Id proteins facilitate self-renewal and proliferation of neural stem cells.

abstract：:Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. However, it is essential to unde...

journal_title：Stem cells and development

authors： Tatebayashi K,Tanaka Y,Nakano-Doi A,Sakuma R,Kamachi S,Shirakawa M,Uchida K,Kageyama H,Takagi T,Yoshimura S,Matsuyama T,Nakagomi T

更新日期：2017-06-01 00:00:00

abstract：:Non-tumorous liver tissue removed during surgery to resect hepatocellular carcinoma (HCC) is potentially a useful source of material from which cells, particularly liver progenitor/stem cells (LPCs), can be isolated to establish cell lines. The purpose of this study was to evaluate the applicability of the "plate-and-...

journal_title：Stem cells and development

authors： Zhang A,London R,Schulz FM,Giguère-Simmonds PW,Delriviere L,Chandraratana H,Hardy K,Zheng S,Olynyk JK,Yeoh G

更新日期：2010-08-01 00:00:00

abstract：:Cardiac stem/progenitors are being used in the clinic to treat patients with a range of cardiac pathologies. However, improvements in heart function following treatment have been reported to be variable, with some showing no response. This discrepancy in response remains unresolved. Mesenchymal stem cells (MSCs) have ...

journal_title：Stem cells and development

authors： Oldershaw R,Owens WA,Sutherland R,Linney M,Liddle R,Magana L,Lash GE,Gill JH,Richardson G,Meeson A

更新日期：2019-05-01 00:00:00

abstract：:We have isolated a novel progenitor cell population from adult rat pancreatic ducts, termed pancreatic-derived progenitor cells (PDPCs). Here, we report the in vitro culture, selection, and characterization of Thy1.1-positive and Thy1.1-negative PDPC subpopulations. These cells exhibit bipotentiality for differentiati...

journal_title：Stem cells and development

authors： Stevenson KS,McGlynn L,Hodge M,McLinden H,George WD,Davies RW,Shiels PG

更新日期：2009-12-01 00:00:00

abstract：:Dental follicle stem cells (DFSCs), which are the stem cells present in the dental follicle tissue of the tooth germ and are derived from the neural crest, are direct precursor cells of periodontal tissues and can form the periodontal ligament, cementum, and alveolar bone proper in the late stage of tooth development....

journal_title：Stem cells and development

authors： Zhang J,Ding H,Liu X,Sheng Y,Liu X,Jiang C

更新日期：2019-08-01 00:00:00

abstract：:Immunodeficient mice transplanted with human hematopoietic stem cells (HSCs) have been referred to as "Human Immune System" (HIS) mice and are a translational platform for studying human immune responses in vivo. Human HSC sources used in generating HIS mice include fetal liver (FL), umbilical cord blood (CB), and adu...

journal_title：Stem cells and development

authors： Walker JA,Vuyyuru R,Manser T,Alugupalli KR

更新日期：2017-12-01 00:00:00

abstract：:Halting the first clinical trial on the use of embryonic stem cell derivatives for spinal cord injury resulted in disappointment and created concerns about the future use of pluripotent stem cell-based therapy in the treatment of human diseases. This article presents reflections and concerns related to the halted embr...

journal_title：Stem cells and development

authors： Lukovic D,Stojkovic M,Moreno-Manzano V,Bhattacharya SS,Erceg S

更新日期：2014-01-01 00:00:00

abstract：:Stromal cells have been used to induce dopaminergic differentiation of mouse, primate, and human embryonic stem cells (hESCs), but the mechanism that governs this induction is unknown. In this manuscript, we show that medium conditioned by the stromal cell line PA6 (PA6-CM) can induce dopaminergic differentiation in n...

journal_title：Stem cells and development

authors： Swistowska AM,da Cruz AB,Han Y,Swistowski A,Liu Y,Shin S,Zhan M,Rao MS,Zeng X

更新日期：2010-01-01 00:00:00

abstract：:Liver transplantation is the only radical treatment for decompensated cirrhosis, but its use is limited owing to a shortage of donors; hence, there is an urgent need for new treatments. Previously, we developed a liver-regeneration therapy using autologous bone marrow-derived mesenchymal stem cells (BMSCs), which is u...

journal_title：Stem cells and development

authors： Nishi M,Matsumoto T,Fujisawa K,Suehiro Y,Takami T,Yamamoto N,Yamasaki T,Sakaida I

更新日期：2020-11-15 00:00:00

abstract：:Periodontitis is an infectious disease characterized by chronic inflammation and progressive destruction of periodontal tissues. Chronic inflammatory environment may affect immunomodulatory function of periodontal ligament stem cells (PDLSCs) and promote shift toward proinflammatory phenotype contributing to propagati...

journal_title：Stem cells and development

authors： Čebatariūnienė A,Kriaučiūnaitė K,Prunskaitė J,Tunaitis V,Pivoriūnas A

更新日期：2019-08-01 00:00:00

abstract：:Lifelong neurogenesis in the mouse olfactory epithelium (OE) is regulated by the response of stem/progenitor cells to local signals, but embryonic and adult OE progenitors appear to be quite different--with potentially different mechanisms of regulation. A recently identified progenitor unique to embryonic OE--the nes...

journal_title：Stem cells and development

authors： Murdoch B,Roskams AJ

更新日期：2013-02-15 00:00:00

abstract：:Embryonic stem (ES) cells are recognized as an excellent cell culture model for studying developmental mechanisms and their therapeutic modulations. The aim of this work was to define whether using magnetofection was an efficient way to manipulate stem cells genetically without adversely affecting their proliferation ...

journal_title：Stem cells and development

authors： Lee CH,Kim EY,Jeon K,Tae JC,Lee KS,Kim YO,Jeong MY,Yun CW,Jeong DK,Cho SK,Kim JH,Lee HY,Riu KZ,Cho SG,Park SP

更新日期：2008-02-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:Embryonic stem cells (ESCs) have the capacity to form all the tissues in the body and hence, directed differentiation of ESCs along specific lineages represents a means to generate therapeutically useful cell types. It has been postulated that, during in vitro differentiation, ES cells sequentially pass through simila...

journal_title：Stem cells and development

authors： Mossman AK,Sourris K,Ng E,Stanley EG,Elefanty AG

更新日期：2005-12-01 00:00:00

abstract：:The generation of Schwann cells from precursors within adult skin and bone marrow is of significant clinical interest because of the opportunities for disease modelling and strategies for remyelination. Recent evidence has suggested that glial cells can be generated from (i) mesenchymal stem cells (MSCs) within adult ...

journal_title：Stem cells and development

authors： Hunt DP,Sajic M,Phillips H,Henderson D,Compston A,Smith K,Chandran S

更新日期：2010-07-01 00:00:00

abstract：:The secretome of human amniotic fluid stem cells (AFSCs) has great potential as a therapeutic agent in regenerative medicine. However, it must be produced in a clinically compliant manner before it can be used in humans. In this study, we developed a means of producing a biologically active secretome from AFSCs that i...

journal_title：Stem cells and development

authors： Mellows B,Mitchell R,Antonioli M,Kretz O,Chambers D,Zeuner MT,Denecke B,Musante L,Ramachandra DL,Debacq-Chainiaux F,Holthofer H,Joch B,Ray S,Widera D,David AL,Huber TB,Dengjel J,De Coppi P,Patel K

更新日期：2017-09-15 00:00:00

abstract：:Body axes and germ layers evolve at gastrulation, and in mammals are driven by many genes; however, what orchestrates the genetic pathways during gastrulation remains elusive. Previously, we presented evidence that microRNA-17 (miRNA-17) family members, miR-17-5p, miR-20a, miR-93, and miR-106a were differentially expr...

journal_title：Stem cells and development

authors： Larabee SM,Coia H,Jones S,Cheung E,Gallicano GI

更新日期：2015-02-01 00:00:00

abstract：:We describe a rapid and efficient 5-step program of defined factors for the genesis of brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells (ESCs). The OLs emerge on the same time frame in vitro as seen in vivo. Factors promoting neural induction (retinoids, noggin) are required, while exogenous Sonic...

journal_title：Stem cells and development

authors： Sadowski D,Kiel ME,Apicella M,Arriola AG,Chen CP,McKinnon RD

更新日期：2010-09-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical respiratory failure disorder associated with chronic pathology and disability and has a mortality rate of 40%-60%. However, the pathogenesis of ARDS/ALI remains unclear, and existing therapeutic options are insufficient for address...

journal_title：Stem cells and development

authors： Wang Y,Li H,Li X,Su X,Xiao H,Yang J

更新日期：2021-02-01 00:00:00

abstract：:The development of methods to induce differentiation of human mesenchymal stem cells (hMSCs) has opened the possibility of using these cells in regenerative or reparative therapies. However, the low frequency of hMSCs in tissue means it is often necessary to expand these cells extensively in vitro. In this study, we e...

journal_title：Stem cells and development

authors： Khoo ML,Shen B,Tao H,Ma DD

更新日期：2008-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) from bone marrow (BM) are widely used for bone and less for cartilage tissue regeneration due to their self-renewal and differentiating properties into osteogenic or chondrogenic lineages. This review considers the last decade of clinical trials involving a two-step procedure, by expandin...

journal_title：Stem cells and development

authors： Veronesi F,Giavaresi G,Tschon M,Borsari V,Nicoli Aldini N,Fini M

更新日期：2013-01-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors suppress bone repair and bone formation by suppressing angiogenesis as well as potentially interfering with osteoblast and osteoclast functions. In spite of these reports, there is a controversy over the exact effects of COX-2 inhibitors on bone formation processes itself. This work...

journal_title：Stem cells and development

authors： Yoon DS,Yoo JH,Kim YH,Paik S,Han CD,Lee JW

更新日期：2010-10-01 00:00:00

abstract：:Here, we describe a focused microarray for screening rat embryonic stem cells (ESCs) and provide validation data that this array can distinguish undifferentiated rat ESCs from rat trophoblast stem (TS) cells, rat extraembryonic endoderm cells, mouse embryonic fibroblast feeder cells, and differentiated rat ESCs. Using...

journal_title：Stem cells and development

authors： Hong J,He H,Bui P,Ryba-White B,Rumi MA,Soares MJ,Dutta D,Paul S,Kawamata M,Ochiya T,Ying QL,Rajanahalli P,Weiss ML

更新日期：2013-02-01 00:00:00

abstract：:Self-renewal and differentiation of endogenous stem cells (SCs) are essential for adult tissue homoeostasis and intrinsic healing capacity. In this study, we hypothesize that penis contains a small population of endogenous SCs, which might help rejuvenation of damaged erectile function. In this study, 60 newborn male ...

journal_title：Stem cells and development

authors： Xu Y,Guan R,Lei H,Gao Z,Li H,Hui Y,Zhou F,Wang L,Lin G,Xin Z

更新日期：2015-03-15 00:00:00

abstract：:The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a complex process that involves significant epigenetic alterations in the reprogrammed cells. Epigenetic modifiers such as histone deacetylase (HDAC) inhibitors have been shown to increase the efficiency of derivation of iPSCs in humans an...

journal_title：Stem cells and development

authors： Petkov S,Glage S,Nowak-Imialek M,Niemann H

更新日期：2016-03-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating medical condition with profound social and economic impacts. Although research is ongoing, current treatment options are limited and do little to restore functionality. However, recent studies suggest that mesenchymal stem cell-derived exosomes (MSC-exosomes) may hold the key ...

journal_title：Stem cells and development

authors： Ren Z,Qi Y,Sun S,Tao Y,Shi R

更新日期：2020-12-01 00:00:00

abstract：:In the mammalian olfactory epithelium (OE), olfactory receptor neurons (ORNs) are continuously regenerated throughout the animal's lifetime. Horizontal basal cells (HBCs) in the OE express the epithelial marker keratin 5 (K5) and the stem cell marker Pax6 and are considered relatively quiescent tissue stem cells in th...

journal_title：Stem cells and development

authors： Suzuki J,Sakurai K,Yamazaki M,Abe M,Inada H,Sakimura K,Katori Y,Osumi N

更新日期：2015-08-15 00:00:00

abstract：:Multipotent skin-derived progenitors (SKPs) can be traced back to embryonic neural crest cells and are able to differentiate into both neural and mesodermal progeny in vitro. Neural stem cells (NSCs) are capable of self-renewing and can contribute to neuron and glia in the nervous system. Recently, we derived porcine ...

journal_title：Stem cells and development

authors： Zhao MT,Yang X,Lee K,Mao J,Teson JM,Whitworth KM,Samuel MS,Spate LD,Murphy CN,Prather RS

更新日期：2012-09-20 00:00:00

abstract：:The enhanced proliferation of mesenchymal stem cells (MSCs) can be helpful for the clinical translation of cell therapy. Low-level laser irradiation (LLLI) has been demonstrated as regulating MSC proliferation. MicroRNAs (miRNAs) are involved in various pathophysiologic processes in stem cells, but the role of miRNAs ...

journal_title：Stem cells and development

authors： Wang J,Huang W,Wu Y,Hou J,Nie Y,Gu H,Li J,Hu S,Zhang H

更新日期：2012-09-01 00:00:00

abstract：:There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hype...

journal_title：Stem cells and development

authors： Aliotta JM,Keaney PJ,Warburton RR,DelTatto M,Dooner MS,Passero MA,Quesenberry PJ,Klinger JR

更新日期：2009-06-01 00:00:00