Redox regulation of canonical Wnt signaling affects extraembryonic endoderm formation.

abstract：:There are a limited number of therapies available to prevent heart failure following myocardial infarction. One novel therapy that is currently being pursued is the implantation of cardiac progenitor cells (CPCs); however, their responses to oxidative stress during differentiation have yet to be elucidated. The object...

journal_title：Stem cells and development

authors： Pendergrass KD,Boopathy AV,Seshadri G,Maiellaro-Rafferty K,Che PL,Brown ME,Davis ME

更新日期：2013-09-01 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) show great potential for clinical and experimental use due to their capacity to self-renew and differentiate into multiple mesenchymal lineages. However, disadvantages of primary cultures of hMSCs are the limited in vitro lifespan, and the variable properties of cells from diffe...

journal_title：Stem cells and development

authors： Skårn M,Noordhuis P,Wang MY,Veuger M,Kresse SH,Egeland EV,Micci F,Namløs HM,Håkelien AM,Olafsrud SM,Lorenz S,Haraldsen G,Kvalheim G,Meza-Zepeda LA,Myklebost O

更新日期：2014-10-01 00:00:00

abstract：:Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET altered preadipocyte function, enhanced peroxisome proliferation-activated receptor γ coactivator α (PGC-1α) expression, and increased mitocho...

journal_title：Stem cells and development

authors： Waldman M,Bellner L,Vanella L,Schragenheim J,Sodhi K,Singh SP,Lin D,Lakhkar A,Li J,Hochhauser E,Arad M,Darzynkiewicz Z,Kappas A,Abraham NG

更新日期：2016-07-15 00:00:00

abstract：:True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology of tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable tendon cell and tissue differentiation based on a...

journal_title：Stem cells and development

authors： Noack S,Seiffart V,Willbold E,Laggies S,Winkel A,Shahab-Osterloh S,Flörkemeier T,Hertwig F,Steinhoff C,Nuber UA,Gross G,Hoffmann A

更新日期：2014-08-15 00:00:00

abstract：:Occupational asthma (OA) is characterized by allergic airway inflammation and hyperresponsiveness, leading to progressive airway remodeling and a concomitant decline in lung function. The management of OA remains suboptimal in clinical practice. Thus, establishing effective therapies might overcome the natural history...

journal_title：Stem cells and development

authors： Martínez-González I,Cruz MJ,Moreno R,Morell F,Muñoz X,Aran JM

更新日期：2014-10-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) have the potential to differentiate into many adult cell types, and they are being explored as a resource for cell replacement therapies for multiple diseases. In order to optimize in vitro differentiation protocols, it will be necessary to elucidate regulatory mechanisms that contri...

journal_title：Stem cells and development

authors： Hinton A,Afrikanova I,Wilson M,King CC,Maurer B,Yeo GW,Hayek A,Pasquinelli AE

更新日期：2010-06-01 00:00:00

abstract：:We recently reported the isolation and characterization of a population of pancreatic progenitor cells (PPCs) from early trimester human fetal pancreata. The PPCs, being the forerunners of adult pancreatic cell lineages, were amenable to growth and differentiation into insulin-secreting islet-like cell clusters (ICCs)...

journal_title：Stem cells and development

authors： Leung KK,Suen PM,Lau TK,Ko WH,Yao KM,Leung PS

更新日期：2009-09-01 00:00:00

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) have been used to treat a variety of autoimmune diseases in clinics. However, the therapeutic effects are largely dependent on the immunomodulatory capacity of culture-expanded BMMSCs. In the present study, we show that aspirin (acetylsalicylic acid, ASA)-treated BMMSCs have...

journal_title：Stem cells and development

authors： Tang J,Xiong J,Wu T,Tang Z,Ding G,Zhang C,Wang S,Liu Y

更新日期：2014-09-01 00:00:00

abstract：:Humans and nonhuman primates (NHPs) are similar in size, behavior, physiology, biochemistry, structure and function of organs, and complexity of the immune system. Research on NHPs generates complementary data that bridge translational research from small animal models to humans. NHP models of human disease offer uniq...

journal_title：Stem cells and development

authors： Daadi MM,Barberi T,Shi Q,Lanford RE

更新日期：2014-12-01 00:00:00

abstract：:Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. However, it is essential to unde...

journal_title：Stem cells and development

authors： Tatebayashi K,Tanaka Y,Nakano-Doi A,Sakuma R,Kamachi S,Shirakawa M,Uchida K,Kageyama H,Takagi T,Yoshimura S,Matsuyama T,Nakagomi T

更新日期：2017-06-01 00:00:00

abstract：:Amniotic fluid stem cells (AFSs) are interesting mesenchymal stem cells (MSCs) that are characterized by their great potential for cell proliferation and differentiation compared with other types of MSCs identified to date. However, MSCs in prolonged culture have been found to exhibit defects in genetic stability and ...

journal_title：Stem cells and development

authors： Phermthai T,Suksompong S,Tirawanchai N,Issaragrisil S,Julavijitphong S,Wichitwiengrat S,Silpsorn D,Pokathikorn P

更新日期：2013-05-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical respiratory failure disorder associated with chronic pathology and disability and has a mortality rate of 40%-60%. However, the pathogenesis of ARDS/ALI remains unclear, and existing therapeutic options are insufficient for address...

journal_title：Stem cells and development

authors： Wang Y,Li H,Li X,Su X,Xiao H,Yang J

更新日期：2021-02-01 00:00:00

abstract：:Primary periodontal ligament stem cells (PDLSCs) are known to possess multidifferentiation potential and exhibit an immunophenotype similar to that described for bone-marrow-derived mesenchymal stem cells. In the present study, bromo-deoxyuridine (BrdU)-labeled ovine PDLSCs implanted into immunodeficient mice survived...

journal_title：Stem cells and development

authors： Menicanin D,Mrozik KM,Wada N,Marino V,Shi S,Bartold PM,Gronthos S

更新日期：2014-05-01 00:00:00

abstract：:Retinoic acid (RA) is present at sites of neurogenesis in both the embryonic and adult brain. While it is widely accepted that RA signaling is involved in the regulation of neural stem cell differentiation, little is known about vitamin A utilization and biosynthesis of active retinoids in the neurogenic niches, or ab...

journal_title：Stem cells and development

authors： Orsolits B,Borsy A,Madarász E,Mészáros Z,Kőhidi T,Markó K,Jelitai M,Welker E,Környei Z

更新日期：2013-10-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) from bone marrow (BM) are widely used for bone and less for cartilage tissue regeneration due to their self-renewal and differentiating properties into osteogenic or chondrogenic lineages. This review considers the last decade of clinical trials involving a two-step procedure, by expandin...

journal_title：Stem cells and development

authors： Veronesi F,Giavaresi G,Tschon M,Borsari V,Nicoli Aldini N,Fini M

更新日期：2013-01-15 00:00:00

abstract：:Osteogenesis imperfecta (OI) is a genetic bone pathology with prenatal onset, characterized by brittle bones in response to abnormal collagen composition. There is presently no cure for OI. We previously showed that human first trimester fetal blood mesenchymal stem cells (MSCs) transplanted into a murine OI model (oi...

journal_title：Stem cells and development

authors： Jones GN,Moschidou D,Abdulrazzak H,Kalirai BS,Vanleene M,Osatis S,Shefelbine SJ,Horwood NJ,Marenzana M,De Coppi P,Bassett JH,Williams GR,Fisk NM,Guillot PV

更新日期：2014-02-01 00:00:00

abstract：:Stem cell-based therapy is a promising treatment for neurodegenerative diseases. In our laboratory, a novel protocol has been developed to induce bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factors- secreting cells (NTF-SC), thus combining stem cell-based therapy with the NTF-based neuroprotecti...

journal_title：Stem cells and development

authors： Sadan O,Bahat-Stromza M,Barhum Y,Levy YS,Pisnevsky A,Peretz H,Ilan AB,Bulvik S,Shemesh N,Krepel D,Cohen Y,Melamed E,Offen D

更新日期：2009-10-01 00:00:00

abstract：:Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by defined factors. However, substantial cell numbers subjected to iPSC induction stray from the main reprogramming route and are immortalized as partial iPSCs. These partial iPSCs can become genuine iPSCs by exposure to the ground state condi...

journal_title：Stem cells and development

authors： Kamon M,Katano M,Hiraki-Kamon K,Hishida T,Nakachi Y,Mizuno Y,Okazaki Y,Suzuki A,Hirasaki M,Ueda A,Nishimoto M,Kato H,Okuda A

更新日期：2014-09-15 00:00:00

abstract：:One of the challenges in stem cell research is to avoid transformation during cultivation. We studied high passage subventricular zone derived neural stem cells (NSCs) cultures of adult rats in the absence of growth factors epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). We termed this culture...

journal_title：Stem cells and development

authors： Kaus A,Widera D,Kassmer S,Peter J,Zaenker K,Kaltschmidt C,Kaltschmidt B

更新日期：2010-07-01 00:00:00

abstract：:In this work, we evaluated the expansion of human hematopoietic stem cells from umbilical cord blood in roller bottles. The Iscove's modified Dulbecco's medium, the Stem Pro 34-SFM medium, and the L-15 Leibovitz's medium for cultures in CO(2)-free atmosphere were assessed. At day 5 of culture, total colony forming uni...

journal_title：Stem cells and development

authors： Andrade-Zaldívar H,Kalixto-Sánchez MA,de la Rosa AP,De León-Rodríguez A

更新日期：2011-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have attracted much attention as potential platforms for transgene delivery and cell-based therapy for human disease. MSCs have the capability to self-renew and retain multipotency after extensive expansion in vitro, making them attractive targets for ex vivo modification and autologous t...

journal_title：Stem cells and development

authors： Ricks DM,Kutner R,Zhang XY,Welsh DA,Reiser J

更新日期：2008-06-01 00:00:00

abstract：:We describe a rapid and efficient 5-step program of defined factors for the genesis of brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells (ESCs). The OLs emerge on the same time frame in vitro as seen in vivo. Factors promoting neural induction (retinoids, noggin) are required, while exogenous Sonic...

journal_title：Stem cells and development

authors： Sadowski D,Kiel ME,Apicella M,Arriola AG,Chen CP,McKinnon RD

更新日期：2010-09-01 00:00:00

abstract：:Traditionally, undifferentiated pluripotent human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) have been expanded as monolayer colonies in adhesion culture, both in the presence or absence of feeder cells. However, the use of pluripotent stem cells poses the need to scale-up current culture methods....

journal_title：Stem cells and development

authors： Larijani MR,Seifinejad A,Pournasr B,Hajihoseini V,Hassani SN,Totonchi M,Yousefi M,Shamsi F,Salekdeh GH,Baharvand H

更新日期：2011-11-01 00:00:00

abstract：:The secretome of human amniotic fluid stem cells (AFSCs) has great potential as a therapeutic agent in regenerative medicine. However, it must be produced in a clinically compliant manner before it can be used in humans. In this study, we developed a means of producing a biologically active secretome from AFSCs that i...

journal_title：Stem cells and development

authors： Mellows B,Mitchell R,Antonioli M,Kretz O,Chambers D,Zeuner MT,Denecke B,Musante L,Ramachandra DL,Debacq-Chainiaux F,Holthofer H,Joch B,Ray S,Widera D,David AL,Huber TB,Dengjel J,De Coppi P,Patel K

更新日期：2017-09-15 00:00:00

abstract：:There is an increasing need for an animal model that can be used to translate basic research into clinical therapy. We documented the differentiation and functional competence of embryonic stem cell (ESC)-derived endothelial cells in baboons. Baboon angioblasts were sequentially differentiated from embryoid body cultu...

journal_title：Stem cells and development

authors： Shi Q,Hodara V,Simerly CR,Schatten GP,VandeBerg JL

更新日期：2013-02-15 00:00:00

abstract：:White matter damage persists in hypoxic-ischemic newborns even when treated with hypothermia. We have previously shown that intraventricular delivery of human glial progenitors (GPs) at the neonatal stage is capable of replacing abnormal host glia and rescuing the lifespan of dysmyelinated mice. However, such transpla...

journal_title：Stem cells and development

authors： Srivastava RK,Jablonska A,Chu C,Gregg L,Bulte JWM,Koehler RC,Walczak P,Janowski M

更新日期：2019-04-15 00:00:00

abstract：:Erythropoietin (Epo) may be considered as an endogenous stimulator of vessel growth during tumor progression through an autocrine and/or paracrine loop. The vascular effects of Epo would be relevant in tumor angiogenesis and the negative effect of Epo on tumor growth may be aggravated by its angiogenic activity. The m...

journal_title：Stem cells and development

authors： Ribatti D

更新日期：2010-01-01 00:00:00

abstract：:Ex vivo cultures of human bone marrow-derived mesenchymal stem cells (MSCs) contain subsets of progenitors exhibiting dissimilar properties. One of these subsets comprises uncommitted progenitors displaying distinctive features, such as morphology, a quiescent condition, growth factor production, and restricted tissue...

journal_title：Stem cells and development

authors： Minguell JJ,Fierro FA,Epuñan MJ,Erices AA,Sierralta WD

更新日期：2005-08-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors are pivotal regulators of cellular differentiation and development. The bHLH factor, Twist-1 has previously been found to control bone marrow stromal/stem cells (BMSC) self-renewal, life span, and differentiation, however not much is known about its mechanism of acti...

journal_title：Stem cells and development

authors： Cakouros D,Isenmann S,Hemming SE,Menicanin D,Camp E,Zannetinno AC,Gronthos S

更新日期：2015-06-01 00:00:00