riboni L,Campanella R

更新日期：2016-07-15 00:00:00

abstract：:A common observation in metabolic disorders and aging is the elevation of free fatty acids, which can form ectopic fat deposition and result in lipotoxicity. Ectopic fat deposition of skeletal muscle has been recognized as an important component of aging, frailty and sarcopenia. Previous studies have suggested that li...

journal_title：Stem cells and development

authors： Xue M,Zhang F,Ji X,Yu H,Jiang X,Qiu Y,Yu J,Chen J,Yang F,Bao Z

更新日期：2021-01-11 00:00:00

abstract：:The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...

journal_title：Stem cells and development

authors： Rüster B,Grace B,Seitz O,Seifried E,Henschler R

更新日期：2005-04-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells wer...

journal_title：Stem cells and development

authors： Park BW,Pan B,Toms D,Huynh E,Byun JH,Lee YM,Shen W,Rho GJ,Li J

更新日期：2014-07-15 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with significant morbidity and mortality, and it often leads to poor clinical outcome. Although great efforts have been made toward animal and clinical studies, optimal therapy of SAH remains a challenge for scientists and clinicians. Increasing evidence su...

journal_title：Stem cells and development

authors： Song Z,Zhang JH

更新日期：2020-02-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be mobilized from the bone marrow and enter the circulation. Conversely, MSCs can be recruited from the circulation and into the bone marrow. For these migratory pathways, MSCs have to traverse the bone marrow endothelium, in a basal-to-apical and apical-to-basal direction, respective...

journal_title：Stem cells and development

authors： Smith H,Whittall C,Weksler B,Middleton J

更新日期：2012-02-10 00:00:00

abstract：:Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET altered preadipocyte function, enhanced peroxisome proliferation-activated receptor γ coactivator α (PGC-1α) expression, and increased mitocho...

journal_title：Stem cells and development

authors： Waldman M,Bellner L,Vanella L,Schragenheim J,Sodhi K,Singh SP,Lin D,Lakhkar A,Li J,Hochhauser E,Arad M,Darzynkiewicz Z,Kappas A,Abraham NG

更新日期：2016-07-15 00:00:00

abstract：:The corneal endothelium is believed to be developmentally originated from the periocular mesenchyme via the neural crest. Human corneal endothelial progenitor cells (HCEPs) have been investigated because of their potential availability for the tissue regenerative medicine. However, the existence and the properties of ...

journal_title：Stem cells and development

authors： Hara S,Hayashi R,Soma T,Kageyama T,Duncan T,Tsujikawa M,Nishida K

更新日期：2014-09-15 00:00:00

abstract：:Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demo...

journal_title：Stem cells and development

authors： Christensen C,Zhang S,Roelink H

更新日期：2006-10-01 00:00:00

abstract：:Citrin deficiency (CD) is a recessive genetic disorder caused by mutations in the citrin gene SLC25A13. CD causes various symptoms related to nutrient metabolism such as urea cycle failure, abnormal amino acid levels, and fatty liver. To understand the pathophysiology of CD, the molecular phenotypes were investigated ...

journal_title：Stem cells and development

authors： Kim Y,Choi JY,Lee SH,Lee BH,Yoo HW,Han YM

更新日期：2016-04-15 00:00:00

abstract：:Cell-based gene therapy holds a great promise for the treatment of human malignancy. Among different cells, mesenchymal stem cells (MSCs) are emerging as valuable anti-cancer agents that have the potential to be used to treat a number of different cancer types. They have inherent migratory properties, which allow them...

journal_title：Stem cells and development

authors： Nowakowski A,Drela K,Rozycka J,Janowski M,Lukomska B

更新日期：2016-10-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:Human umbilical cord blood (CB) has been used successfully in stem cell transplantation. A subpopulation of CD34(+) cells expresses chemokine receptor CXCR4 which is critical for bone marrow engraftment in human hematopoietic stem cells. Here, we demonstrate the effect of short-term culture on CXCR4 expression on umbi...

journal_title：Stem cells and development

authors： Ohno N,Kajiume T,Sera Y,Sato T,Kobayashi M

更新日期：2009-10-01 00:00:00

abstract：:We describe a method of generating an enriched population of NCAM-positive cells from a human teratocarcinoma cell line (NTera2/D1) and their differentiation into midbrain dopaminergic neurons in the absence of the caudalizing factor retinoic acid (RA). NTera2 cells were induced to form embryoid bodies and then to gen...

journal_title：Stem cells and development

authors： Ravindran G,Rao HS

更新日期：2006-08-01 00:00:00

abstract：:The aim of stem cell therapy after cardiac injury is to replace damaged cardiac tissue. Human cardiac progenitor cells (CPCs) represent an interesting cell population for clinical strategies to treat cardiac disease and human CPC-specific antibodies would aid in the clinical implementation of cardiac progenitor-based ...

journal_title：Stem cells and development

authors： Moerkamp AT,Leung HW,Bax NAM,Holst S,Lodder K,Berends T,Dingenouts CKE,Choo A,Smits AM,Goumans MJ

更新日期：2017-11-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has multiple effects on proliferation and differentiation of human mesenchymal stem cells. Transforming growth factor-activated kinase-1 (TAK1) mediates the activation of nuclear factor-kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways in response to TNF-α. However, the r...

journal_title：Stem cells and development

authors： Lee SY,Lee JH,Shin KK,Kim DS,Kim YS,Bae YC,Jung JS

更新日期：2015-04-01 00:00:00

abstract：:True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology of tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable tendon cell and tissue differentiation based on a...

journal_title：Stem cells and development

authors： Noack S,Seiffart V,Willbold E,Laggies S,Winkel A,Shahab-Osterloh S,Flörkemeier T,Hertwig F,Steinhoff C,Nuber UA,Gross G,Hoffmann A

更新日期：2014-08-15 00:00:00

abstract：:The increasing use of mesenchymal stromal cells (MSC) in clinical cellular therapy requires a safe and controlled production process compliant with Good Manufacturing Practice guidelines. Pooled blood group AB human serum (HS) has been used to replace fetal bovine serum (FBS), critically rated by the regulatory agenci...

journal_title：Stem cells and development

authors： Dreher L,Elvers-Hornung S,Brinkmann I,Huck V,Henschler R,Gloe T,Klüter H,Bieback K

更新日期：2013-03-01 00:00:00

abstract：:The quality of hematopoietic stem cells (HSCs) is essentially defined by two characteristics, i.e., multilineage differentiation and self-renewal capacity. Thus, it is of high priority to clarify mechanisms that regulate these functions and to understand them at the molecular level. In the present study, we investigat...

journal_title：Stem cells and development

authors： Schraml E,Voglauer R,Fortschegger K,Sibilia M,Stelzer I,Grillari J,Schauenstein K

更新日期：2008-04-01 00:00:00

abstract：:Individuals with neurodegenerative disorders or brain injury have few treatment options and it has been proposed that endogenous adult neural stem cells can be harnessed to repopulate dysfunctional nonneurogenic regions of the brain. We have accomplished this through the development of rationally designed hydrogel imp...

journal_title：Stem cells and development

authors： Clark AR,Carter AB,Hager LE,Price EM

更新日期：2016-08-01 00:00:00

abstract：:After intra-articular injection, synovium-derived mesenchymal stem cells (SMSCs) can adhere to damaged cartilage (a process called homing) and then repair the cartilage defect. Nonetheless, the main obstacle of the current method is the insufficient homing ratio of SMSCs, which fails to meet the requirements for carti...

journal_title：Stem cells and development

authors： Liang C,Huang J,Luo P,Wang Z,He J,Wu S,Peng C,Cao X

更新日期：2020-04-01 00:00:00

abstract：:The activation and transcriptional activity of signal transducer and activator of transcription 3 (STAT3) is essential for maintaining mouse embryonic stem (ES) cell cultures in an undifferentiated state. However, reports from human and monkey ES-cell culture suggest that STAT3 is dispensable for pluripotency in these...

journal_title：Stem cells and development

authors： Wagner TU,Kraeussling M,Fedorov LM,Reiss C,Kneitz B,Schartl M

更新日期：2009-01-01 00:00:00

abstract：:The major reservoir of human multipotent mesenchymal stem/stromal cells (MSCs) is the bone marrow (BM) with the capability to control hematopoietic stem cell development. The regenerative potential of MSCs is associated with enhanced endogenous repair and healing mechanisms that modulate inflammatory responses. Our pr...

journal_title：Stem cells and development

authors： Bacskai I,Mázló A,Kis-Tóth K,Szabó A,Panyi G,Sarkadi B,Apáti Á,Rajnavölgyi É

更新日期：2015-08-01 00:00:00

abstract：:As granulocyte-colony-stimulating factor (G-CSF)-induced mobilization of hematopoietic stem/progenitor cells (HSPCs) increases human serum levels of hepatocyte growth factor (HGF), our aim was to investigate the role of HGF and its receptor, c-Met, in the mobilization of HSPC. CD34(+) cells and leukocytes were isolate...

journal_title：Stem cells and development

authors： Jalili A,Shirvaikar N,Marquez-Curtis LA,Turner AR,Janowska-Wieczorek A

更新日期：2010-08-01 00:00:00

abstract：:Stromal cells have been used to induce dopaminergic differentiation of mouse, primate, and human embryonic stem cells (hESCs), but the mechanism that governs this induction is unknown. In this manuscript, we show that medium conditioned by the stromal cell line PA6 (PA6-CM) can induce dopaminergic differentiation in n...

journal_title：Stem cells and development

authors： Swistowska AM,da Cruz AB,Han Y,Swistowski A,Liu Y,Shin S,Zhan M,Rao MS,Zeng X

更新日期：2010-01-01 00:00:00

abstract：:Erythropoietin (Epo) may be considered as an endogenous stimulator of vessel growth during tumor progression through an autocrine and/or paracrine loop. The vascular effects of Epo would be relevant in tumor angiogenesis and the negative effect of Epo on tumor growth may be aggravated by its angiogenic activity. The m...

journal_title：Stem cells and development

authors： Ribatti D

更新日期：2010-01-01 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) was used to analyze peripheral blood stem cells (PBSC) and stem cell assays (SCA) derived from them in 2 patients with acute myeloid leukemia (AML) with trisomy 8 as the sole chromosome abnormality prior to undergoing autologous stem cell transplantation. In both cases, the de...

journal_title：Stem cells and development

authors： Dodge W,Cruz J,Zamkoff K,Hurd D,Pettenati MJ

更新日期：2004-02-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. In this study, we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from random positioning machine (...

journal_title：Stem cells and development

authors： Ratushnyy A,Ezdakova M,Yakubets D,Buravkova L

更新日期：2018-06-15 00:00:00

abstract：:We recently reported the isolation and characterization of a population of pancreatic progenitor cells (PPCs) from early trimester human fetal pancreata. The PPCs, being the forerunners of adult pancreatic cell lineages, were amenable to growth and differentiation into insulin-secreting islet-like cell clusters (ICCs)...

journal_title：Stem cells and development

authors： Leung KK,Suen PM,Lau TK,Ko WH,Yao KM,Leung PS

更新日期：2009-09-01 00:00:00