Soft Elasticity-Associated Signaling and Bone Morphogenic Protein 2 Are Key Regulators of Mesenchymal Stem Cell Spheroidal Aggregates.

abstract：:Multipotent bone marrow-derived mesenchymal stem/stromal cells (BMSCs) exhibit a finite life span after ex vivo expansion leading to cellular senescence. Many factors can contribute to this. Recently, our group has identified for the first time expression of the chemokine-like factor superfamily 8 (CMTM8) gene in cult...

journal_title：Stem cells and development

authors： H'ng CH,Camp E,Anderson PJ,Zannettino ACW,Gronthos S

更新日期：2020-07-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are somatic cells that have been reprogrammed to a pluripotent state via introduction of defined transcription factors. iPSCs are a valuable resource for regenerative medicine, but whether iPSCs are identical to embryonic stem cells (ESCs) remains unclear. In this study, we perfo...

journal_title：Stem cells and development

authors： Kim SY,Kim MJ,Jung H,Kim WK,Kwon SO,Son MJ,Jang IS,Choi JS,Park SG,Park BC,Han YM,Lee SC,Cho YS,Bae KH

更新日期：2012-05-20 00:00:00

abstract：:Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently,...

journal_title：Stem cells and development

authors： Marfia G,Navone SE,Hadi LA,Paroni M,Berno V,Beretta M,Gualtierotti R,Ingegnoli F,Levi V,Miozzo M,Geginat J,Fassina L,Rampini P,Tremolada C,Riboni L,Campanella R

更新日期：2016-07-15 00:00:00

abstract：:Members of helix-loop-helix (HLH) protein family of Id (inhibitor of differentiation) dimerize with bHLH transcription factors and function as negative regulators of differentiation during development. Most of inhibitory roles of Id proteins have been demonstrated in non-neural tissues, and their roles in the developi...

journal_title：Stem cells and development

authors： Jung S,Park RH,Kim S,Jeon YJ,Ham DS,Jung MY,Kim SS,Lee YD,Park CH,Suh-Kim H

更新日期：2010-06-01 00:00:00

abstract：:Spiral ganglion neurons (SGNs) are usually damaged in sensorineural hearing loss. SGN-derived neural stem cells (NSCs) have been identified and proposed to differentiate into neurons to replace damaged SGNs. However, it remains obscure whether SGN-NSC-derived neurons (ScNs) are electrophysiologically functional and po...

journal_title：Stem cells and development

authors： Li X,Aleardi A,Wang J,Zhou Y,Andrade R,Hu Z

更新日期：2016-05-15 00:00:00

abstract：:In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and their effects in a peripheral nerve injury model were determined. In vitro growth factor stimulation of the cells resulted in increased s...

journal_title：Stem cells and development

authors： Kingham PJ,Kolar MK,Novikova LN,Novikov LN,Wiberg M

更新日期：2014-04-01 00:00:00

abstract：:Human embryonic stem (hES) cells represent a potentially unlimited source of transplantable beta-cells for the treatment of diabetes. Here we describe a differentiation strategy that reproducibly directs HES3, an National Institutes of Health (NIH)-registered hES cell line, into cells of the pancreatic endocrine linea...

journal_title：Stem cells and development

authors： Phillips BW,Hentze H,Rust WL,Chen QP,Chipperfield H,Tan EK,Abraham S,Sadasivam A,Soong PL,Wang ST,Lim R,Sun W,Colman A,Dunn NR

更新日期：2007-08-01 00:00:00

abstract：:Intermediate progenitor populations play a crucial role in the regional specification and differentiation of the cranial neural crest. On the basis of global gene expression profiles, gene cohort expression levels, and epigenetic modifications, we have defined key factors involved in the differentiation of dental foll...

journal_title：Stem cells and development

authors： Dangaria SJ,Ito Y,Luan X,Diekwisch TG

更新日期：2011-01-01 00:00:00

abstract：:Pluripotent stem cell-derived endothelial cells (ECs) have great potential to be used in vascular therapy or tissue engineering. It is also much desired to obtain arterial or venous ECs for specific applications. Factors that are critical for the proper arterial or venous differentiation from pluripotent stem cells st...

journal_title：Stem cells and development

authors： Kim D,Lee V,Dorsey TB,Niklason LE,Gui L,Dai G

更新日期：2018-04-01 00:00:00

abstract：:Special features of mesenchymal stem cells (MSCs) have made them a popular tool in cell therapy and tissue engineering. Although mouse animal models and murine MSCs are common tools in this field, our understanding of the effect of in vitro expansion on the behavior of these cells is poor and controversial. In additio...

journal_title：Stem cells and development

authors： Ahmadbeigi N,Soleimani M,Gheisari Y,Vasei M,Amanpour S,Bagherizadeh I,Shariati SA,Azadmanesh K,Amini S,Shafiee A,Arabkari V,Nardi NB

更新日期：2011-08-01 00:00:00

abstract：:Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is an extracellular matrix...

journal_title：Stem cells and development

authors： Ghazalli N,Mahdavi A,Feng T,Jin L,Kozlowski MT,Hsu J,Riggs AD,Tirrell DA,Ku HT

更新日期：2015-09-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00

abstract：:Extraembryonic endoderm (XEN) cells are stem cell lines derived from primitive endoderm cells of inner cell mass in blastocysts. These cells have self-renewal properties and differentiate into visceral endoderm (VE) and parietal endoderm (PE) of the yolk sac. Recently, it has been reported that XEN cells can contribut...

journal_title：Stem cells and development

authors： Nishimura T,Unezaki N,Kanegi R,Wijesekera DPH,Hatoya S,Sugiura K,Kawate N,Tamada H,Imai H,Inaba T

更新日期：2017-08-01 00:00:00

abstract：:Body axes and germ layers evolve at gastrulation, and in mammals are driven by many genes; however, what orchestrates the genetic pathways during gastrulation remains elusive. Previously, we presented evidence that microRNA-17 (miRNA-17) family members, miR-17-5p, miR-20a, miR-93, and miR-106a were differentially expr...

journal_title：Stem cells and development

authors： Larabee SM,Coia H,Jones S,Cheung E,Gallicano GI

更新日期：2015-02-01 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) was used to analyze peripheral blood stem cells (PBSC) and stem cell assays (SCA) derived from them in 2 patients with acute myeloid leukemia (AML) with trisomy 8 as the sole chromosome abnormality prior to undergoing autologous stem cell transplantation. In both cases, the de...

journal_title：Stem cells and development

authors： Dodge W,Cruz J,Zamkoff K,Hurd D,Pettenati MJ

更新日期：2004-02-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Umbilical cord blood (CB) CD34(+) cells, on the basis of flow cytometry analysis, are comprised of multiple populations. In in vitro assays, only CD34(regular) FSC(high) cells are functional and low percentages of nonfunctional CD34(regular) FSC(low) cells were determined to be present in liquid-stored CB. Liquid-stor...

journal_title：Stem cells and development

authors： Greco NJ,Seetharaman S,Kurtz J,Lee WR,Moroff G

更新日期：2006-02-01 00:00:00

abstract：:We recently reported the isolation and characterization of a population of pancreatic progenitor cells (PPCs) from early trimester human fetal pancreata. The PPCs, being the forerunners of adult pancreatic cell lineages, were amenable to growth and differentiation into insulin-secreting islet-like cell clusters (ICCs)...

journal_title：Stem cells and development

authors： Leung KK,Suen PM,Lau TK,Ko WH,Yao KM,Leung PS

更新日期：2009-09-01 00:00:00

abstract：:Small-molecule inhibitors of glycogen synthase kinase 3β (GSK3β) have demonstrated strong anti-leukemia effects in preclinical studies. Here, we investigated the effect of GSK3β inhibitor 6-Bromoindirubin-3-oxime (BIO) previously shown to inhibit leukemia cell growth in vitro and of animal models on hematopoietic rege...

journal_title：Stem cells and development

authors： Shen S,Xu N,Klamer G,Ko KH,Khoo M,Ma D,Moore J,O'Brien TA,Dolnikov A

更新日期：2015-03-15 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) show great potential for clinical and experimental use due to their capacity to self-renew and differentiate into multiple mesenchymal lineages. However, disadvantages of primary cultures of hMSCs are the limited in vitro lifespan, and the variable properties of cells from diffe...

journal_title：Stem cells and development

authors： Skårn M,Noordhuis P,Wang MY,Veuger M,Kresse SH,Egeland EV,Micci F,Namløs HM,Håkelien AM,Olafsrud SM,Lorenz S,Haraldsen G,Kvalheim G,Meza-Zepeda LA,Myklebost O

更新日期：2014-10-01 00:00:00

abstract：:P311 is a newly discovered functional gene, and it has been proved to play a key role in blood pressure homeostasis, glioblastoma invasion, renal fibrosis, hypertrophic scar formation, and others. In this study, for the first time, we found that P311 could enhance reepithelialization during wound healing via promoting...

journal_title：Stem cells and development

authors： Yao Z,Li H,He W,Yang S,Zhang X,Zhan R,Xu R,Tan J,Zhou J,Wu J,Luo G

更新日期：2017-03-15 00:00:00

abstract：:Studies on rodent bone marrow stromal cells (MSCs) have revealed a capacity, for at least a portion of cells, to express neuron-like traits after differentiation in culture. Little, however, is known about the ability of human MSCs in this regard. We show here that incubation with certain differentiation cocktails, pa...

journal_title：Stem cells and development

authors： Suon S,Jin H,Donaldson AE,Caterson EJ,Tuan RS,Deschennes G,Marshall C,Iacovitti L

更新日期：2004-12-01 00:00:00

abstract：:The regeneration of lost periodontal ligament (PDL) and alveolar bone is the purpose of periodontal tissue engineering. The goal of the present study was to assess the suitability of 3 odontogenic progenitor populations from dental pulp, PDL, and dental follicle for periodontal regeneration when exposed to natural and...

journal_title：Stem cells and development

authors： Dangaria SJ,Ito Y,Luan X,Diekwisch TG

更新日期：2011-10-01 00:00:00

abstract：:Expression of the transcription factor Snail is required for normal vasculogenesis in the developing mouse embryo. In addition, tumors expressing Snail have been associated with a more malignant phenotype, with both increased invasive properties and angiogenesis. Although the relationship between Snail and vasculogene...

journal_title：Stem cells and development

authors： Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Murphy KM

更新日期：2012-01-20 00:00:00

abstract：:Recent studies have focused on transcriptional regulation and gene expression profiling of human embryonic stem cells (hESCs). However, little information is available regarding the relationship between RNA expression and transcriptional regulation, which is critical in the complete understanding of pluripotency and d...

journal_title：Stem cells and development

authors： Player A,Wang Y,Bhattacharya B,Rao M,Puri RK,Kawasaki ES

更新日期：2006-06-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) possess a distinct ability to perpetuate through self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. A better understanding of the molecular mechanisms by which HSCs replicate and differentiate from the perspective of developing ne...

journal_title：Stem cells and development

authors： Sharma S,Gurudutta GU,Satija NK,Pati S,Afrin F,Gupta P,Verma YK,Singh VK,Tripathi RP

更新日期：2006-12-01 00:00:00

abstract：:Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by defined factors. However, substantial cell numbers subjected to iPSC induction stray from the main reprogramming route and are immortalized as partial iPSCs. These partial iPSCs can become genuine iPSCs by exposure to the ground state condi...

journal_title：Stem cells and development

authors： Kamon M,Katano M,Hiraki-Kamon K,Hishida T,Nakachi Y,Mizuno Y,Okazaki Y,Suzuki A,Hirasaki M,Ueda A,Nishimoto M,Kato H,Okuda A

更新日期：2014-09-15 00:00:00

abstract：:To better understand the basis of variation in cellular reprogramming, we performed experiments with two primary objectives: first, to determine the degree of difference, if any, in reprogramming efficiency among cells lines of a similar type after accounting for technical variables, and second, to compare the efficie...

journal_title：Stem cells and development

authors： Alicea B,Murthy S,Keaton SA,Cobbett P,Cibelli JB,Suhr ST

更新日期：2013-10-01 00:00:00

abstract：:The central role of calcium influx and electrical activity in embryonic development raises important questions about the role and regulation of voltage-dependent calcium influx. Using cultured neural progenitor cell (NPC) preparations, we recorded barium currents through voltage-activated channels using the whole-cell...

journal_title：Stem cells and development

authors： Louhivuori LM,Louhivuori V,Wigren HK,Hakala E,Jansson LC,Nordström T,Castrén ML,Akerman KE

更新日期：2013-04-15 00:00:00

abstract：:Erythropoietin (Epo) may be considered as an endogenous stimulator of vessel growth during tumor progression through an autocrine and/or paracrine loop. The vascular effects of Epo would be relevant in tumor angiogenesis and the negative effect of Epo on tumor growth may be aggravated by its angiogenic activity. The m...

journal_title：Stem cells and development

authors： Ribatti D

更新日期：2010-01-01 00:00:00