Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells.

abstract：:Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC...

journal_title：Stem cells and development

authors： Knorr DA,Bock A,Brentjens RJ,Kaufman DS

更新日期：2013-07-01 00:00:00

abstract：:Conditioned media (CM) of transformed cells, such as the human lung-derived A549 cells, is a useful tool for directing differentiation of embryonic stem cells (ESCs). Previous work indicates that A549-CM induced pulmonary differentiation of mouse ESCs (mESCs). In this study, we compared the effects of A549-CM treatmen...

journal_title：Stem cells and development

authors： Lecht S,Gerstenhaber JA,Stabler CT,Pimton P,Karamil S,Marcinkiewicz C,Schulman ES,Lelkes PI

更新日期：2014-08-15 00:00:00

abstract：:The success rate of human embryonic stem cell (hESC) derivation depends on both culture conditions and embryo quality and is routinely determined by morphological criteria. However, high incidence of chromosomal abnormality even in high-grade cleavage embryos from in vitro fertilization (IVF) patients suggests that th...

journal_title：Stem cells and development

authors： Ilic D,Caceres E,Lu S,Julian P,Foulk R,Krtolica A

更新日期：2010-01-01 00:00:00

abstract：:Spiral ganglion neurons (SGNs) are usually damaged in sensorineural hearing loss. SGN-derived neural stem cells (NSCs) have been identified and proposed to differentiate into neurons to replace damaged SGNs. However, it remains obscure whether SGN-NSC-derived neurons (ScNs) are electrophysiologically functional and po...

journal_title：Stem cells and development

authors： Li X,Aleardi A,Wang J,Zhou Y,Andrade R,Hu Z

更新日期：2016-05-15 00:00:00

abstract：:The increasing use of mesenchymal stromal cells (MSC) in clinical cellular therapy requires a safe and controlled production process compliant with Good Manufacturing Practice guidelines. Pooled blood group AB human serum (HS) has been used to replace fetal bovine serum (FBS), critically rated by the regulatory agenci...

journal_title：Stem cells and development

authors： Dreher L,Elvers-Hornung S,Brinkmann I,Huck V,Henschler R,Gloe T,Klüter H,Bieback K

更新日期：2013-03-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have shown potential to improve treatment of renal failure. The prohealing functions of MSCs have been found to be enhanced by treatment with the lipid mediator, 14S,21R-dihydroxy-docosa4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (14S,21R-diHDHA). In this article, using a murine mode...

journal_title：Stem cells and development

authors： Tian H,Lu Y,Shah SP,Wang Q,Hong S

更新日期：2012-05-01 00:00:00

abstract：:Heterotopic ossification (HO) is a common and debilitating complication of burns, traumatic brain injuries, and musculoskeletal trauma and surgery. Although the exact mechanism of ectopic bone formation is unknown, mesenchymal stem cells (MSCs) capable of osteogenic differentiation are known to play an essential role....

journal_title：Stem cells and development

authors： Peterson JR,Eboda ON,Brownley RC,Cilwa KE,Pratt LE,De La Rosa S,Agarwal S,Buchman SR,Cederna PS,Morris MD,Wang SC,Levi B

更新日期：2015-01-15 00:00:00

abstract：:Recent studies have revealed that mesenchymal stem cells (MSCs) have a great potential in therapeutic applications. The low efficiency of MSC recruitment and homing to sites of diseased organ tissue, however, remains a major hurdle in their application for treatment of diseases. Stress is commonly associated with vari...

journal_title：Stem cells and development

authors： Zhang S,Lv C,Yang X,Han Z,Zhang S,Zhang J,Zong C,Gao L,Li L,Zhao Q,Li R,Yang Y,Yu F,Li X,Zhang P,Wei L

更新日期：2015-03-01 00:00:00

abstract：:Extracellular stresses influence transcription factor (TF) expression and therefore lineage identity in the peri-implantation mouse embryo and its stem cells. This potentially affects pregnancy outcome. To understand the effects of stress signaling during this critical period of pregnancy, we exposed cultured murine e...

journal_title：Stem cells and development

authors： Slater JA,Zhou S,Puscheck EE,Rappolee DA

更新日期：2014-12-15 00:00:00

abstract：:Mesenchymal stem cells (MSC) possess a range of immunomodulatory properties which they exert through soluble mediators and through direct cell-cell contact. Due to these immune regulatory properties, the safety and clinical efficacy of MSC treatment has been tested in a number of autoimmune disorders. In this review w...

journal_title：Stem cells and development

authors： Munir H,McGettrick HM

更新日期：2015-09-15 00:00:00

abstract：:We describe a method of generating an enriched population of NCAM-positive cells from a human teratocarcinoma cell line (NTera2/D1) and their differentiation into midbrain dopaminergic neurons in the absence of the caudalizing factor retinoic acid (RA). NTera2 cells were induced to form embryoid bodies and then to gen...

journal_title：Stem cells and development

authors： Ravindran G,Rao HS

更新日期：2006-08-01 00:00:00

abstract：:Here, we describe a focused microarray for screening rat embryonic stem cells (ESCs) and provide validation data that this array can distinguish undifferentiated rat ESCs from rat trophoblast stem (TS) cells, rat extraembryonic endoderm cells, mouse embryonic fibroblast feeder cells, and differentiated rat ESCs. Using...

journal_title：Stem cells and development

authors： Hong J,He H,Bui P,Ryba-White B,Rumi MA,Soares MJ,Dutta D,Paul S,Kawamata M,Ochiya T,Ying QL,Rajanahalli P,Weiss ML

更新日期：2013-02-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) self-renew indefinitely as highly organized pluripotent colonies. Unlike mouse pluripotent stem cell colonies, human colonies form a uniform, flat, epithelium-like monolayer. Interestingly, it has been reported that colony morphology is closely correlated with the maintenance of plur...

journal_title：Stem cells and development

authors： Kim JM,Moon SH,Park SJ,Lee HY,Hong KS,Seo J,Bae YS,Chung HM

更新日期：2013-01-15 00:00:00

abstract：:The major reservoir of human multipotent mesenchymal stem/stromal cells (MSCs) is the bone marrow (BM) with the capability to control hematopoietic stem cell development. The regenerative potential of MSCs is associated with enhanced endogenous repair and healing mechanisms that modulate inflammatory responses. Our pr...

journal_title：Stem cells and development

authors： Bacskai I,Mázló A,Kis-Tóth K,Szabó A,Panyi G,Sarkadi B,Apáti Á,Rajnavölgyi É

更新日期：2015-08-01 00:00:00

abstract：:To understand which growth factors/cytokines can affect migration of mesenchymal stem cells (MSCs) to injured tissues, we compared the effects of many (26) growth factors/cytokines on the migration activity of rabbit and human MSCs using a microchemotaxis chamber. Among them, platelet-derived growth factor (PDGF)-BB, ...

journal_title：Stem cells and development

authors： Ozaki Y,Nishimura M,Sekiya K,Suehiro F,Kanawa M,Nikawa H,Hamada T,Kato Y

更新日期：2007-02-01 00:00:00

abstract：:Stem cell therapies show great medical promise, but few new products have made it into the marketplace. The translation of stem and other cell therapies faces not only challenges associated with research and development, but also the challenges of investment funding and regulatory approval. Regulators and investors al...

journal_title：Stem cells and development

authors： Plant AL,Parker GC

更新日期：2013-09-15 00:00:00

abstract：:Over the past 20 months, reports claiming the generation of induced pluripotent stem (iPS) cells with characteristics identical to those of embryonic stem (ES) cells from nonembryonic tissue have captured great attention in both the scientific community and the general public. In the light of the continuing controvers...

journal_title：Stem cells and development

authors： Liu SV

更新日期：2008-06-01 00:00:00

abstract：:Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long culture history. Several mechanisms were described to account for this capability. Since several of the described mechanis...

journal_title：Stem cells and development

authors： van den Berk LC,Jansen BJ,Snowden S,Siebers-Vermeulen KG,Gilissen C,Kögler G,Figdor CG,Wheelock CE,Torensma R

更新日期：2014-07-15 00:00:00

abstract：:Human embryonic stem cells (hESCs) exhibiting skewed X chromosome inactivation (XCI) have been reported. The copy number variations (CNVs), loss of heterozygosity (LOH), or single-nucleotide variant (SNV) events in those epigenetically distinct cells remain unknown, and whether such genetic abnormalities will influenc...

journal_title：Stem cells and development

authors： Liu WQ,Li JL,Wang J,He WY,Va L,Sheng XM,Wu BL,Sun XF

更新日期：2015-08-01 00:00:00

abstract：:Non-tumorous liver tissue removed during surgery to resect hepatocellular carcinoma (HCC) is potentially a useful source of material from which cells, particularly liver progenitor/stem cells (LPCs), can be isolated to establish cell lines. The purpose of this study was to evaluate the applicability of the "plate-and-...

journal_title：Stem cells and development

authors： Zhang A,London R,Schulz FM,Giguère-Simmonds PW,Delriviere L,Chandraratana H,Hardy K,Zheng S,Olynyk JK,Yeoh G

更新日期：2010-08-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have the capacity to form all the tissues in the body and hence, directed differentiation of ESCs along specific lineages represents a means to generate therapeutically useful cell types. It has been postulated that, during in vitro differentiation, ES cells sequentially pass through simila...

journal_title：Stem cells and development

authors： Mossman AK,Sourris K,Ng E,Stanley EG,Elefanty AG

更新日期：2005-12-01 00:00:00

abstract：:Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the developing fetus, and may represent a novel source of stem cells for cell therapy. In this study, we examined the paracrine factors released by human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) and their ability to...

journal_title：Stem cells and development

authors： Yoon BS,Moon JH,Jun EK,Kim J,Maeng I,Kim JS,Lee JH,Baik CS,Kim A,Cho KS,Lee JH,Lee HH,Whang KY,You S

更新日期：2010-06-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...

journal_title：Stem cells and development

authors： Wu JH,Wang HJ,Tan YZ,Li ZH

更新日期：2012-05-20 00:00:00

abstract：:The corneal endothelium is believed to be developmentally originated from the periocular mesenchyme via the neural crest. Human corneal endothelial progenitor cells (HCEPs) have been investigated because of their potential availability for the tissue regenerative medicine. However, the existence and the properties of ...

journal_title：Stem cells and development

authors： Hara S,Hayashi R,Soma T,Kageyama T,Duncan T,Tsujikawa M,Nishida K

更新日期：2014-09-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are somatic cells that have been reprogrammed to a pluripotent state via introduction of defined transcription factors. iPSCs are a valuable resource for regenerative medicine, but whether iPSCs are identical to embryonic stem cells (ESCs) remains unclear. In this study, we perfo...

journal_title：Stem cells and development

authors： Kim SY,Kim MJ,Jung H,Kim WK,Kwon SO,Son MJ,Jang IS,Choi JS,Park SG,Park BC,Han YM,Lee SC,Cho YS,Bae KH

更新日期：2012-05-20 00:00:00

abstract：:After intra-articular injection, synovium-derived mesenchymal stem cells (SMSCs) can adhere to damaged cartilage (a process called homing) and then repair the cartilage defect. Nonetheless, the main obstacle of the current method is the insufficient homing ratio of SMSCs, which fails to meet the requirements for carti...

journal_title：Stem cells and development

authors： Liang C,Huang J,Luo P,Wang Z,He J,Wu S,Peng C,Cao X

更新日期：2020-04-01 00:00:00

abstract：:Stem cell-based therapies have demonstrated great potential for the treatment of cardiac diseases, for example, myocardial infarction; however, low cell viability, low retention/engraftment, and uncontrollable in vivo differentiation after transplantation are still major limitations, which lead to low therapeutic effi...

journal_title：Stem cells and development

authors： Ledford BT,Simmons J,Chen M,Fan H,Barron C,Liu Z,Van Dyke M,He JQ

更新日期：2017-06-15 00:00:00

abstract：:Tendons and ligaments (T/L) are dense connective tissues of mesodermal origin. During embryonic development, the tendon-specific cells descend from a sub-set of mesenchymal progenitors condensed in the syndetome, a dorsolateral domain of the sclerotome. These cells are defined by the expression of the transcription fa...

journal_title：Stem cells and development

authors： Alberton P,Popov C,Prägert M,Kohler J,Shukunami C,Schieker M,Docheva D

更新日期：2012-04-10 00:00:00

abstract：:Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites o...

journal_title：Stem cells and development

authors： Hochheuser C,Windt LJ,Kunze NY,de Vos DL,Tytgat GAM,Voermans C,Timmerman I

更新日期：2021-01-15 00:00:00