Abstract:
:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after established lung injury in adulthood is clinically relevant, but currently unknown. Experimental BPD was achieved by exposing newborn rats to 95% O2 from postnatal days 4-14. Human umbilical cord-derived MSCs were intratracheally administered to rats (1 × 106cells/kg body weight) as a single dose at 3 or 6 months of age followed by assessment at 5 or 8 months of age, respectively. Lung alveolar structure and vessel density were histologically analyzed. O2-exposed rats exhibited persistent lung injury characterized by arrested alveolar growth with airspace enlargement and a lower vessel density at both 5 and 8 months of age compared with controls. Single-dose MSC treatment at 3 months partially attenuated O2-induced alveolar injury and restored vessel density at 5 months. Treatment with a single dose at 6 months did not attenuate alveolar injury or vessel density at 8 months. However, treatment with multiple MSC doses at 6, 6.5, 7, and 7.5 months significantly attenuated alveolar injury and improved vessel density at 8 months of age. Treatment of the adult BPD lung with MSCs has the potential to improve lung injury if administered in multiple doses or at an early stage of adulthood.
journal_name
Stem Cells Devjournal_title
Stem cells and developmentauthors
O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud Bdoi
10.1089/scd.2019.0116subject
Has Abstractpub_date
2020-03-15 00:00:00pages
364-371issue
6eissn
1547-3287issn
1557-8534journal_volume
29pub_type
杂志文章abstract::Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodo...
journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章,评审
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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doi:10.1089/scd.2013.0388
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journal_title:Stem cells and development
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doi:10.1089/scd.2007.0051
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journal_title:Stem cells and development
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doi:10.1089/scd.2008.0383
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2004.13.362
更新日期:2004-08-01 00:00:00
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journal_title:Stem cells and development
pub_type: 杂志文章,评审
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2013.0083
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2011.0259
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