The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells.

abstract：:A murine stromal cell line (OP9-DL1) expressing a notch ligand, Delta-like-1, has been shown to be able to drive the differentiation of both murine and human hematopoietic progenitors into T cells in vitro. Further studies showed that hematopoietic progenitors transduced by a retroviral vector to express a human CD8 T...

journal_title：Stem cells and development

authors： Dai B,Wang P

更新日期：2009-03-01 00:00:00

abstract：:Bone marrow human mesenchymal stem cells (hMSCs) are known to survive in serum-free media, when most normal somatic cells do not survive. We found that the endogenously-activated bone morphogenetic protein (BMP) pathway is involved in this cellular behavior. Under this culture condition, phosphorylated Smad1 (PSmad1),...

journal_title：Stem cells and development

authors： Solmesky LJ,Abekasis M,Bulvik S,Weil M

更新日期：2009-11-01 00:00:00

abstract：:Cell mobilization, a process that influences circulation, margination, and finally, homing play key roles in the regeneration processes mediated by stem cells. Recent studies as well as prior studies from our group indicate an important role of the spleen in hematopoietic reconstitution, but to date the role of the sp...

journal_title：Stem cells and development

authors： Filip S,Mokrý J,Vávrová J,Cížková D,Sinkorová Z,Mičuda S,Bláha M,English D

更新日期：2012-03-20 00:00:00

abstract：:Pluripotent human embryonic stem cells (hESCs) provide appropriate systems for developmental studies and prospective donor cell sources for regenerative medicine. Identification of surface markers specific to hESCs is a prerequisite for studying hESC biology and can be used to generate clinical-level donor cell prepar...

journal_title：Stem cells and development

authors： Choi HS,Kim WT,Kim H,Kim JJ,Ko JY,Lee SW,Jang YJ,Kim SJ,Lee MJ,Jung HS,Kzhyshkowska J,Um SJ,Lee MY,Lee SH,Kim CH,Ryu CJ

更新日期：2011-04-01 00:00:00

abstract：:Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites o...

journal_title：Stem cells and development

authors： Hochheuser C,Windt LJ,Kunze NY,de Vos DL,Tytgat GAM,Voermans C,Timmerman I

更新日期：2021-01-15 00:00:00

abstract：:Although the pluripotent and proliferative capacity of embryonic germ (EG) cells is thought to be equivalent to that of embryonic stem (ES) cells, there has been far less attention focused on the potential use of EG cells for applications in developing novel strategies of tissue transplantation in the treatment of deg...

journal_title：Stem cells and development

authors： Wu Y,Ge C,Zeng W,Zhang C

更新日期：2010-02-01 00:00:00

abstract：:There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hype...

journal_title：Stem cells and development

authors： Aliotta JM,Keaney PJ,Warburton RR,DelTatto M,Dooner MS,Passero MA,Quesenberry PJ,Klinger JR

更新日期：2009-06-01 00:00:00

abstract：:Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demo...

journal_title：Stem cells and development

authors： Christensen C,Zhang S,Roelink H

更新日期：2006-10-01 00:00:00

abstract：:While transplantation of human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) shows therapeutic potential in animal stroke models, major concerns for translating hiPSC therapy to the clinic are efficacy and safety. Therefore, there is a demand to develop an optimal strategy to enhance the engraft...

journal_title：Stem cells and development

authors： Ould-Brahim F,Sarma SN,Syal C,Lu KJ,Seegobin M,Carter A,Jeffers MS,Doré C,Stanford WL,Corbett D,Wang J

更新日期：2018-08-15 00:00:00

abstract：:Ossification of the posterior longitudinal ligament (OPLL) is characterized by ectopic OPLL. To date, the specific molecular pathogenesis of OPLL has not been clearly elucidated. In this study, bone marrow-derived mesenchymal stem cells obtained from healthy donors (HD-MSCs) and patients with OPLL (OPLL-MSCs) were cul...

journal_title：Stem cells and development

authors： Cai Z,Wu B,Ye G,Liu W,Chen K,Wang P,Xie Z,Li J,Zheng G,Yu W,Su Z,Lin J,Wu Y,Shen H

更新日期：2020-12-01 00:00:00

abstract：:On May 6th 2014, the European Court of Human Rights added yet a new element to the judicial history of stem cells as it ruled in Durisotto v. Italy [appeal n. 62804/13]. The ruling rejected a patient claim to access an unproven cell therapy-an outcome that is certainly to be welcomed. However, this ruling is a missed ...

journal_title：Stem cells and development

authors： Rial-Sebbag E,Blasimme A

更新日期：2014-12-01 00:00:00

abstract：:The enhanced proliferation of mesenchymal stem cells (MSCs) can be helpful for the clinical translation of cell therapy. Low-level laser irradiation (LLLI) has been demonstrated as regulating MSC proliferation. MicroRNAs (miRNAs) are involved in various pathophysiologic processes in stem cells, but the role of miRNAs ...

journal_title：Stem cells and development

authors： Wang J,Huang W,Wu Y,Hou J,Nie Y,Gu H,Li J,Hu S,Zhang H

更新日期：2012-09-01 00:00:00

abstract：:Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently,...

journal_title：Stem cells and development

authors： Marfia G,Navone SE,Hadi LA,Paroni M,Berno V,Beretta M,Gualtierotti R,Ingegnoli F,Levi V,Miozzo M,Geginat J,Fassina L,Rampini P,Tremolada C,Riboni L,Campanella R

更新日期：2016-07-15 00:00:00

abstract：:Many of the currently established human embryonic stem (hES) cell lines have been characterized extensively in terms of their gene expression profiles and genetic stability in culture. Recent studies have indicated that microRNAs (miRNAs), a class of noncoding small RNAs that participate in the regulation of gene expr...

journal_title：Stem cells and development

authors： Lakshmipathy U,Love B,Goff LA,Jörnsten R,Graichen R,Hart RP,Chesnut JD

更新日期：2007-12-01 00:00:00

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we analyzed in this randomized, controlled study the influence of intracoronary autologous freshly isolated bone marrow cell...

journal_title：Stem cells and development

authors： Turan RG,Bozdag-Turan I,Ortak J,Akin I,Kische S,Schneider H,Turan CH,Rehders TC,Rauchhaus M,Kleinfeldt T,Adolph E,Brehm M,Yokus S,Steiner S,Sahin K,Nienaber CA,Ince H

更新日期：2011-09-01 00:00:00

abstract：:The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. Th...

journal_title：Stem cells and development

authors： Xie Y,Awonuga A,Liu J,Rings E,Puscheck EE,Rappolee DA

更新日期：2013-05-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities that enhances the efficacy of TRAIL in glioma is much sought after. In ...

journal_title：Stem cells and development

authors： Yulyana Y,Endaya BB,Ng WH,Guo CM,Hui KM,Lam PY,Ho IA

更新日期：2013-07-01 00:00:00

abstract：:Multipotent stem/progenitor cells from bone marrow stroma (mesenchymal stromal cells or MSCs) were previously shown to enhance proliferation and differentiation of neural stem cells (NSCs) in vivo, but the molecular basis of the effect was not defined. Here coculturing human MSCs (hMSCs) with rat NSCs (rNSCs) was foun...

journal_title：Stem cells and development

authors： Robinson AP,Foraker JE,Ylostalo J,Prockop DJ

更新日期：2011-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. In this study, we sh...

journal_title：Stem cells and development

authors： Liu X,Ren S,Ge C,Cheng K,Li X,Zhao RC

更新日期：2018-04-15 00:00:00

abstract：:Phenotypic guidance of embryonic stem (ES) cell fate is paramount if these cells are to be used for tissue repair and regeneration. Our objective was to compare two different cell culture feeders and their effect on proliferation, apoptosis, and differentiation of human (h) ES cells. HSF-6 hES cells were grown in Knoc...

journal_title：Stem cells and development

authors： Ozolek JA,Jane EP,Krowsoski L,Sammak PJ

更新日期：2007-06-01 00:00:00

abstract：:To better understand the basis of variation in cellular reprogramming, we performed experiments with two primary objectives: first, to determine the degree of difference, if any, in reprogramming efficiency among cells lines of a similar type after accounting for technical variables, and second, to compare the efficie...

journal_title：Stem cells and development

authors： Alicea B,Murthy S,Keaton SA,Cobbett P,Cibelli JB,Suhr ST

更新日期：2013-10-01 00:00:00

abstract：:My concept of cell differentiation involves genetic information from DNA being transcribed into mRNA proteins-morphogenes (mRNAs+ homeodomain proteins)-and stored in the ovoplasm as maternal inheritance, or cytoplasmic genetic memory. Feedback mechanism(s) allow these morphogenes to selectively unlock new genes, regul...

journal_title：Stem cells and development

authors： Kristeva MA

更新日期：2008-10-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to a cascade of secondary chemical insults, including oxidative stress and glutamate excitotoxicity, which damage host neurons and glia. Transplantation of exogenous neural stem/progenitor cells (NSPCs) has shown promise in enhancing regeneration after SCI, although survival of...

journal_title：Stem cells and development

authors： Hachem LD,Mothe AJ,Tator CH

更新日期：2016-08-15 00:00:00

abstract：:We have previously isolated mesenchymal stromal cells (MSCs) from the tracheal aspirates of premature neonates with respiratory distress. Although isolation of MSCs correlates with the development of bronchopulmonary dysplasia, the physiologic role of these cells remains unclear. To address this, we further characteri...

journal_title：Stem cells and development

authors： Bozyk PD,Popova AP,Bentley JK,Goldsmith AM,Linn MJ,Weiss DJ,Hershenson MB

更新日期：2011-11-01 00:00:00

abstract：:PU.1 is a versatile hematopoietic cell-specific ETS-family transcriptional regulator required for the development of both the inborn and the adaptive immunity, owing to its potential ability to regulate the expression of multiple genes specific for different lineages during normal hematopoiesis. It functions in a cell...

journal_title：Stem cells and development

authors： Gangenahalli GU,Gupta P,Saluja D,Verma YK,Kishore V,Chandra R,Sharma RK,Ravindranath T

更新日期：2005-04-01 00:00:00

abstract：:Stem cell factor (SCF) stimulation of the receptor tyrosine kinase c-kit has effects on the proliferation, differentiation, and apoptotic regulation of hematopoietic progenitor cell populations. Rat bone marrow myelomonocytic stem cells (MSC) isolated in vitro by wheat germ agglutinin culture exclusively undergo self-...

journal_title：Stem cells and development

authors： Lucas T,Pratscher B,Fink D,Wolschek M,Samorapoompichit P,Schöfer C,Pehamberger H,Müller M,Sorensen P,Jansen B

更新日期：2005-10-01 00:00:00

abstract：:Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe adverse reaction, which results in progressive bone destruction in the maxillofacial region of patients. To date, the pathological mechanisms remain largely unclear. Recently, we found that BRONJ patient had significantly deep periodontal pockets and...

journal_title：Stem cells and development

authors： Li M,Yu Y,Shi Y,Zhou Y,Zhang W,Hua H,Ge J,Zhang Z,Ye D,Yang C,Wang S

更新日期：2020-02-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are more and more frequently used to treat orthopedic injuries in horses. However, these cells are limited in their expandability and differentiation capacity. Recently, the first equine-induced pluripotent stem cell (iPSC) lines were reported by us [ 1 ]. In vitro differen...

journal_title：Stem cells and development

authors： Lepage SI,Nagy K,Sung HK,Kandel RA,Nagy A,Koch TG

更新日期：2016-01-01 00:00:00

abstract：:A long-term goal of mesenchymal progenitor cell (MPC) research is to identify cell-surface markers to facilitate MPC isolation. One reported MPC feature in humans and other species is lack of CD14 (lipopolysaccharide receptor) expression. The aim of this study was to evaluate CD14 as an MPC sorting marker. Our hypothe...

journal_title：Stem cells and development

authors： Hackett CH,Flaminio MJ,Fortier LA

更新日期：2011-04-01 00:00:00