Abstract:
:Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. In this study, we show that Sca-1+Lin-CD117-MSCs restrain the lipopolysaccharide-stimulated maturation transition of imDCs cocultured without exogenous cytokines. The Notch signaling pathway plays a critical role in the process by controlling interferon regulatory factor 8 (IRF8) expression in an RBP-J-dependent manner. We observed a high degree of H3K27me3 modification mediated by SUZ12 and a relatively low degree of H3K4me3 modification regulated by WDR5 at the IRF8 promoter during coculture. These data reveal a possible mechanism by which Sca-1+Lin-CD117-MSCs modulate imDC maturation and further support the role of MSCs in treating immune disorders.
journal_name
Stem Cells Devjournal_title
Stem cells and developmentauthors
Liu X,Ren S,Ge C,Cheng K,Li X,Zhao RCdoi
10.1089/scd.2017.0235subject
Has Abstractpub_date
2018-04-15 00:00:00pages
556-565issue
8eissn
1547-3287issn
1557-8534journal_volume
27pub_type
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章,评审
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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doi:10.1089/scd.2010.0425
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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