Stimulating the neurotrophic and angiogenic properties of human adipose-derived stem cells enhances nerve repair.

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:Occupational asthma (OA) is characterized by allergic airway inflammation and hyperresponsiveness, leading to progressive airway remodeling and a concomitant decline in lung function. The management of OA remains suboptimal in clinical practice. Thus, establishing effective therapies might overcome the natural history...

journal_title：Stem cells and development

authors： Martínez-González I,Cruz MJ,Moreno R,Morell F,Muñoz X,Aran JM

更新日期：2014-10-01 00:00:00

abstract：:Immunodeficient mice transplanted with human hematopoietic stem cells (HSCs) have been referred to as "Human Immune System" (HIS) mice and are a translational platform for studying human immune responses in vivo. Human HSC sources used in generating HIS mice include fetal liver (FL), umbilical cord blood (CB), and adu...

journal_title：Stem cells and development

authors： Walker JA,Vuyyuru R,Manser T,Alugupalli KR

更新日期：2017-12-01 00:00:00

abstract：:Recent studies have revealed that mesenchymal stem cells (MSCs) have a great potential in therapeutic applications. The low efficiency of MSC recruitment and homing to sites of diseased organ tissue, however, remains a major hurdle in their application for treatment of diseases. Stress is commonly associated with vari...

journal_title：Stem cells and development

authors： Zhang S,Lv C,Yang X,Han Z,Zhang S,Zhang J,Zong C,Gao L,Li L,Zhao Q,Li R,Yang Y,Yu F,Li X,Zhang P,Wei L

更新日期：2015-03-01 00:00:00

abstract：:The development of the heart is essential for embryogenesis and precedes development of other organs. However, the mechanisms involved in embryonic cardiac development are ill-defined. Recent evidence suggests that Smad and Wnt signaling pathways are important in stem cell fate determination and their commitment to ca...

journal_title：Stem cells and development

authors： Pal R,Khanna A

更新日期：2006-02-01 00:00:00

abstract：:Novel cell-based and gene therapies represent promising approaches for the treatment of incurable diseases, including cancer. Following the success of the hematopoietic stem cell-based transplantation, other populations of adult progenitor cells, including mesenchymal stem cells (MSCs), have been identified as powerfu...

journal_title：Stem cells and development

authors： Ciavarella S,Dominici M,Dammacco F,Silvestris F

更新日期：2011-01-01 00:00:00

abstract：:In the past few years research on stem cells has exploded as a tool to develop potential therapies to treat incurable neurodegenerative diseases. Stem cell transplantation has been effective in several animal models, but the underlying restorative mechanisms are still unknown. Several events such as cell fusion, neuro...

journal_title：Stem cells and development

authors： Cova L,Ratti A,Volta M,Fogh I,Cardin V,Corbo M,Silani V

更新日期：2004-02-01 00:00:00

abstract：:Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic printing. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using chromatin immunoprecipitation (ChIP)-polymerase chain reaction and ChI...

journal_title：Stem cells and development

authors： Leschik J,Caron L,Yang H,Cowan C,Pucéat M

更新日期：2015-02-01 00:00:00

abstract：:Induced pluripotent stem cell (iPSC) reprogramming requires sustained expression of multiple reprogramming factors for a limited period of time (10-30 days). Conventional iPSC reprogramming was achieved using lentiviral or simple retroviral vectors. Retroviral reprogramming has flaws of insertional mutagenesis, uncont...

journal_title：Stem cells and development

authors： Hu K

更新日期：2014-06-15 00:00:00

abstract：:Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...

journal_title：Stem cells and development

authors： Helm A,Arrizabalaga O,Pignalosa D,Schroeder IS,Durante M,Ritter S

更新日期：2016-01-15 00:00:00

abstract：:Human embryonic stem cells (hESCs) are derived from the inner cell mass (ICM) of the blastocyst and can differentiate into any cell type in the human body. These cells hold a great potential for regenerative medicine, but to obtain enough cells needed for medical treatment, culture is required on a large scale. In the...

journal_title：Stem cells and development

authors： Jensen PL,Beck HC,Petersen J,Hreinsson J,Wånggren K,Laursen SB,Sørensen PD,Christensen ST,Andersen CY

更新日期：2013-04-01 00:00:00

abstract：:Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous system, and induced pluripotent stem cells (iPSCs) are envisioned to b...

journal_title：Stem cells and development

authors： Umebayashi D,Coles B,van der Kooy D

更新日期：2016-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be mobilized from the bone marrow and enter the circulation. Conversely, MSCs can be recruited from the circulation and into the bone marrow. For these migratory pathways, MSCs have to traverse the bone marrow endothelium, in a basal-to-apical and apical-to-basal direction, respective...

journal_title：Stem cells and development

authors： Smith H,Whittall C,Weksler B,Middleton J

更新日期：2012-02-10 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) show great potential for clinical and experimental use due to their capacity to self-renew and differentiate into multiple mesenchymal lineages. However, disadvantages of primary cultures of hMSCs are the limited in vitro lifespan, and the variable properties of cells from diffe...

journal_title：Stem cells and development

authors： Skårn M,Noordhuis P,Wang MY,Veuger M,Kresse SH,Egeland EV,Micci F,Namløs HM,Håkelien AM,Olafsrud SM,Lorenz S,Haraldsen G,Kvalheim G,Meza-Zepeda LA,Myklebost O

更新日期：2014-10-01 00:00:00

abstract：:The chemokine stromal cell-derived factor (SDF)-1α/CXCL12 and its receptor CXC chemokine receptor 4 (CXCR4) play a crucial role in the homing/engraftment and retention of hematopoietic stem/progenitor cells (HSPCs) in the bone marrow. It has been shown using the viral gene transfer technique that CXCR4 overexpression ...

journal_title：Stem cells and development

authors： Gul-Uludag H,Xu P,Marquez-Curtis LA,Xing J,Janowska-Wieczorek A,Chen J

更新日期：2012-07-01 00:00:00

abstract：:Embryonic stem cell (ESC) research gave rise to the possibility that stem cell therapy could be used in the treatment of incurable diseases such as neurodegenerative disorders. However, problems related to the tumorigenicity of undifferentiated ESCs must be resolved before such cells can be used in the application of ...

journal_title：Stem cells and development

authors： Park KD,Seong SK,Park YM,Choi Y,Park JH,Lee SH,Baek DH,Kang JW,Choi KS,Park SN,Kim DS,Kim SH,Kim HS

更新日期：2011-01-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have the capacity to form all the tissues in the body and hence, directed differentiation of ESCs along specific lineages represents a means to generate therapeutically useful cell types. It has been postulated that, during in vitro differentiation, ES cells sequentially pass through simila...

journal_title：Stem cells and development

authors： Mossman AK,Sourris K,Ng E,Stanley EG,Elefanty AG

更新日期：2005-12-01 00:00:00

abstract：:The hedgehog (Hh) signaling pathway plays fundamental roles during embryonic development and tumorigenesis. Previously, we have shown that ablation of the tumor suppressor and negative regulator, Suppressor of fused (Sufu), within this pathway causes embryonic lethality around E9.5 in the mouse. In this study, we exam...

journal_title：Stem cells and development

authors： Hoelzl MA,Heby-Henricson K,Bilousova G,Rozell B,Kuiper RV,Kasper M,Toftgård R,Teglund S

更新日期：2015-11-01 00:00:00

abstract：:The CD34 surface antigen has been recognized as a marker of hematopoietic stem cells (HSCs) and is widely used for HSC selection as well as for quality control in HSC transplantation. CD34 has been implicated in cytoadhesion signaling, and its expression has been suggested to reflect the activation state of hematopoie...

journal_title：Stem cells and development

authors： Lange C,Li Z,Fang L,Baum C,Fehse B

更新日期：2007-04-01 00:00:00

abstract：:Small molecules (SM) can greatly enhance the efficiency of induced pluripotent stem (iPS) cell generation, but the mechanisms by which they act have not been fully explored. We show here that an SM cocktail (NaB, PD03259, and SB431542) significantly promotes iPS cell generation from human fibroblasts, and NaB is more ...

journal_title：Stem cells and development

authors： Zhang Z,Wu WS

更新日期：2013-08-15 00:00:00

abstract：:Since human mesenchymal stem cells (MSCs) are therapeutically attractive for tissue regeneration and repair, we examined the physiological responses of human umbilical cord blood-derived MSCs (hUCB-MSCs) to genotoxic stress. We found that that sublethal doses of reactive oxygen species (ROS) and ionizing radiation cau...

journal_title：Stem cells and development

authors： Ko E,Lee KY,Hwang DS

更新日期：2012-07-20 00:00:00

abstract：:Stem cell factor (SCF) stimulation of the receptor tyrosine kinase c-kit has effects on the proliferation, differentiation, and apoptotic regulation of hematopoietic progenitor cell populations. Rat bone marrow myelomonocytic stem cells (MSC) isolated in vitro by wheat germ agglutinin culture exclusively undergo self-...

journal_title：Stem cells and development

authors： Lucas T,Pratscher B,Fink D,Wolschek M,Samorapoompichit P,Schöfer C,Pehamberger H,Müller M,Sorensen P,Jansen B

更新日期：2005-10-01 00:00:00

abstract：:The secretome of human amniotic fluid stem cells (AFSCs) has great potential as a therapeutic agent in regenerative medicine. However, it must be produced in a clinically compliant manner before it can be used in humans. In this study, we developed a means of producing a biologically active secretome from AFSCs that i...

journal_title：Stem cells and development

authors： Mellows B,Mitchell R,Antonioli M,Kretz O,Chambers D,Zeuner MT,Denecke B,Musante L,Ramachandra DL,Debacq-Chainiaux F,Holthofer H,Joch B,Ray S,Widera D,David AL,Huber TB,Dengjel J,De Coppi P,Patel K

更新日期：2017-09-15 00:00:00

abstract：:The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a complex process that involves significant epigenetic alterations in the reprogrammed cells. Epigenetic modifiers such as histone deacetylase (HDAC) inhibitors have been shown to increase the efficiency of derivation of iPSCs in humans an...

journal_title：Stem cells and development

authors： Petkov S,Glage S,Nowak-Imialek M,Niemann H

更新日期：2016-03-01 00:00:00

abstract：:Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors inf...

journal_title：Stem cells and development

authors： Aked J,Delavaran H,Lindvall O,Norrving B,Kokaia Z,Lindgren A

更新日期：2017-04-15 00:00:00

abstract：:Lymphedema is a medically irreversible condition for which currently conservative and surgical therapies are either ineffective or impractical. The potential use of progenitor and stem cell-based therapies has offered a paradigm that may provide alternative treatment options for lymphatic disorders. Moreover, basic re...

journal_title：Stem cells and development

authors： Qi S,Pan J

更新日期：2015-02-01 00:00:00

abstract：:The development of methods to induce differentiation of human mesenchymal stem cells (hMSCs) has opened the possibility of using these cells in regenerative or reparative therapies. However, the low frequency of hMSCs in tissue means it is often necessary to expand these cells extensively in vitro. In this study, we e...

journal_title：Stem cells and development

authors： Khoo ML,Shen B,Tao H,Ma DD

更新日期：2008-10-01 00:00:00

abstract：:The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration ...

journal_title：Stem cells and development

authors： Cousins FL,O DF,Ong YR,Breault DT,Deane JA,Gargett CE

更新日期：2019-01-01 00:00:00

abstract：:Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we analyzed in this randomized, controlled study the influence of intracoronary autologous freshly isolated bone marrow cell...

journal_title：Stem cells and development

authors： Turan RG,Bozdag-Turan I,Ortak J,Akin I,Kische S,Schneider H,Turan CH,Rehders TC,Rauchhaus M,Kleinfeldt T,Adolph E,Brehm M,Yokus S,Steiner S,Sahin K,Nienaber CA,Ince H

更新日期：2011-09-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00