STAT3 and SMAD1 signaling in Medaka embryonic stem-like cells and blastula embryos.

abstract：:In the past few years research on stem cells has exploded as a tool to develop potential therapies to treat incurable neurodegenerative diseases. Stem cell transplantation has been effective in several animal models, but the underlying restorative mechanisms are still unknown. Several events such as cell fusion, neuro...

journal_title：Stem cells and development

authors： Cova L,Ratti A,Volta M,Fogh I,Cardin V,Corbo M,Silani V

更新日期：2004-02-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Stem cell therapies show great medical promise, but few new products have made it into the marketplace. The translation of stem and other cell therapies faces not only challenges associated with research and development, but also the challenges of investment funding and regulatory approval. Regulators and investors al...

journal_title：Stem cells and development

authors： Plant AL,Parker GC

更新日期：2013-09-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have received great attention due to their remarkable regenerative, angiogenic, antiapoptotic, and immunosuppressive properties. Although conventionally isolated from the bone marrow, they are known to exist in all tissues and organs, raising the question on whether they are identical cel...

journal_title：Stem cells and development

authors： Nora CC,Camassola M,Bellagamba B,Ikuta N,Christoff AP,Meirelles Lda S,Ayres R,Margis R,Nardi NB

更新日期：2012-07-01 00:00:00

abstract：:Nonpluripotent neural progenitor cells (NPCs) derived from the human fetal central nervous system were found to express a number of messenger RNA (mRNA) species associated with pluripotency, such as NANOG, REX1, and OCT4. The expression was restricted to small subpopulations of NPCs. In contrast to pluripotent stem ce...

journal_title：Stem cells and development

authors： Vincent PH,Benedikz E,Uhlén P,Hovatta O,Sundström E

更新日期：2017-06-15 00:00:00

abstract：:Red blood cell (RBC) differentiation from human induced pluripotent stem cells (hiPSCs) offers great potential for developmental studies and innovative therapies. However, ex vivo erythropoiesis from hiPSCs is currently limited by low efficiency and unphysiological conditions of common culture systems. Especially, the...

journal_title：Stem cells and development

authors： Bernecker C,Ackermann M,Lachmann N,Rohrhofer L,Zaehres H,Araúzo-Bravo MJ,van den Akker E,Schlenke P,Dorn I

更新日期：2019-12-01 00:00:00

abstract：:In a previous study we established colony assays suitable for studying murine adult (2-4 months) pancreatic progenitor cells plated in semisolid media containing methylcellulose and extracellular matrix proteins. Using these assays, we found robust in vitro progenitor cell activities (multilineage differentiation and ...

journal_title：Stem cells and development

authors： Jin L,Feng T,Zerda R,Chen CC,Riggs AD,Ku HT

更新日期：2014-04-15 00:00:00

abstract：:The mammalian inner ear is vulnerable to genetic disorders and aging, as well as to injuries caused by overstimulation, ototoxic drugs, and viral infections. Due to the poor regeneration of the sensory epithelium and the spiral ganglion neurons in the adult mammalian inner ear, cell replacement therapy strategies have...

journal_title：Stem cells and development

authors： Hu Z,Ulfendahl M

更新日期：2006-06-01 00:00:00

abstract：:Cell replacement therapy holds great promise for treating a wide range of human disorders. However, ensuring the predictable differentiation of transplanted stem cells, eliminating their risk of tumor formation, and generating fully functional cells after transplantation remain major challenges in regenerative medicin...

journal_title：Stem cells and development

authors： König N,Åkesson E,Telorack M,Vasylovska S,Ngamjariyawat A,Sundström E,Oster A,Trolle C,Berens C,Aldskogius H,Seiger Å,Kozlova EN

更新日期：2011-11-01 00:00:00

abstract：:The placenta is a transient organ that develops upon the initiation of pregnancy and is essential for embryonic development and fetal survival. The rodent placenta consists of distinct lineages and includes cell types that are analogous to those that make up the human placenta. Trophoblast cells within the labyrinth l...

journal_title：Stem cells and development

authors： Carey EA,Albers RE,Doliboa SR,Hughes M,Wyatt CN,Natale DR,Brown TL

更新日期：2014-12-01 00:00:00

abstract：:Allergic asthma is an inflammatory airway disease caused by T helper type 2 (Th2)-driven immune responses. Recent studies have demonstrated that adipose-derived stromal cells (ASC) have an immunosuppressive effect on T-cell activity. This study was performed to investigate whether ASC can inhibit Th2-dependent allergi...

journal_title：Stem cells and development

authors： Park HK,Cho KS,Park HY,Shin DH,Kim YK,Jung JS,Park SK,Roh HJ

更新日期：2010-11-01 00:00:00

abstract：:On May 6th 2014, the European Court of Human Rights added yet a new element to the judicial history of stem cells as it ruled in Durisotto v. Italy [appeal n. 62804/13]. The ruling rejected a patient claim to access an unproven cell therapy-an outcome that is certainly to be welcomed. However, this ruling is a missed ...

journal_title：Stem cells and development

authors： Rial-Sebbag E,Blasimme A

更新日期：2014-12-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00

abstract：:Collectively, lung diseases are one of the largest causes of premature death worldwide and represent a major focus in the field of regenerative medicine. Despite significant progress, only few stem cell platforms are currently available for cell-based therapy, disease modeling, and drug screening in the context of pul...

journal_title：Stem cells and development

authors： Hannan NR,Sampaziotis F,Segeritz CP,Hanley NA,Vallier L

更新日期：2015-07-15 00:00:00

abstract：:Oligodendrogenesis encompasses lineage specification of neural progenitor cells (NPCs) and differentiation into oligodendrocytes that ultimately culminates in the myelination of central nervous system axons. Each individual process must be tightly regulated by extracellular and cell-intrinsic mechanisms, whose identit...

journal_title：Stem cells and development

authors： Steffenhagen C,Dechant FX,Oberbauer E,Furtner T,Weidner N,Küry P,Aigner L,Rivera FJ

更新日期：2012-07-20 00:00:00

abstract：:Small-molecule inhibitors of glycogen synthase kinase 3β (GSK3β) have demonstrated strong anti-leukemia effects in preclinical studies. Here, we investigated the effect of GSK3β inhibitor 6-Bromoindirubin-3-oxime (BIO) previously shown to inhibit leukemia cell growth in vitro and of animal models on hematopoietic rege...

journal_title：Stem cells and development

authors： Shen S,Xu N,Klamer G,Ko KH,Khoo M,Ma D,Moore J,O'Brien TA,Dolnikov A

更新日期：2015-03-15 00:00:00

abstract：:Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. However, it is essential to unde...

journal_title：Stem cells and development

authors： Tatebayashi K,Tanaka Y,Nakano-Doi A,Sakuma R,Kamachi S,Shirakawa M,Uchida K,Kageyama H,Takagi T,Yoshimura S,Matsuyama T,Nakagomi T

更新日期：2017-06-01 00:00:00

abstract：:The success rate of human embryonic stem cell (hESC) derivation depends on both culture conditions and embryo quality and is routinely determined by morphological criteria. However, high incidence of chromosomal abnormality even in high-grade cleavage embryos from in vitro fertilization (IVF) patients suggests that th...

journal_title：Stem cells and development

authors： Ilic D,Caceres E,Lu S,Julian P,Foulk R,Krtolica A

更新日期：2010-01-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2) is a novel differentiation factor that is capable of inducing osteoblast differentiation and bone formation, making it an attractive option in treatment of bone defects, fractures, and spine fusions. Inflammation, which was a common situation during bone healing, is recognized to i...

journal_title：Stem cells and development

authors： Huang RL,Yuan Y,Zou GM,Liu G,Tu J,Li Q

更新日期：2014-02-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors suppress bone repair and bone formation by suppressing angiogenesis as well as potentially interfering with osteoblast and osteoclast functions. In spite of these reports, there is a controversy over the exact effects of COX-2 inhibitors on bone formation processes itself. This work...

journal_title：Stem cells and development

authors： Yoon DS,Yoo JH,Kim YH,Paik S,Han CD,Lee JW

更新日期：2010-10-01 00:00:00

abstract：:Induced pluripotent stem cell (iPSC) reprogramming requires sustained expression of multiple reprogramming factors for a limited period of time (10-30 days). Conventional iPSC reprogramming was achieved using lentiviral or simple retroviral vectors. Retroviral reprogramming has flaws of insertional mutagenesis, uncont...

journal_title：Stem cells and development

authors： Hu K

更新日期：2014-06-15 00:00:00

abstract：:The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...

journal_title：Stem cells and development

authors： Rüster B,Grace B,Seitz O,Seifried E,Henschler R

更新日期：2005-04-01 00:00:00

abstract：:In this study, we isolated and characterized spontaneously differentiated human embryonic stem cells (SD-hESCs) found in hESC colonies in comparison to the morphologically premature ESCs in the colonies to investigate the potential role of SD-hESCs in embryogenesis. SD-hESCs were distinguished from undifferentiated hE...

journal_title：Stem cells and development

authors： Lee JH,Hong KS,Mantel C,Broxmeyer HE,Lee MR,Kim KS

更新日期：2013-10-15 00:00:00

abstract：:In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. CD3(+) cells were separated by direct antibody-coupled magnetic beads, followed by DNA extraction according to a stan...

journal_title：Stem cells and development

authors： Uzunel M,Sairafi D,Remberger M,Mattsson J,Uhlin M

更新日期：2014-07-15 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) was used to analyze peripheral blood stem cells (PBSC) and stem cell assays (SCA) derived from them in 2 patients with acute myeloid leukemia (AML) with trisomy 8 as the sole chromosome abnormality prior to undergoing autologous stem cell transplantation. In both cases, the de...

journal_title：Stem cells and development

authors： Dodge W,Cruz J,Zamkoff K,Hurd D,Pettenati MJ

更新日期：2004-02-01 00:00:00

abstract：:Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy for repair of the diseased/injured central nervous system (CNS); however, controlling their differentiation remains a significant hurdle. This study is aimed at controlling differentiation and specifically at screening exogenous factors to...

journal_title：Stem cells and development

authors： Zahir T,Chen YF,MacDonald JF,Leipzig N,Tator CH,Shoichet MS

更新日期：2009-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The most potent ligand of the AhR known is 2,3,7,8-tetracholorodibenzo-p-dioxin. We previously reported tetrachlorodibenzo-p-dioxin-induced...

journal_title：Stem cells and development

authors： Singh KP,Garrett RW,Casado FL,Gasiewicz TA

更新日期：2011-05-01 00:00:00

abstract：:The field of regenerative medicine has increasingly recognized the importance to be inspired by developmental processes to identify signaling pathways crucial for 3D organogenesis and tissue regeneration. Here, we aimed at recapitulating the first events occurring during limb development (ie, cell condensation and exp...

journal_title：Stem cells and development

authors： Centola M,Tonnarelli B,Schären S,Glaser N,Barbero A,Martin I

更新日期：2013-11-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has multiple effects on proliferation and differentiation of human mesenchymal stem cells. Transforming growth factor-activated kinase-1 (TAK1) mediates the activation of nuclear factor-kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways in response to TNF-α. However, the r...

journal_title：Stem cells and development

authors： Lee SY,Lee JH,Shin KK,Kim DS,Kim YS,Bae YC,Jung JS

更新日期：2015-04-01 00:00:00

abstract：:Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells wer...

journal_title：Stem cells and development

authors： Park BW,Pan B,Toms D,Huynh E,Byun JH,Lee YM,Shen W,Rho GJ,Li J

更新日期：2014-07-15 00:00:00