Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells.

abstract：:Regenerative therapy of the salivary gland (SG) is a promising therapeutic approach for irreversible hyposalivation in patients with head and neck cancer treated by radiotherapy. However, little is known about the molecular regulators of stem/progenitor cell activity and regenerative processes in the SG. Wnt/β-catenin...

journal_title：Stem cells and development

authors： Hai B,Yang Z,Millar SE,Choi YS,Taketo MM,Nagy A,Liu F

更新日期：2010-11-01 00:00:00

abstract：:Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is an extracellular matrix...

journal_title：Stem cells and development

authors： Ghazalli N,Mahdavi A,Feng T,Jin L,Kozlowski MT,Hsu J,Riggs AD,Tirrell DA,Ku HT

更新日期：2015-09-01 00:00:00

abstract：:Inducing a stable and predictable program of neural cell fate in pluripotent cells in vitro is an important goal for utilizing these cells for modeling human disease mechanisms. However, the extent to which in vitro neural specification recapitulates in vivo neural specification remains to be fully established. We pre...

journal_title：Stem cells and development

authors： Dang LT,Wong L,Tropepe V

更新日期：2012-10-10 00:00:00

abstract：:Traditionally, undifferentiated pluripotent human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) have been expanded as monolayer colonies in adhesion culture, both in the presence or absence of feeder cells. However, the use of pluripotent stem cells poses the need to scale-up current culture methods....

journal_title：Stem cells and development

authors： Larijani MR,Seifinejad A,Pournasr B,Hajihoseini V,Hassani SN,Totonchi M,Yousefi M,Shamsi F,Salekdeh GH,Baharvand H

更新日期：2011-11-01 00:00:00

abstract：:Small-molecule inhibitors of glycogen synthase kinase 3β (GSK3β) have demonstrated strong anti-leukemia effects in preclinical studies. Here, we investigated the effect of GSK3β inhibitor 6-Bromoindirubin-3-oxime (BIO) previously shown to inhibit leukemia cell growth in vitro and of animal models on hematopoietic rege...

journal_title：Stem cells and development

authors： Shen S,Xu N,Klamer G,Ko KH,Khoo M,Ma D,Moore J,O'Brien TA,Dolnikov A

更新日期：2015-03-15 00:00:00

abstract：:Multipotent stem/progenitor cells from bone marrow stroma (mesenchymal stromal cells or MSCs) were previously shown to enhance proliferation and differentiation of neural stem cells (NSCs) in vivo, but the molecular basis of the effect was not defined. Here coculturing human MSCs (hMSCs) with rat NSCs (rNSCs) was foun...

journal_title：Stem cells and development

authors： Robinson AP,Foraker JE,Ylostalo J,Prockop DJ

更新日期：2011-02-01 00:00:00

abstract：:Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, which is marked by decreased expression of Nanog and increased expression of neural stem cell marker N...

journal_title：Stem cells and development

authors： Tan Y,Xie Z,Ding M,Wang Z,Yu Q,Meng L,Zhu H,Huang X,Yu L,Meng X,Chen Y

更新日期：2010-09-01 00:00:00

abstract：:The field of regenerative medicine has increasingly recognized the importance to be inspired by developmental processes to identify signaling pathways crucial for 3D organogenesis and tissue regeneration. Here, we aimed at recapitulating the first events occurring during limb development (ie, cell condensation and exp...

journal_title：Stem cells and development

authors： Centola M,Tonnarelli B,Schären S,Glaser N,Barbero A,Martin I

更新日期：2013-11-01 00:00:00

abstract：:Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long culture history. Several mechanisms were described to account for this capability. Since several of the described mechanis...

journal_title：Stem cells and development

authors： van den Berk LC,Jansen BJ,Snowden S,Siebers-Vermeulen KG,Gilissen C,Kögler G,Figdor CG,Wheelock CE,Torensma R

更新日期：2014-07-15 00:00:00

abstract：:Heterotopic ossification (HO) is a common and debilitating complication of burns, traumatic brain injuries, and musculoskeletal trauma and surgery. Although the exact mechanism of ectopic bone formation is unknown, mesenchymal stem cells (MSCs) capable of osteogenic differentiation are known to play an essential role....

journal_title：Stem cells and development

authors： Peterson JR,Eboda ON,Brownley RC,Cilwa KE,Pratt LE,De La Rosa S,Agarwal S,Buchman SR,Cederna PS,Morris MD,Wang SC,Levi B

更新日期：2015-01-15 00:00:00

abstract：:The clinical use of stem cells in cell-based therapeutics for degenerative diseases requires development of criteria for defining normal stem cells to ensure safe transplantation. Currently, identification of abnormal from normal stem cells is based on extensive ex vivo and in vivo testing. Raman microscopy is a label...

journal_title：Stem cells and development

authors： Harkness L,Novikov SM,Beermann J,Bozhevolnyi SI,Kassem M

更新日期：2012-08-10 00:00:00

abstract：:Mesenchymal stem cells (MSC) possess a range of immunomodulatory properties which they exert through soluble mediators and through direct cell-cell contact. Due to these immune regulatory properties, the safety and clinical efficacy of MSC treatment has been tested in a number of autoimmune disorders. In this review w...

journal_title：Stem cells and development

authors： Munir H,McGettrick HM

更新日期：2015-09-15 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...

journal_title：Stem cells and development

authors： Helm A,Arrizabalaga O,Pignalosa D,Schroeder IS,Durante M,Ritter S

更新日期：2016-01-15 00:00:00

abstract：:Stem cell factor (SCF) stimulation of the receptor tyrosine kinase c-kit has effects on the proliferation, differentiation, and apoptotic regulation of hematopoietic progenitor cell populations. Rat bone marrow myelomonocytic stem cells (MSC) isolated in vitro by wheat germ agglutinin culture exclusively undergo self-...

journal_title：Stem cells and development

authors： Lucas T,Pratscher B,Fink D,Wolschek M,Samorapoompichit P,Schöfer C,Pehamberger H,Müller M,Sorensen P,Jansen B

更新日期：2005-10-01 00:00:00

abstract：:Pericytes play a crucial role in angiogenesis and vascular maintenance. They can be readily identified in vivo and isolated as CD146(+)CD34(-) cells from various tissues. Whether these and other markers reliably identify pericytes in vitro is unclear. CD146(+)CD34(-) selected cells exhibit multilineage potential. Thus...

journal_title：Stem cells and development

authors： Blocki A,Wang Y,Koch M,Peh P,Beyer S,Law P,Hui J,Raghunath M

更新日期：2013-09-01 00:00:00

abstract：:Oligodendrogenesis encompasses lineage specification of neural progenitor cells (NPCs) and differentiation into oligodendrocytes that ultimately culminates in the myelination of central nervous system axons. Each individual process must be tightly regulated by extracellular and cell-intrinsic mechanisms, whose identit...

journal_title：Stem cells and development

authors： Steffenhagen C,Dechant FX,Oberbauer E,Furtner T,Weidner N,Küry P,Aigner L,Rivera FJ

更新日期：2012-07-20 00:00:00

abstract：:Small molecules (SM) can greatly enhance the efficiency of induced pluripotent stem (iPS) cell generation, but the mechanisms by which they act have not been fully explored. We show here that an SM cocktail (NaB, PD03259, and SB431542) significantly promotes iPS cell generation from human fibroblasts, and NaB is more ...

journal_title：Stem cells and development

authors： Zhang Z,Wu WS

更新日期：2013-08-15 00:00:00

abstract：:Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites o...

journal_title：Stem cells and development

authors： Hochheuser C,Windt LJ,Kunze NY,de Vos DL,Tytgat GAM,Voermans C,Timmerman I

更新日期：2021-01-15 00:00:00

abstract：:Stem cell-based therapy is a promising treatment for neurodegenerative diseases. In our laboratory, a novel protocol has been developed to induce bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factors- secreting cells (NTF-SC), thus combining stem cell-based therapy with the NTF-based neuroprotecti...

journal_title：Stem cells and development

authors： Sadan O,Bahat-Stromza M,Barhum Y,Levy YS,Pisnevsky A,Peretz H,Ilan AB,Bulvik S,Shemesh N,Krepel D,Cohen Y,Melamed E,Offen D

更新日期：2009-10-01 00:00:00

abstract：:Extracellular stresses influence transcription factor (TF) expression and therefore lineage identity in the peri-implantation mouse embryo and its stem cells. This potentially affects pregnancy outcome. To understand the effects of stress signaling during this critical period of pregnancy, we exposed cultured murine e...

journal_title：Stem cells and development

authors： Slater JA,Zhou S,Puscheck EE,Rappolee DA

更新日期：2014-12-15 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) show great potential for clinical and experimental use due to their capacity to self-renew and differentiate into multiple mesenchymal lineages. However, disadvantages of primary cultures of hMSCs are the limited in vitro lifespan, and the variable properties of cells from diffe...

journal_title：Stem cells and development

authors： Skårn M,Noordhuis P,Wang MY,Veuger M,Kresse SH,Egeland EV,Micci F,Namløs HM,Håkelien AM,Olafsrud SM,Lorenz S,Haraldsen G,Kvalheim G,Meza-Zepeda LA,Myklebost O

更新日期：2014-10-01 00:00:00

abstract：:In this study, we isolated and characterized spontaneously differentiated human embryonic stem cells (SD-hESCs) found in hESC colonies in comparison to the morphologically premature ESCs in the colonies to investigate the potential role of SD-hESCs in embryogenesis. SD-hESCs were distinguished from undifferentiated hE...

journal_title：Stem cells and development

authors： Lee JH,Hong KS,Mantel C,Broxmeyer HE,Lee MR,Kim KS

更新日期：2013-10-15 00:00:00

abstract：:Amniotic fluid stem cells (AFSs) are interesting mesenchymal stem cells (MSCs) that are characterized by their great potential for cell proliferation and differentiation compared with other types of MSCs identified to date. However, MSCs in prolonged culture have been found to exhibit defects in genetic stability and ...

journal_title：Stem cells and development

authors： Phermthai T,Suksompong S,Tirawanchai N,Issaragrisil S,Julavijitphong S,Wichitwiengrat S,Silpsorn D,Pokathikorn P

更新日期：2013-05-01 00:00:00

abstract：:The capability to form all cell types of the body is a unique feature of stem cells. However, many questions remain concerning the mechanisms regulating differentiation potential. The derivation of spermatogonial cell lines (SGs) from mouse and human, which can differentiate across germ-layer borders, suggested male g...

journal_title：Stem cells and development

authors： Thoma EC,Wagner TU,Weber IP,Herpin A,Fischer A,Schartl M

更新日期：2011-08-01 00:00:00

abstract：:How hematopoietic stem cells (HSCs) maintain the balance of self-renewal and differentiation could be partially ascribed to asymmetric and symmetric division patterns. However, a simple and effective method to detect stem cell division patterns is lacking. In this study, we introduce a strategy to describe stem cells ...

journal_title：Stem cells and development

authors： Yang WZ,Yu WY,Chen T,Wang XF,Dong F,Xie ME,Gong YM,Liang HY,Fu WC

更新日期：2019-07-15 00:00:00

abstract：:Bone marrow-mesenchymal stem cells (BM-MSC) ameliorate renal dysfunction and repair tubular damage of acute kidney injury by locally releasing growth factors, including the insulin-like growth factor-1 (IGF-1). The restricted homing of BM-MSC at the site of injury led us to investigate a possible gene-based communicat...

journal_title：Stem cells and development

authors： Tomasoni S,Longaretti L,Rota C,Morigi M,Conti S,Gotti E,Capelli C,Introna M,Remuzzi G,Benigni A

更新日期：2013-03-01 00:00:00

abstract：:Members of helix-loop-helix (HLH) protein family of Id (inhibitor of differentiation) dimerize with bHLH transcription factors and function as negative regulators of differentiation during development. Most of inhibitory roles of Id proteins have been demonstrated in non-neural tissues, and their roles in the developi...

journal_title：Stem cells and development

authors： Jung S,Park RH,Kim S,Jeon YJ,Ham DS,Jung MY,Kim SS,Lee YD,Park CH,Suh-Kim H

更新日期：2010-06-01 00:00:00

abstract：:Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by defined factors. However, substantial cell numbers subjected to iPSC induction stray from the main reprogramming route and are immortalized as partial iPSCs. These partial iPSCs can become genuine iPSCs by exposure to the ground state condi...

journal_title：Stem cells and development

authors： Kamon M,Katano M,Hiraki-Kamon K,Hishida T,Nakachi Y,Mizuno Y,Okazaki Y,Suzuki A,Hirasaki M,Ueda A,Nishimoto M,Kato H,Okuda A

更新日期：2014-09-15 00:00:00

abstract：:Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors inf...

journal_title：Stem cells and development

authors： Aked J,Delavaran H,Lindvall O,Norrving B,Kokaia Z,Lindgren A

更新日期：2017-04-15 00:00:00