Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway.

abstract：:The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. Th...

journal_title：Stem cells and development

authors： Xie Y,Awonuga A,Liu J,Rings E,Puscheck EE,Rappolee DA

更新日期：2013-05-15 00:00:00

abstract：:Betacellulin (BTC), a ligand of the epidermal growth factor receptor, has been shown to promote growth and differentiation of pancreatic β-cells and to improve glucose metabolism in experimental diabetic rodent models. Mesenchymal stem cells (MSCs) have been already proved to be multipotent. Recent work has attributed...

journal_title：Stem cells and development

authors： Paz AH,Salton GD,Ayala-Lugo A,Gomes C,Terraciano P,Scalco R,Laurino CC,Passos EP,Schneider MR,Meurer L,Cirne-Lima E

更新日期：2011-02-01 00:00:00

abstract：:Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in different clinical presentations, with variable penetrance, are unknown. To better understand the m...

journal_title：Stem cells and development

authors： De Los Angeles A,Tunbridge EM

更新日期：2020-09-01 00:00:00

abstract：:With an incidence of ∼1:3,500 to 5,000 in male children, Duchenne muscular dystrophy (DMD) is an X-linked disorder in which progressive muscle degeneration occurs and affected boys usually die in their twenties or thirties. Cardiac involvement occurs in 90% of patients and heart failure accounts for up to 40% of death...

journal_title：Stem cells and development

authors： Dick E,Kalra S,Anderson D,George V,Ritso M,Laval SH,Barresi R,Aartsma-Rus A,Lochmüller H,Denning C

更新日期：2013-10-15 00:00:00

abstract：:The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration ...

journal_title：Stem cells and development

authors： Cousins FL,O DF,Ong YR,Breault DT,Deane JA,Gargett CE

更新日期：2019-01-01 00:00:00

abstract：:Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...

journal_title：Stem cells and development

authors： Wu JH,Wang HJ,Tan YZ,Li ZH

更新日期：2012-05-20 00:00:00

abstract：:Expression of the transcription factor Snail is required for normal vasculogenesis in the developing mouse embryo. In addition, tumors expressing Snail have been associated with a more malignant phenotype, with both increased invasive properties and angiogenesis. Although the relationship between Snail and vasculogene...

journal_title：Stem cells and development

authors： Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Murphy KM

更新日期：2012-01-20 00:00:00

abstract：:In the mammalian olfactory epithelium (OE), olfactory receptor neurons (ORNs) are continuously regenerated throughout the animal's lifetime. Horizontal basal cells (HBCs) in the OE express the epithelial marker keratin 5 (K5) and the stem cell marker Pax6 and are considered relatively quiescent tissue stem cells in th...

journal_title：Stem cells and development

authors： Suzuki J,Sakurai K,Yamazaki M,Abe M,Inada H,Sakimura K,Katori Y,Osumi N

更新日期：2015-08-15 00:00:00

abstract：:We have isolated a novel progenitor cell population from adult rat pancreatic ducts, termed pancreatic-derived progenitor cells (PDPCs). Here, we report the in vitro culture, selection, and characterization of Thy1.1-positive and Thy1.1-negative PDPC subpopulations. These cells exhibit bipotentiality for differentiati...

journal_title：Stem cells and development

authors： Stevenson KS,McGlynn L,Hodge M,McLinden H,George WD,Davies RW,Shiels PG

更新日期：2009-12-01 00:00:00

abstract：:With the recent advances in regenerative medicine, nanotechnology has created a niche for itself as a promising avenue in this field. Innumerable studies have been carried out by researchers using virus-based methodologies for the purpose of epigenetic reprogramming. Although this method is ostensibly safe, nonetheles...

journal_title：Stem cells and development

authors： Kadengodlu PA,Rai VR

更新日期：2015-03-01 00:00:00

abstract：:Ex vivo cultures of human bone marrow-derived mesenchymal stem cells (MSCs) contain subsets of progenitors exhibiting dissimilar properties. One of these subsets comprises uncommitted progenitors displaying distinctive features, such as morphology, a quiescent condition, growth factor production, and restricted tissue...

journal_title：Stem cells and development

authors： Minguell JJ,Fierro FA,Epuñan MJ,Erices AA,Sierralta WD

更新日期：2005-08-01 00:00:00

abstract：:True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology of tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable tendon cell and tissue differentiation based on a...

journal_title：Stem cells and development

authors： Noack S,Seiffart V,Willbold E,Laggies S,Winkel A,Shahab-Osterloh S,Flörkemeier T,Hertwig F,Steinhoff C,Nuber UA,Gross G,Hoffmann A

更新日期：2014-08-15 00:00:00

abstract：:How hematopoietic stem cells (HSCs) maintain the balance of self-renewal and differentiation could be partially ascribed to asymmetric and symmetric division patterns. However, a simple and effective method to detect stem cell division patterns is lacking. In this study, we introduce a strategy to describe stem cells ...

journal_title：Stem cells and development

authors： Yang WZ,Yu WY,Chen T,Wang XF,Dong F,Xie ME,Gong YM,Liang HY,Fu WC

更新日期：2019-07-15 00:00:00

abstract：:Special features of mesenchymal stem cells (MSCs) have made them a popular tool in cell therapy and tissue engineering. Although mouse animal models and murine MSCs are common tools in this field, our understanding of the effect of in vitro expansion on the behavior of these cells is poor and controversial. In additio...

journal_title：Stem cells and development

authors： Ahmadbeigi N,Soleimani M,Gheisari Y,Vasei M,Amanpour S,Bagherizadeh I,Shariati SA,Azadmanesh K,Amini S,Shafiee A,Arabkari V,Nardi NB

更新日期：2011-08-01 00:00:00

abstract：:Cell-based gene therapy holds a great promise for the treatment of human malignancy. Among different cells, mesenchymal stem cells (MSCs) are emerging as valuable anti-cancer agents that have the potential to be used to treat a number of different cancer types. They have inherent migratory properties, which allow them...

journal_title：Stem cells and development

authors： Nowakowski A,Drela K,Rozycka J,Janowski M,Lukomska B

更新日期：2016-10-01 00:00:00

abstract：:Umbilical cord blood (CB) CD34(+) cells, on the basis of flow cytometry analysis, are comprised of multiple populations. In in vitro assays, only CD34(regular) FSC(high) cells are functional and low percentages of nonfunctional CD34(regular) FSC(low) cells were determined to be present in liquid-stored CB. Liquid-stor...

journal_title：Stem cells and development

authors： Greco NJ,Seetharaman S,Kurtz J,Lee WR,Moroff G

更新日期：2006-02-01 00:00:00

abstract：:Accumulating evidence suggests that the delivery of human adipose tissue-derived stromal cells (hASCs) has great potential as regenerative therapy. This was performed to develop a method for expanding hASCs by reducing the amount of serum required. We demonstrate that hASCs were able to expand efficiently in media con...

journal_title：Stem cells and development

authors： Iwashima S,Ozaki T,Maruyama S,Saka Y,Kobori M,Omae K,Yamaguchi H,Niimi T,Toriyama K,Kamei Y,Torii S,Murohara T,Yuzawa Y,Kitagawa Y,Matsuo S

更新日期：2009-05-01 00:00:00

abstract：:Recent studies have focused on transcriptional regulation and gene expression profiling of human embryonic stem cells (hESCs). However, little information is available regarding the relationship between RNA expression and transcriptional regulation, which is critical in the complete understanding of pluripotency and d...

journal_title：Stem cells and development

authors： Player A,Wang Y,Bhattacharya B,Rao M,Puri RK,Kawasaki ES

更新日期：2006-06-01 00:00:00

abstract：:The increasing use of mesenchymal stromal cells (MSC) in clinical cellular therapy requires a safe and controlled production process compliant with Good Manufacturing Practice guidelines. Pooled blood group AB human serum (HS) has been used to replace fetal bovine serum (FBS), critically rated by the regulatory agenci...

journal_title：Stem cells and development

authors： Dreher L,Elvers-Hornung S,Brinkmann I,Huck V,Henschler R,Gloe T,Klüter H,Bieback K

更新日期：2013-03-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:Cell therapy with adult mesenchymal stem cells (MSCs) is a promising approach to regenerative medicine and autoimmune diseases. There are various approaches to improve the efficacy of MSC-based therapeutics, and MSC preparation as spheroidal aggregates, or MSC spheroids, is a novel preparatory and delivery method. Sph...

journal_title：Stem cells and development

authors： Cesarz Z,Funnell JL,Guan J,Tamama K

更新日期：2016-04-15 00:00:00

abstract：:Müller glia are responsible for the retina regeneration observed in zebrafish. Although the human retina harbors Müller glia with stem cell characteristics, there is no evidence that they regenerate the retina after disease or injury. Transforming growth factor-β (TGFβ) and Wnt signaling regulate retinal neurogenesis ...

journal_title：Stem cells and development

authors： Angbohang A,Wu N,Charalambous T,Eastlake K,Lei Y,Kim YS,Sun XH,Limb GA

更新日期：2016-01-01 00:00:00

abstract：:Adipose tissue (AT) is composed of mature adipocytes and stromal vascular fraction (SVF) cells, including adipose stem/stromal cells (ASCs). We characterized hematopoietic cells residing in human nonobese AT by analyzing the SVF isolated from human lipoaspirates and peripheral blood (PB). Flow cytometry revealed that ...

journal_title：Stem cells and development

authors： Eto H,Ishimine H,Kinoshita K,Watanabe-Susaki K,Kato H,Doi K,Kuno S,Kurisaki A,Yoshimura K

更新日期：2013-03-15 00:00:00

abstract：:Extraembryonic endoderm (XEN) cells are stem cell lines derived from primitive endoderm cells of inner cell mass in blastocysts. These cells have self-renewal properties and differentiate into visceral endoderm (VE) and parietal endoderm (PE) of the yolk sac. Recently, it has been reported that XEN cells can contribut...

journal_title：Stem cells and development

authors： Nishimura T,Unezaki N,Kanegi R,Wijesekera DPH,Hatoya S,Sugiura K,Kawate N,Tamada H,Imai H,Inaba T

更新日期：2017-08-01 00:00:00

abstract：:Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors inf...

journal_title：Stem cells and development

authors： Aked J,Delavaran H,Lindvall O,Norrving B,Kokaia Z,Lindgren A

更新日期：2017-04-15 00:00:00

abstract：:Most disease-modifying therapeutic approaches in Alzheimer's disease (AD) aim to reduce the accumulation of neurotoxic amyloid-beta (Abeta) peptides as a hallmark of AD pathogenesis. Here we report the in vitro basis for a potential autologous stem cell-based strategy for widespread delivery of enzymatic activities ag...

journal_title：Stem cells and development

authors： Habisch HJ,Schmid B,von Arnim CA,Ludolph AC,Brenner R,Storch A

更新日期：2010-05-01 00:00:00

abstract：:Dental follicle stem cells (DFSCs), which are the stem cells present in the dental follicle tissue of the tooth germ and are derived from the neural crest, are direct precursor cells of periodontal tissues and can form the periodontal ligament, cementum, and alveolar bone proper in the late stage of tooth development....

journal_title：Stem cells and development

authors： Zhang J,Ding H,Liu X,Sheng Y,Liu X,Jiang C

更新日期：2019-08-01 00:00:00

abstract：:In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and their effects in a peripheral nerve injury model were determined. In vitro growth factor stimulation of the cells resulted in increased s...

journal_title：Stem cells and development

authors： Kingham PJ,Kolar MK,Novikova LN,Novikov LN,Wiberg M

更新日期：2014-04-01 00:00:00

abstract：:Osteophytes are a distinct feature of osteoarthritis (OA). Their formation may be related to pluripotential cells in the periosteum responding to stimulus during OA. This study aimed to isolate stem cells from osteophyte tissues and to characterize their phenotype, proliferation, and differentiation potential, as well...

journal_title：Stem cells and development

authors： Singh S,Jones BJ,Crawford R,Xiao Y

更新日期：2008-04-01 00:00:00

abstract：:In this work, we evaluated the expansion of human hematopoietic stem cells from umbilical cord blood in roller bottles. The Iscove's modified Dulbecco's medium, the Stem Pro 34-SFM medium, and the L-15 Leibovitz's medium for cultures in CO(2)-free atmosphere were assessed. At day 5 of culture, total colony forming uni...

journal_title：Stem cells and development

authors： Andrade-Zaldívar H,Kalixto-Sánchez MA,de la Rosa AP,De León-Rodríguez A

更新日期：2011-04-01 00:00:00