Platelet-Derived Microparticles Mediate the Intra-Articular Homing of Mesenchymal Stem Cells in Early-Stage Cartilage Lesions.

abstract：:White matter damage persists in hypoxic-ischemic newborns even when treated with hypothermia. We have previously shown that intraventricular delivery of human glial progenitors (GPs) at the neonatal stage is capable of replacing abnormal host glia and rescuing the lifespan of dysmyelinated mice. However, such transpla...

journal_title：Stem cells and development

authors： Srivastava RK,Jablonska A,Chu C,Gregg L,Bulte JWM,Koehler RC,Walczak P,Janowski M

更新日期：2019-04-15 00:00:00

abstract：:The peritoneum mesothelium lines body cavities and has the same origin as ovarian surface epithelium with probable existence of peritoneum mesenchymal stem cells (PMSCs). In the present research, PMSCs were isolated from peritoneum and differentiated into ovarian cell-like cells using human follicular fluid (HFF) and ...

journal_title：Stem cells and development

authors： Mirzaeian L,Eftekhari-Yazdi P,Esfandiari F,Eivazkhani F,Rezazadeh Valojerdi M,Moini A,Fathi R

更新日期：2019-04-15 00:00:00

abstract：:Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence r...

journal_title：Stem cells and development

authors： Raad S,David A,Que J,Faure C

更新日期：2020-08-01 00:00:00

abstract：:Cardiac stem/progenitors are being used in the clinic to treat patients with a range of cardiac pathologies. However, improvements in heart function following treatment have been reported to be variable, with some showing no response. This discrepancy in response remains unresolved. Mesenchymal stem cells (MSCs) have ...

journal_title：Stem cells and development

authors： Oldershaw R,Owens WA,Sutherland R,Linney M,Liddle R,Magana L,Lash GE,Gill JH,Richardson G,Meeson A

更新日期：2019-05-01 00:00:00

abstract：:The hedgehog (Hh) signaling pathway plays fundamental roles during embryonic development and tumorigenesis. Previously, we have shown that ablation of the tumor suppressor and negative regulator, Suppressor of fused (Sufu), within this pathway causes embryonic lethality around E9.5 in the mouse. In this study, we exam...

journal_title：Stem cells and development

authors： Hoelzl MA,Heby-Henricson K,Bilousova G,Rozell B,Kuiper RV,Kasper M,Toftgård R,Teglund S

更新日期：2015-11-01 00:00:00

abstract：:Embryonic stem cell (ESC) research gave rise to the possibility that stem cell therapy could be used in the treatment of incurable diseases such as neurodegenerative disorders. However, problems related to the tumorigenicity of undifferentiated ESCs must be resolved before such cells can be used in the application of ...

journal_title：Stem cells and development

authors： Park KD,Seong SK,Park YM,Choi Y,Park JH,Lee SH,Baek DH,Kang JW,Choi KS,Park SN,Kim DS,Kim SH,Kim HS

更新日期：2011-01-01 00:00:00

abstract：:Protein tyrosine phosphatases have been recognized as critical components of multiple signaling regulators of fundamental cellular processes, including differentiation, cell death, and migration. In this study, we show that dual specificity phosphatase 4 (DUSP4) is crucial for neuronal differentiation and functions in...

journal_title：Stem cells and development

authors： Kim SY,Han YM,Oh M,Kim WK,Oh KJ,Lee SC,Bae KH,Han BS

更新日期：2015-03-15 00:00:00

abstract：:Fertility clinics worldwide routinely produce a large volume of 'waste' follicular aspirate, which is potentially an abundant source of immature ovarian follicles. Current attempts to cultivate these further in vitro to yield viable mature oocytes for fertility treatment have not yet achieved much success. Instead, re...

journal_title：Stem cells and development

authors： Heng BC,Cao T,Bested SM,Tong GQ,Ng SC

更新日期：2005-02-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament (OPLL) is characterized by ectopic OPLL. To date, the specific molecular pathogenesis of OPLL has not been clearly elucidated. In this study, bone marrow-derived mesenchymal stem cells obtained from healthy donors (HD-MSCs) and patients with OPLL (OPLL-MSCs) were cul...

journal_title：Stem cells and development

authors： Cai Z,Wu B,Ye G,Liu W,Chen K,Wang P,Xie Z,Li J,Zheng G,Yu W,Su Z,Lin J,Wu Y,Shen H

更新日期：2020-12-01 00:00:00

abstract：:PU.1 is a versatile hematopoietic cell-specific ETS-family transcriptional regulator required for the development of both the inborn and the adaptive immunity, owing to its potential ability to regulate the expression of multiple genes specific for different lineages during normal hematopoiesis. It functions in a cell...

journal_title：Stem cells and development

authors： Gangenahalli GU,Gupta P,Saluja D,Verma YK,Kishore V,Chandra R,Sharma RK,Ravindranath T

更新日期：2005-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. In this study, we sh...

journal_title：Stem cells and development

authors： Liu X,Ren S,Ge C,Cheng K,Li X,Zhao RC

更新日期：2018-04-15 00:00:00

abstract：:To better understand the basis of variation in cellular reprogramming, we performed experiments with two primary objectives: first, to determine the degree of difference, if any, in reprogramming efficiency among cells lines of a similar type after accounting for technical variables, and second, to compare the efficie...

journal_title：Stem cells and development

authors： Alicea B,Murthy S,Keaton SA,Cobbett P,Cibelli JB,Suhr ST

更新日期：2013-10-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. In this study, we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from random positioning machine (...

journal_title：Stem cells and development

authors： Ratushnyy A,Ezdakova M,Yakubets D,Buravkova L

更新日期：2018-06-15 00:00:00

abstract：:Progenitor expansion during development is a highly regulated process dictating the final organ size, while expansion of specific progenitor populators can adjust the final cellular composition of the organ. Understanding factors involved in these pathways is required to develop cell-based therapies such as β-cell tra...

journal_title：Stem cells and development

authors： Belo J,Krishnamurthy M,Oakie A,Wang R

更新日期：2013-11-15 00:00:00

abstract：:Recent studies have revealed that mesenchymal stem cells (MSCs) have a great potential in therapeutic applications. The low efficiency of MSC recruitment and homing to sites of diseased organ tissue, however, remains a major hurdle in their application for treatment of diseases. Stress is commonly associated with vari...

journal_title：Stem cells and development

authors： Zhang S,Lv C,Yang X,Han Z,Zhang S,Zhang J,Zong C,Gao L,Li L,Zhao Q,Li R,Yang Y,Yu F,Li X,Zhang P,Wei L

更新日期：2015-03-01 00:00:00

abstract：:Dental follicle stem cells (DFSCs), which are the stem cells present in the dental follicle tissue of the tooth germ and are derived from the neural crest, are direct precursor cells of periodontal tissues and can form the periodontal ligament, cementum, and alveolar bone proper in the late stage of tooth development....

journal_title：Stem cells and development

authors： Zhang J,Ding H,Liu X,Sheng Y,Liu X,Jiang C

更新日期：2019-08-01 00:00:00

abstract：:The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...

journal_title：Stem cells and development

authors： Rüster B,Grace B,Seitz O,Seifried E,Henschler R

更新日期：2005-04-01 00:00:00

abstract：:Administration of human bone marrow-derived mesenchymal stem cells (BM-MSCs) significantly alleviates allergic airway inflammation. There are no studies that refer to the role of microRNAs (miRNAs) after the BM-MSCs treatment in airway allergic inflammation. We induced a mouse model of asthma and performed the transpl...

journal_title：Stem cells and development

authors： Tang GN,Li CL,Yao Y,Xu ZB,Deng MX,Wang SY,Sun YQ,Shi JB,Fu QL

更新日期：2016-06-15 00:00:00

abstract：:We have isolated a novel progenitor cell population from adult rat pancreatic ducts, termed pancreatic-derived progenitor cells (PDPCs). Here, we report the in vitro culture, selection, and characterization of Thy1.1-positive and Thy1.1-negative PDPC subpopulations. These cells exhibit bipotentiality for differentiati...

journal_title：Stem cells and development

authors： Stevenson KS,McGlynn L,Hodge M,McLinden H,George WD,Davies RW,Shiels PG

更新日期：2009-12-01 00:00:00

abstract：:Traditionally, undifferentiated pluripotent human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) have been expanded as monolayer colonies in adhesion culture, both in the presence or absence of feeder cells. However, the use of pluripotent stem cells poses the need to scale-up current culture methods....

journal_title：Stem cells and development

authors： Larijani MR,Seifinejad A,Pournasr B,Hajihoseini V,Hassani SN,Totonchi M,Yousefi M,Shamsi F,Salekdeh GH,Baharvand H

更新日期：2011-11-01 00:00:00

abstract：:Death ligands and their tumor necrosis factor receptor (TNFR) family receptors are the best-characterized and most efficient inducers of apoptotic signaling in somatic cells. In this study, we analyzed whether these prototypic activators of apoptosis are also expressed and able to be activated in human pluripotent ste...

journal_title：Stem cells and development

authors： Vinarsky V,Krivanek J,Rankel L,Nahacka Z,Barta T,Jaros J,Andera L,Hampl A

更新日期：2013-11-15 00:00:00

abstract：:Osteophytes are a distinct feature of osteoarthritis (OA). Their formation may be related to pluripotential cells in the periosteum responding to stimulus during OA. This study aimed to isolate stem cells from osteophyte tissues and to characterize their phenotype, proliferation, and differentiation potential, as well...

journal_title：Stem cells and development

authors： Singh S,Jones BJ,Crawford R,Xiao Y

更新日期：2008-04-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. However, it is essential to unde...

journal_title：Stem cells and development

authors： Tatebayashi K,Tanaka Y,Nakano-Doi A,Sakuma R,Kamachi S,Shirakawa M,Uchida K,Kageyama H,Takagi T,Yoshimura S,Matsuyama T,Nakagomi T

更新日期：2017-06-01 00:00:00

abstract：:Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic printing. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using chromatin immunoprecipitation (ChIP)-polymerase chain reaction and ChI...

journal_title：Stem cells and development

authors： Leschik J,Caron L,Yang H,Cowan C,Pucéat M

更新日期：2015-02-01 00:00:00

abstract：:The clinical use of stem cells in cell-based therapeutics for degenerative diseases requires development of criteria for defining normal stem cells to ensure safe transplantation. Currently, identification of abnormal from normal stem cells is based on extensive ex vivo and in vivo testing. Raman microscopy is a label...

journal_title：Stem cells and development

authors： Harkness L,Novikov SM,Beermann J,Bozhevolnyi SI,Kassem M

更新日期：2012-08-10 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are more and more frequently used to treat orthopedic injuries in horses. However, these cells are limited in their expandability and differentiation capacity. Recently, the first equine-induced pluripotent stem cell (iPSC) lines were reported by us [ 1 ]. In vitro differen...

journal_title：Stem cells and development

authors： Lepage SI,Nagy K,Sung HK,Kandel RA,Nagy A,Koch TG

更新日期：2016-01-01 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with significant morbidity and mortality, and it often leads to poor clinical outcome. Although great efforts have been made toward animal and clinical studies, optimal therapy of SAH remains a challenge for scientists and clinicians. Increasing evidence su...

journal_title：Stem cells and development

authors： Song Z,Zhang JH

更新日期：2020-02-15 00:00:00

abstract：:Electrical stimulation (ES) of cells has been shown to induce a variety of responses, such as cytoskeleton rearrangements, migration, proliferation, and differentiation. In this study, we have investigated whether monophasic and biphasic pulsed ES could exert any effect on the proliferation and differentiation of huma...

journal_title：Stem cells and development

authors： Pietronave S,Zamperone A,Oltolina F,Colangelo D,Follenzi A,Novelli E,Diena M,Pavesi A,Consolo F,Fiore GB,Soncini M,Prat M

更新日期：2014-04-15 00:00:00