Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3.

abstract：:The aim of this study was to clarify the mechanisms that regulate hematopoietic cell expansion in vitro by identifying defined culture conditions. We report the results of experiments with CD34(+) cells from cord blood (CB, n = 13), bone marrow (BM, n = 4), and mobilized peripheral blood stem cells (PBSC, n = 5) using...

journal_title：Stem cells and development

authors： Rossi B,Zanolin E,Vincenzi C,Diani F,Pizzolo G,de Wynter E,Nadali G

更新日期：2004-08-01 00:00:00

abstract：:Osteophytes are a distinct feature of osteoarthritis (OA). Their formation may be related to pluripotential cells in the periosteum responding to stimulus during OA. This study aimed to isolate stem cells from osteophyte tissues and to characterize their phenotype, proliferation, and differentiation potential, as well...

journal_title：Stem cells and development

authors： Singh S,Jones BJ,Crawford R,Xiao Y

更新日期：2008-04-01 00:00:00

abstract：:Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC...

journal_title：Stem cells and development

authors： Knorr DA,Bock A,Brentjens RJ,Kaufman DS

更新日期：2013-07-01 00:00:00

abstract：:Regenerative medicine is in demand of adult pluripotent stem cells (PSCs). The "Bonghan System (BHS)" was discovered and suggested to contain cells with regenerative capacity in the early 1960s. It had been ignored for a long time due to the lack of sufficient details of experiments, but about 37 years after the initi...

journal_title：Stem cells and development

authors： Rai R,Chandra V,Kwon BS

更新日期：2015-10-01 00:00:00

abstract：:The central role of calcium influx and electrical activity in embryonic development raises important questions about the role and regulation of voltage-dependent calcium influx. Using cultured neural progenitor cell (NPC) preparations, we recorded barium currents through voltage-activated channels using the whole-cell...

journal_title：Stem cells and development

authors： Louhivuori LM,Louhivuori V,Wigren HK,Hakala E,Jansson LC,Nordström T,Castrén ML,Akerman KE

更新日期：2013-04-15 00:00:00

abstract：:The mammalian inner ear is vulnerable to genetic disorders and aging, as well as to injuries caused by overstimulation, ototoxic drugs, and viral infections. Due to the poor regeneration of the sensory epithelium and the spiral ganglion neurons in the adult mammalian inner ear, cell replacement therapy strategies have...

journal_title：Stem cells and development

authors： Hu Z,Ulfendahl M

更新日期：2006-06-01 00:00:00

abstract：:The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration ...

journal_title：Stem cells and development

authors： Cousins FL,O DF,Ong YR,Breault DT,Deane JA,Gargett CE

更新日期：2019-01-01 00:00:00

abstract：:Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells wer...

journal_title：Stem cells and development

authors： Park BW,Pan B,Toms D,Huynh E,Byun JH,Lee YM,Shen W,Rho GJ,Li J

更新日期：2014-07-15 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The most potent ligand of the AhR known is 2,3,7,8-tetracholorodibenzo-p-dioxin. We previously reported tetrachlorodibenzo-p-dioxin-induced...

journal_title：Stem cells and development

authors： Singh KP,Garrett RW,Casado FL,Gasiewicz TA

更新日期：2011-05-01 00:00:00

abstract：:Ex vivo cultures of human bone marrow-derived mesenchymal stem cells (MSCs) contain subsets of progenitors exhibiting dissimilar properties. One of these subsets comprises uncommitted progenitors displaying distinctive features, such as morphology, a quiescent condition, growth factor production, and restricted tissue...

journal_title：Stem cells and development

authors： Minguell JJ,Fierro FA,Epuñan MJ,Erices AA,Sierralta WD

更新日期：2005-08-01 00:00:00

abstract：:Inducing a stable and predictable program of neural cell fate in pluripotent cells in vitro is an important goal for utilizing these cells for modeling human disease mechanisms. However, the extent to which in vitro neural specification recapitulates in vivo neural specification remains to be fully established. We pre...

journal_title：Stem cells and development

authors： Dang LT,Wong L,Tropepe V

更新日期：2012-10-10 00:00:00

abstract：:The capability to form all cell types of the body is a unique feature of stem cells. However, many questions remain concerning the mechanisms regulating differentiation potential. The derivation of spermatogonial cell lines (SGs) from mouse and human, which can differentiate across germ-layer borders, suggested male g...

journal_title：Stem cells and development

authors： Thoma EC,Wagner TU,Weber IP,Herpin A,Fischer A,Schartl M

更新日期：2011-08-01 00:00:00

abstract：:To understand which growth factors/cytokines can affect migration of mesenchymal stem cells (MSCs) to injured tissues, we compared the effects of many (26) growth factors/cytokines on the migration activity of rabbit and human MSCs using a microchemotaxis chamber. Among them, platelet-derived growth factor (PDGF)-BB, ...

journal_title：Stem cells and development

authors： Ozaki Y,Nishimura M,Sekiya K,Suehiro F,Kanawa M,Nikawa H,Hamada T,Kato Y

更新日期：2007-02-01 00:00:00

abstract：:Primordial germ cells (PGCs), the precursors of gametes, have regulatory mechanisms involving transcription factors and epigenetic modifications. The transcription factor NANOG is a key regulator of germ cell and embryonic stem cell characteristics. However, the epigenetic regulation of NANOG with a histone deacetylas...

journal_title：Stem cells and development

authors： Jung HG,Hwang YS,Park YH,Cho HY,Rengaraj D,Han JY

更新日期：2018-09-01 00:00:00

abstract：:Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe adverse reaction, which results in progressive bone destruction in the maxillofacial region of patients. To date, the pathological mechanisms remain largely unclear. Recently, we found that BRONJ patient had significantly deep periodontal pockets and...

journal_title：Stem cells and development

authors： Li M,Yu Y,Shi Y,Zhou Y,Zhang W,Hua H,Ge J,Zhang Z,Ye D,Yang C,Wang S

更新日期：2020-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be mobilized from the bone marrow and enter the circulation. Conversely, MSCs can be recruited from the circulation and into the bone marrow. For these migratory pathways, MSCs have to traverse the bone marrow endothelium, in a basal-to-apical and apical-to-basal direction, respective...

journal_title：Stem cells and development

authors： Smith H,Whittall C,Weksler B,Middleton J

更新日期：2012-02-10 00:00:00

abstract：:A long-term goal of mesenchymal progenitor cell (MPC) research is to identify cell-surface markers to facilitate MPC isolation. One reported MPC feature in humans and other species is lack of CD14 (lipopolysaccharide receptor) expression. The aim of this study was to evaluate CD14 as an MPC sorting marker. Our hypothe...

journal_title：Stem cells and development

authors： Hackett CH,Flaminio MJ,Fortier LA

更新日期：2011-04-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have the capacity to form all the tissues in the body and hence, directed differentiation of ESCs along specific lineages represents a means to generate therapeutically useful cell types. It has been postulated that, during in vitro differentiation, ES cells sequentially pass through simila...

journal_title：Stem cells and development

authors： Mossman AK,Sourris K,Ng E,Stanley EG,Elefanty AG

更新日期：2005-12-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2) is a novel differentiation factor that is capable of inducing osteoblast differentiation and bone formation, making it an attractive option in treatment of bone defects, fractures, and spine fusions. Inflammation, which was a common situation during bone healing, is recognized to i...

journal_title：Stem cells and development

authors： Huang RL,Yuan Y,Zou GM,Liu G,Tu J,Li Q

更新日期：2014-02-01 00:00:00

abstract：:Regenerative medicine, a paragon of future healthcare, holds unprecedented potential in extending the reach of treatment modalities for individuals across diseases and lifespan. Emerging regenerative technologies, focused on structural repair and functional restoration, signal a radical transformation in medical and s...

journal_title：Stem cells and development

authors： Terzic A,Harper CM Jr,Gores GJ,Pfenning MA

更新日期：2013-12-01 00:00:00

abstract：:Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous system, and induced pluripotent stem cells (iPSCs) are envisioned to b...

journal_title：Stem cells and development

authors： Umebayashi D,Coles B,van der Kooy D

更新日期：2016-05-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:In spina bifida, the neural tube fails to close during the embryonic period. Exposure of the neural tube to the amniotic fluid during pregnancy causes additional neural damage. Intrauterine tissue engineering using a biomaterial seeded with stem cells might prevent this additional damage. For this purpose, autologous ...

journal_title：Stem cells and development

authors： Hosper NA,Bank RA,van den Berg PP

更新日期：2014-03-01 00:00:00

abstract：:Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodo...

journal_title：Stem cells and development

authors： Tomokiyo A,Wada N,Maeda H

更新日期：2019-08-01 00:00:00

abstract：:Members of helix-loop-helix (HLH) protein family of Id (inhibitor of differentiation) dimerize with bHLH transcription factors and function as negative regulators of differentiation during development. Most of inhibitory roles of Id proteins have been demonstrated in non-neural tissues, and their roles in the developi...

journal_title：Stem cells and development

authors： Jung S,Park RH,Kim S,Jeon YJ,Ham DS,Jung MY,Kim SS,Lee YD,Park CH,Suh-Kim H

更新日期：2010-06-01 00:00:00

abstract：:We recently reported the isolation and characterization of a population of pancreatic progenitor cells (PPCs) from early trimester human fetal pancreata. The PPCs, being the forerunners of adult pancreatic cell lineages, were amenable to growth and differentiation into insulin-secreting islet-like cell clusters (ICCs)...

journal_title：Stem cells and development

authors： Leung KK,Suen PM,Lau TK,Ko WH,Yao KM,Leung PS

更新日期：2009-09-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. In this study, we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from random positioning machine (...

journal_title：Stem cells and development

authors： Ratushnyy A,Ezdakova M,Yakubets D,Buravkova L

更新日期：2018-06-15 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Cell-based gene therapy holds a great promise for the treatment of human malignancy. Among different cells, mesenchymal stem cells (MSCs) are emerging as valuable anti-cancer agents that have the potential to be used to treat a number of different cancer types. They have inherent migratory properties, which allow them...

journal_title：Stem cells and development

authors： Nowakowski A,Drela K,Rozycka J,Janowski M,Lukomska B

更新日期：2016-10-01 00:00:00

abstract：:Dental follicle stem cells (DFSCs), which are the stem cells present in the dental follicle tissue of the tooth germ and are derived from the neural crest, are direct precursor cells of periodontal tissues and can form the periodontal ligament, cementum, and alveolar bone proper in the late stage of tooth development....

journal_title：Stem cells and development

authors： Zhang J,Ding H,Liu X,Sheng Y,Liu X,Jiang C

更新日期：2019-08-01 00:00:00