Abstract:
:Progenitor expansion during development is a highly regulated process dictating the final organ size, while expansion of specific progenitor populators can adjust the final cellular composition of the organ. Understanding factors involved in these pathways is required to develop cell-based therapies such as β-cell transplantation for conditions such as diabetes mellitus. One versatile factor controlling both processes as well as a network of other proteins involved in pancreatic and duodenal development is the transcription factor SOX9. This review will focus on a comparison of SOX9 function during progenitor expansion and differentiation in the developing pancreas and duodenum with specific focus on endocrine development. During human pancreatic development, SOX9 functions in a dose-dependent manner to regulate epithelial progenitor expansion and endocrine differentiation. SOX9 expression is eventually limited to a subset of ductal and centroacinar cells, hypothesized to be the pancreatic stem cell compartment. Similarly, during duodenal development, SOX9 is expressed in most early epithelial progenitors and becomes gradually restricted to proliferative progenitors in the lower crypts, as well as mature Paneth and enteroendocrine cells indicating some differences in functional roles. However, in both developmental contexts, SOX9 is involved in pathways responsible for cellular proliferation and differentiation, such as Notch and Wnt. With its adaptable and central function in progenitor control, SOX9 represents an attractive target for manipulation for in vitro progenitor expansion and differentiation meriting further investigation.
journal_name
Stem Cells Devjournal_title
Stem cells and developmentauthors
Belo J,Krishnamurthy M,Oakie A,Wang Rdoi
10.1089/scd.2013.0106subject
Has Abstractpub_date
2013-11-15 00:00:00pages
2935-43issue
22eissn
1547-3287issn
1557-8534journal_volume
22pub_type
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2010.0180
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2011.0073
更新日期:2012-01-01 00:00:00
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2016.0346
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2015.0262
更新日期:2016-01-01 00:00:00
abstract::Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the developing fetus, and may represent a novel source of stem cells for cell therapy. In this study, we examined the paracrine factors released by human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) and their ability to...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2009.0138
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2008.0021
更新日期:2009-03-01 00:00:00
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journal_title:Stem cells and development
pub_type: 社论
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更新日期:2008-10-01 00:00:00
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2017.0262
更新日期:2018-06-15 00:00:00
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journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2006.15.124
更新日期:2006-02-01 00:00:00
abstract::Traumatic spinal cord injury (SCI) leads to a cascade of secondary chemical insults, including oxidative stress and glutamate excitotoxicity, which damage host neurons and glia. Transplantation of exogenous neural stem/progenitor cells (NSPCs) has shown promise in enhancing regeneration after SCI, although survival of...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2015.0389
更新日期:2016-08-15 00:00:00
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journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
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journal_title:Stem cells and development
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journal_title:Stem cells and development
pub_type: 杂志文章,评审
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2016.0072
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2014.0503
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journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2016.0334
更新日期:2017-06-01 00:00:00
abstract::Traditionally, undifferentiated pluripotent human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) have been expanded as monolayer colonies in adhesion culture, both in the presence or absence of feeder cells. However, the use of pluripotent stem cells poses the need to scale-up current culture methods....
journal_title:Stem cells and development
pub_type: 杂志文章
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abstract::Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long culture history. Several mechanisms were described to account for this capability. Since several of the described mechanis...
journal_title:Stem cells and development
pub_type: 杂志文章
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journal_title:Stem cells and development
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
abstract::To develop biological approaches to restore vision, we developed a method of transplanting stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat). Human embryonic stem cells (hESC) were differentiated to retinal organoids in a dish. hESC-derived retinal tissue was introduced into ...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2019.0090
更新日期:2019-09-01 00:00:00