Betacellulin overexpression in mesenchymal stem cells induces insulin secretion in vitro and ameliorates streptozotocin-induced hyperglycemia in rats.

abstract：:The projected annual demand for stem cell-based dental treatments in the United States can range from over 290 million tooth restorative treatments to 30,000 patients requiring tissue regeneration following craniofacial cancer surgery. Professional dental treatments cost Americans over $60 billion per year. Scientific...

journal_title：Stem cells and development

authors： Garcia-Godoy F,Murray PE

更新日期：2006-12-01 00:00:00

abstract：:Embryonic stem (ES) cells are recognized as an excellent cell culture model for studying developmental mechanisms and their therapeutic modulations. The aim of this work was to define whether using magnetofection was an efficient way to manipulate stem cells genetically without adversely affecting their proliferation ...

journal_title：Stem cells and development

authors： Lee CH,Kim EY,Jeon K,Tae JC,Lee KS,Kim YO,Jeong MY,Yun CW,Jeong DK,Cho SK,Kim JH,Lee HY,Riu KZ,Cho SG,Park SP

更新日期：2008-02-01 00:00:00

abstract：:Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently,...

journal_title：Stem cells and development

authors： Marfia G,Navone SE,Hadi LA,Paroni M,Berno V,Beretta M,Gualtierotti R,Ingegnoli F,Levi V,Miozzo M,Geginat J,Fassina L,Rampini P,Tremolada C,Riboni L,Campanella R

更新日期：2016-07-15 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating medical condition with profound social and economic impacts. Although research is ongoing, current treatment options are limited and do little to restore functionality. However, recent studies suggest that mesenchymal stem cell-derived exosomes (MSC-exosomes) may hold the key ...

journal_title：Stem cells and development

authors： Ren Z,Qi Y,Sun S,Tao Y,Shi R

更新日期：2020-12-01 00:00:00

abstract：:There are a limited number of therapies available to prevent heart failure following myocardial infarction. One novel therapy that is currently being pursued is the implantation of cardiac progenitor cells (CPCs); however, their responses to oxidative stress during differentiation have yet to be elucidated. The object...

journal_title：Stem cells and development

authors： Pendergrass KD,Boopathy AV,Seshadri G,Maiellaro-Rafferty K,Che PL,Brown ME,Davis ME

更新日期：2013-09-01 00:00:00

abstract：:Members of the homeobox (Hox) gene family are known to mediate expansion of hematopoietic stem cells (HSCs) and progenitors. The absence of oncogenic properties promoted HOXB4 as prime candidate in the quest to expand HSCs for clinical purposes. Despite its potential to expand HSCs, studies with mutant mice showed tha...

journal_title：Stem cells and development

authors： Fournier M,Lebert-Ghali CÉ,Krosl G,Bijl JJ

更新日期：2012-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) possess a distinct ability to perpetuate through self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. A better understanding of the molecular mechanisms by which HSCs replicate and differentiate from the perspective of developing ne...

journal_title：Stem cells and development

authors： Sharma S,Gurudutta GU,Satija NK,Pati S,Afrin F,Gupta P,Verma YK,Singh VK,Tripathi RP

更新日期：2006-12-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration ...

journal_title：Stem cells and development

authors： Cousins FL,O DF,Ong YR,Breault DT,Deane JA,Gargett CE

更新日期：2019-01-01 00:00:00

abstract：:Bone marrow (BM)-derived mesenchymal stromal cells (MSCs) frequently display alterations in several hematologic disorders, such as acute lymphoid leukemia, acute myeloid leukemia (AML), and myelodysplastic syndromes. In acute leukemias, it is not clear whether MSC alterations contribute to the development of the malig...

journal_title：Stem cells and development

authors： Desbourdes L,Javary J,Charbonnier T,Ishac N,Bourgeais J,Iltis A,Chomel JC,Turhan A,Guilloton F,Tarte K,Demattei MV,Ducrocq E,Rouleux-Bonnin F,Gyan E,Hérault O,Domenech J

更新日期：2017-05-15 00:00:00

abstract：:The hedgehog (Hh) signaling pathway plays fundamental roles during embryonic development and tumorigenesis. Previously, we have shown that ablation of the tumor suppressor and negative regulator, Suppressor of fused (Sufu), within this pathway causes embryonic lethality around E9.5 in the mouse. In this study, we exam...

journal_title：Stem cells and development

authors： Hoelzl MA,Heby-Henricson K,Bilousova G,Rozell B,Kuiper RV,Kasper M,Toftgård R,Teglund S

更新日期：2015-11-01 00:00:00

abstract：:Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demo...

journal_title：Stem cells and development

authors： Christensen C,Zhang S,Roelink H

更新日期：2006-10-01 00:00:00

abstract：:In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. CD3(+) cells were separated by direct antibody-coupled magnetic beads, followed by DNA extraction according to a stan...

journal_title：Stem cells and development

authors： Uzunel M,Sairafi D,Remberger M,Mattsson J,Uhlin M

更新日期：2014-07-15 00:00:00

abstract：:In spina bifida, the neural tube fails to close during the embryonic period. Exposure of the neural tube to the amniotic fluid during pregnancy causes additional neural damage. Intrauterine tissue engineering using a biomaterial seeded with stem cells might prevent this additional damage. For this purpose, autologous ...

journal_title：Stem cells and development

authors： Hosper NA,Bank RA,van den Berg PP

更新日期：2014-03-01 00:00:00

abstract：:Most disease-modifying therapeutic approaches in Alzheimer's disease (AD) aim to reduce the accumulation of neurotoxic amyloid-beta (Abeta) peptides as a hallmark of AD pathogenesis. Here we report the in vitro basis for a potential autologous stem cell-based strategy for widespread delivery of enzymatic activities ag...

journal_title：Stem cells and development

authors： Habisch HJ,Schmid B,von Arnim CA,Ludolph AC,Brenner R,Storch A

更新日期：2010-05-01 00:00:00

abstract：:Nonpluripotent neural progenitor cells (NPCs) derived from the human fetal central nervous system were found to express a number of messenger RNA (mRNA) species associated with pluripotency, such as NANOG, REX1, and OCT4. The expression was restricted to small subpopulations of NPCs. In contrast to pluripotent stem ce...

journal_title：Stem cells and development

authors： Vincent PH,Benedikz E,Uhlén P,Hovatta O,Sundström E

更新日期：2017-06-15 00:00:00

abstract：:With an incidence of ∼1:3,500 to 5,000 in male children, Duchenne muscular dystrophy (DMD) is an X-linked disorder in which progressive muscle degeneration occurs and affected boys usually die in their twenties or thirties. Cardiac involvement occurs in 90% of patients and heart failure accounts for up to 40% of death...

journal_title：Stem cells and development

authors： Dick E,Kalra S,Anderson D,George V,Ritso M,Laval SH,Barresi R,Aartsma-Rus A,Lochmüller H,Denning C

更新日期：2013-10-15 00:00:00

abstract：:The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...

journal_title：Stem cells and development

authors： Rüster B,Grace B,Seitz O,Seifried E,Henschler R

更新日期：2005-04-01 00:00:00

abstract：:Müller glia are responsible for the retina regeneration observed in zebrafish. Although the human retina harbors Müller glia with stem cell characteristics, there is no evidence that they regenerate the retina after disease or injury. Transforming growth factor-β (TGFβ) and Wnt signaling regulate retinal neurogenesis ...

journal_title：Stem cells and development

authors： Angbohang A,Wu N,Charalambous T,Eastlake K,Lei Y,Kim YS,Sun XH,Limb GA

更新日期：2016-01-01 00:00:00

abstract：:Bone marrow human mesenchymal stem cells (hMSCs) are known to survive in serum-free media, when most normal somatic cells do not survive. We found that the endogenously-activated bone morphogenetic protein (BMP) pathway is involved in this cellular behavior. Under this culture condition, phosphorylated Smad1 (PSmad1),...

journal_title：Stem cells and development

authors： Solmesky LJ,Abekasis M,Bulvik S,Weil M

更新日期：2009-11-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) self-renew indefinitely as highly organized pluripotent colonies. Unlike mouse pluripotent stem cell colonies, human colonies form a uniform, flat, epithelium-like monolayer. Interestingly, it has been reported that colony morphology is closely correlated with the maintenance of plur...

journal_title：Stem cells and development

authors： Kim JM,Moon SH,Park SJ,Lee HY,Hong KS,Seo J,Bae YS,Chung HM

更新日期：2013-01-15 00:00:00

abstract：:Smooth muscle cell (SMC) differentiation and dedifferentiation play a critical role in the pathogenesis of cardiovascular diseases. The lack of a good and simple in vitro SMC differentiation system has hampered the progress of SMC field for years. The generation of such an in vitro system would be invaluable for explo...

journal_title：Stem cells and development

authors： Xie CQ,Huang H,Wei S,Song LS,Zhang J,Ritchie RP,Chen L,Zhang M,Chen YE

更新日期：2009-06-01 00:00:00

abstract：:The mental retardation-associated protein, srGAP3 is highly expressed in neurogenic sites. It is thought to regulate the key aspects of neuronal development and functions. Little is known about the interaction between srGAP3 and immature neural stem cells/neural progenitor cells (NSCs/NPCs). In the current study, the ...

journal_title：Stem cells and development

authors： Lu H,Jiao Q,Wang Y,Yang Z,Feng M,Wang L,Chen X,Jin W,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:Small-molecule inhibitors of glycogen synthase kinase 3β (GSK3β) have demonstrated strong anti-leukemia effects in preclinical studies. Here, we investigated the effect of GSK3β inhibitor 6-Bromoindirubin-3-oxime (BIO) previously shown to inhibit leukemia cell growth in vitro and of animal models on hematopoietic rege...

journal_title：Stem cells and development

authors： Shen S,Xu N,Klamer G,Ko KH,Khoo M,Ma D,Moore J,O'Brien TA,Dolnikov A

更新日期：2015-03-15 00:00:00

abstract：:Many of the currently established human embryonic stem (hES) cell lines have been characterized extensively in terms of their gene expression profiles and genetic stability in culture. Recent studies have indicated that microRNAs (miRNAs), a class of noncoding small RNAs that participate in the regulation of gene expr...

journal_title：Stem cells and development

authors： Lakshmipathy U,Love B,Goff LA,Jörnsten R,Graichen R,Hart RP,Chesnut JD

更新日期：2007-12-01 00:00:00

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy for repair of the diseased/injured central nervous system (CNS); however, controlling their differentiation remains a significant hurdle. This study is aimed at controlling differentiation and specifically at screening exogenous factors to...

journal_title：Stem cells and development

authors： Zahir T,Chen YF,MacDonald JF,Leipzig N,Tator CH,Shoichet MS

更新日期：2009-12-01 00:00:00

abstract：:Regenerative medicine is in demand of adult pluripotent stem cells (PSCs). The "Bonghan System (BHS)" was discovered and suggested to contain cells with regenerative capacity in the early 1960s. It had been ignored for a long time due to the lack of sufficient details of experiments, but about 37 years after the initi...

journal_title：Stem cells and development

authors： Rai R,Chandra V,Kwon BS

更新日期：2015-10-01 00:00:00

abstract：:Occupational asthma (OA) is characterized by allergic airway inflammation and hyperresponsiveness, leading to progressive airway remodeling and a concomitant decline in lung function. The management of OA remains suboptimal in clinical practice. Thus, establishing effective therapies might overcome the natural history...

journal_title：Stem cells and development

authors： Martínez-González I,Cruz MJ,Moreno R,Morell F,Muñoz X,Aran JM

更新日期：2014-10-01 00:00:00

abstract：:Novel cell-based and gene therapies represent promising approaches for the treatment of incurable diseases, including cancer. Following the success of the hematopoietic stem cell-based transplantation, other populations of adult progenitor cells, including mesenchymal stem cells (MSCs), have been identified as powerfu...

journal_title：Stem cells and development

authors： Ciavarella S,Dominici M,Dammacco F,Silvestris F

更新日期：2011-01-01 00:00:00