T-cell receptor excision circle levels after allogeneic stem cell transplantation are predictive of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome.

abstract：:Improvement in angiogenesis using mesenchymal stem cells (MSCs) is evolving as an option in patients with vascular insufficiencies. The paracrine factors secreted by MSCs have been attributed to the angiogenic response. This study was conducted to identify the factors secreted by umbilical cord-derived MSCs (UCMSCs) t...

journal_title：Stem cells and development

authors： Kuchroo P,Dave V,Vijayan A,Viswanathan C,Ghosh D

更新日期：2015-02-15 00:00:00

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some SC types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess...

journal_title：Stem cells and development

authors： Di Trapani M,Bassi G,Ricciardi M,Fontana E,Bifari F,Pacelli L,Giacomello L,Pozzobon M,Féron F,De Coppi P,Anversa P,Fumagalli G,Decimo I,Menard C,Tarte K,Krampera M

更新日期：2013-11-15 00:00:00

abstract：:Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodo...

journal_title：Stem cells and development

authors： Tomokiyo A,Wada N,Maeda H

更新日期：2019-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors suppress bone repair and bone formation by suppressing angiogenesis as well as potentially interfering with osteoblast and osteoclast functions. In spite of these reports, there is a controversy over the exact effects of COX-2 inhibitors on bone formation processes itself. This work...

journal_title：Stem cells and development

authors： Yoon DS,Yoo JH,Kim YH,Paik S,Han CD,Lee JW

更新日期：2010-10-01 00:00:00

abstract：:Misexpression of the double homeodomain protein DUX4 in muscle is believed to cause facioscapulohumeral muscular dystrophy (FSHD). Although strategies are being devised to inhibit DUX4 activity in FSHD, there is little known about the normal function of this protein. Expression of DUX4 has been reported in pluripotent...

journal_title：Stem cells and development

authors： Dandapat A,Hartweck LM,Bosnakovski D,Kyba M

更新日期：2013-09-01 00:00:00

abstract：:Self-renewal and differentiation of endogenous stem cells (SCs) are essential for adult tissue homoeostasis and intrinsic healing capacity. In this study, we hypothesize that penis contains a small population of endogenous SCs, which might help rejuvenation of damaged erectile function. In this study, 60 newborn male ...

journal_title：Stem cells and development

authors： Xu Y,Guan R,Lei H,Gao Z,Li H,Hui Y,Zhou F,Wang L,Lin G,Xin Z

更新日期：2015-03-15 00:00:00

abstract：:Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors inf...

journal_title：Stem cells and development

authors： Aked J,Delavaran H,Lindvall O,Norrving B,Kokaia Z,Lindgren A

更新日期：2017-04-15 00:00:00

abstract：:Multipotent stem/progenitor cells from bone marrow stroma (mesenchymal stromal cells or MSCs) were previously shown to enhance proliferation and differentiation of neural stem cells (NSCs) in vivo, but the molecular basis of the effect was not defined. Here coculturing human MSCs (hMSCs) with rat NSCs (rNSCs) was foun...

journal_title：Stem cells and development

authors： Robinson AP,Foraker JE,Ylostalo J,Prockop DJ

更新日期：2011-02-01 00:00:00

abstract：:Since human mesenchymal stem cells (MSCs) are therapeutically attractive for tissue regeneration and repair, we examined the physiological responses of human umbilical cord blood-derived MSCs (hUCB-MSCs) to genotoxic stress. We found that that sublethal doses of reactive oxygen species (ROS) and ionizing radiation cau...

journal_title：Stem cells and development

authors： Ko E,Lee KY,Hwang DS

更新日期：2012-07-20 00:00:00

abstract：:Induced pluripotent stem cell (iPSC) reprogramming requires sustained expression of multiple reprogramming factors for a limited period of time (10-30 days). Conventional iPSC reprogramming was achieved using lentiviral or simple retroviral vectors. Retroviral reprogramming has flaws of insertional mutagenesis, uncont...

journal_title：Stem cells and development

authors： Hu K

更新日期：2014-06-15 00:00:00

abstract：:A comparative analysis of mouse and human pancreatic development may reveal common mechanisms that control key steps as organ morphogenesis and cell proliferation and differentiation. More specifically, understanding beta cell development remains an issue, despite recent progress related to their generation from human...

journal_title：Stem cells and development

authors： Bonfanti P,Nobecourt E,Oshima M,Albagli-Curiel O,Laurysens V,Stangé G,Sojoodi M,Heremans Y,Heimberg H,Scharfmann R

更新日期：2015-08-01 00:00:00

abstract：:The field of regenerative medicine has increasingly recognized the importance to be inspired by developmental processes to identify signaling pathways crucial for 3D organogenesis and tissue regeneration. Here, we aimed at recapitulating the first events occurring during limb development (ie, cell condensation and exp...

journal_title：Stem cells and development

authors： Centola M,Tonnarelli B,Schären S,Glaser N,Barbero A,Martin I

更新日期：2013-11-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. In this study, we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from random positioning machine (...

journal_title：Stem cells and development

authors： Ratushnyy A,Ezdakova M,Yakubets D,Buravkova L

更新日期：2018-06-15 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of multipotent mesenchymal stem cells with immunosuppressive capacities. However, the underlying mechanisms involved in the inhibitory effects of ADSCs on T cells are not completely elucidated. In this study, human peripheral blood mononuclear cells (PBMCs) stimulated with...

journal_title：Stem cells and development

authors： Zhou K,Guo S,Tong S,Sun Q,Li F,Zhang X,Qiao Y,Liang G

更新日期：2018-09-01 00:00:00

abstract：:PU.1 is a versatile hematopoietic cell-specific ETS-family transcriptional regulator required for the development of both the inborn and the adaptive immunity, owing to its potential ability to regulate the expression of multiple genes specific for different lineages during normal hematopoiesis. It functions in a cell...

journal_title：Stem cells and development

authors： Gangenahalli GU,Gupta P,Saluja D,Verma YK,Kishore V,Chandra R,Sharma RK,Ravindranath T

更新日期：2005-04-01 00:00:00

abstract：:The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...

journal_title：Stem cells and development

authors： Rüster B,Grace B,Seitz O,Seifried E,Henschler R

更新日期：2005-04-01 00:00:00

abstract：:Phenotypic guidance of embryonic stem (ES) cell fate is paramount if these cells are to be used for tissue repair and regeneration. Our objective was to compare two different cell culture feeders and their effect on proliferation, apoptosis, and differentiation of human (h) ES cells. HSF-6 hES cells were grown in Knoc...

journal_title：Stem cells and development

authors： Ozolek JA,Jane EP,Krowsoski L,Sammak PJ

更新日期：2007-06-01 00:00:00

abstract：:Balanced and precisely controlled processes between self-renewal and differentiation of hematopoietic stem cells (HSCs) into all blood lineages are critical for vertebrate definitive hematopoiesis. However, the molecular mechanisms underlying the maintenance and differentiation of HSCs have not been fully elucidated. ...

journal_title：Stem cells and development

authors： Hirabayashi R,Hozumi S,Higashijima S,Kikuchi Y

更新日期：2013-09-15 00:00:00

abstract：:Death ligands and their tumor necrosis factor receptor (TNFR) family receptors are the best-characterized and most efficient inducers of apoptotic signaling in somatic cells. In this study, we analyzed whether these prototypic activators of apoptosis are also expressed and able to be activated in human pluripotent ste...

journal_title：Stem cells and development

authors： Vinarsky V,Krivanek J,Rankel L,Nahacka Z,Barta T,Jaros J,Andera L,Hampl A

更新日期：2013-11-15 00:00:00

abstract：:Lymphedema is a medically irreversible condition for which currently conservative and surgical therapies are either ineffective or impractical. The potential use of progenitor and stem cell-based therapies has offered a paradigm that may provide alternative treatment options for lymphatic disorders. Moreover, basic re...

journal_title：Stem cells and development

authors： Qi S,Pan J

更新日期：2015-02-01 00:00:00

abstract：:Expression of the transcription factor Snail is required for normal vasculogenesis in the developing mouse embryo. In addition, tumors expressing Snail have been associated with a more malignant phenotype, with both increased invasive properties and angiogenesis. Although the relationship between Snail and vasculogene...

journal_title：Stem cells and development

authors： Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Murphy KM

更新日期：2012-01-20 00:00:00

abstract：:Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites o...

journal_title：Stem cells and development

authors： Hochheuser C,Windt LJ,Kunze NY,de Vos DL,Tytgat GAM,Voermans C,Timmerman I

更新日期：2021-01-15 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cel...

journal_title：Stem cells and development

authors： Barry FP,Murphy JM,English K,Mahon BP

更新日期：2005-06-01 00:00:00

abstract：:In the past few years research on stem cells has exploded as a tool to develop potential therapies to treat incurable neurodegenerative diseases. Stem cell transplantation has been effective in several animal models, but the underlying restorative mechanisms are still unknown. Several events such as cell fusion, neuro...

journal_title：Stem cells and development

authors： Cova L,Ratti A,Volta M,Fogh I,Cardin V,Corbo M,Silani V

更新日期：2004-02-01 00:00:00

abstract：:In the seminiferous epithelium of the testis, Sertoli cells are key niche cells directing proliferation and differentiation of spermatogonial stem cells (SSCs) into spermatozoa. Sertoli cells produce glial cell line-derived neurotrophic factor (GDNF), which is essential for SSC self-renewal and progenitor expansion. W...

journal_title：Stem cells and development

authors： Garcia TX,Parekh P,Gandhi P,Sinha K,Hofmann MC

更新日期：2017-04-15 00:00:00

abstract：:Hematopoietic stem cells (HSCs) possess a distinct ability to perpetuate through self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. A better understanding of the molecular mechanisms by which HSCs replicate and differentiate from the perspective of developing ne...

journal_title：Stem cells and development

authors： Sharma S,Gurudutta GU,Satija NK,Pati S,Afrin F,Gupta P,Verma YK,Singh VK,Tripathi RP

更新日期：2006-12-01 00:00:00

abstract：:Differential staining is an immunocytochemical staining that visualizes trophectoderm (TE) and the inner cell mass (ICM) of the blastocysts. It is used to determine the blastocyst quality, but could also be a useful tool to assess the integration site of injected cells into the early embryo. This is relevant for testi...

journal_title：Stem cells and development

authors： Secher JO,Freude KK,Li R,Callesen H

更新日期：2015-05-01 00:00:00

abstract：:Although amniotic fluid cells can differentiate into several mesenchymal lineages and have been proposed as a valuable therapeutic cell source, their ability to undergo terminal neuronal differentiation remains a cause of controversy. The aim of this study was to investigate the neuronal differentiation ability of the...

journal_title：Stem cells and development

authors： Prasongchean W,Bagni M,Calzarossa C,De Coppi P,Ferretti P

更新日期：2012-03-20 00:00:00