In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice.

abstract：:The increasing use of mesenchymal stromal cells (MSC) in clinical cellular therapy requires a safe and controlled production process compliant with Good Manufacturing Practice guidelines. Pooled blood group AB human serum (HS) has been used to replace fetal bovine serum (FBS), critically rated by the regulatory agenci...

journal_title：Stem cells and development

authors： Dreher L,Elvers-Hornung S,Brinkmann I,Huck V,Henschler R,Gloe T,Klüter H,Bieback K

更新日期：2013-03-01 00:00:00

abstract：:Mesenchymal stems cells (MSCs) are a population of multipotent cells residing in several readily available adult tissue compartments, thus allowing for their ex vivo expansion. To date, therapeutic applications of MSCs have focused on their ability to hone to and support the repair of damaged tissues. More recent evid...

journal_title：Stem cells and development

authors： Reddy BY,Xu DS,Hantash BM

更新日期：2012-02-10 00:00:00

abstract：:Human embryonic stem cells (hESCs) exhibiting skewed X chromosome inactivation (XCI) have been reported. The copy number variations (CNVs), loss of heterozygosity (LOH), or single-nucleotide variant (SNV) events in those epigenetically distinct cells remain unknown, and whether such genetic abnormalities will influenc...

journal_title：Stem cells and development

authors： Liu WQ,Li JL,Wang J,He WY,Va L,Sheng XM,Wu BL,Sun XF

更新日期：2015-08-01 00:00:00

abstract：:Amniotic fluid stem cells (AFSs) are interesting mesenchymal stem cells (MSCs) that are characterized by their great potential for cell proliferation and differentiation compared with other types of MSCs identified to date. However, MSCs in prolonged culture have been found to exhibit defects in genetic stability and ...

journal_title：Stem cells and development

authors： Phermthai T,Suksompong S,Tirawanchai N,Issaragrisil S,Julavijitphong S,Wichitwiengrat S,Silpsorn D,Pokathikorn P

更新日期：2013-05-01 00:00:00

abstract：:Liver transplantation is the only radical treatment for decompensated cirrhosis, but its use is limited owing to a shortage of donors; hence, there is an urgent need for new treatments. Previously, we developed a liver-regeneration therapy using autologous bone marrow-derived mesenchymal stem cells (BMSCs), which is u...

journal_title：Stem cells and development

authors： Nishi M,Matsumoto T,Fujisawa K,Suehiro Y,Takami T,Yamamoto N,Yamasaki T,Sakaida I

更新日期：2020-11-15 00:00:00

abstract：:The central role of calcium influx and electrical activity in embryonic development raises important questions about the role and regulation of voltage-dependent calcium influx. Using cultured neural progenitor cell (NPC) preparations, we recorded barium currents through voltage-activated channels using the whole-cell...

journal_title：Stem cells and development

authors： Louhivuori LM,Louhivuori V,Wigren HK,Hakala E,Jansson LC,Nordström T,Castrén ML,Akerman KE

更新日期：2013-04-15 00:00:00

abstract：:Bone marrow-mesenchymal stem cells (BM-MSC) ameliorate renal dysfunction and repair tubular damage of acute kidney injury by locally releasing growth factors, including the insulin-like growth factor-1 (IGF-1). The restricted homing of BM-MSC at the site of injury led us to investigate a possible gene-based communicat...

journal_title：Stem cells and development

authors： Tomasoni S,Longaretti L,Rota C,Morigi M,Conti S,Gotti E,Capelli C,Introna M,Remuzzi G,Benigni A

更新日期：2013-03-01 00:00:00

abstract：:The mental retardation-associated protein, srGAP3 is highly expressed in neurogenic sites. It is thought to regulate the key aspects of neuronal development and functions. Little is known about the interaction between srGAP3 and immature neural stem cells/neural progenitor cells (NSCs/NPCs). In the current study, the ...

journal_title：Stem cells and development

authors： Lu H,Jiao Q,Wang Y,Yang Z,Feng M,Wang L,Chen X,Jin W,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...

journal_title：Stem cells and development

authors： Helm A,Arrizabalaga O,Pignalosa D,Schroeder IS,Durante M,Ritter S

更新日期：2016-01-15 00:00:00

abstract：:Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic printing. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using chromatin immunoprecipitation (ChIP)-polymerase chain reaction and ChI...

journal_title：Stem cells and development

authors： Leschik J,Caron L,Yang H,Cowan C,Pucéat M

更新日期：2015-02-01 00:00:00

abstract：:Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence r...

journal_title：Stem cells and development

authors： Raad S,David A,Que J,Faure C

更新日期：2020-08-01 00:00:00

abstract：:Primordial germ cells (PGCs), the precursors of gametes, have regulatory mechanisms involving transcription factors and epigenetic modifications. The transcription factor NANOG is a key regulator of germ cell and embryonic stem cell characteristics. However, the epigenetic regulation of NANOG with a histone deacetylas...

journal_title：Stem cells and development

authors： Jung HG,Hwang YS,Park YH,Cho HY,Rengaraj D,Han JY

更新日期：2018-09-01 00:00:00

abstract：:The CD34 surface antigen has been recognized as a marker of hematopoietic stem cells (HSCs) and is widely used for HSC selection as well as for quality control in HSC transplantation. CD34 has been implicated in cytoadhesion signaling, and its expression has been suggested to reflect the activation state of hematopoie...

journal_title：Stem cells and development

authors： Lange C,Li Z,Fang L,Baum C,Fehse B

更新日期：2007-04-01 00:00:00

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00

abstract：:The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. Th...

journal_title：Stem cells and development

authors： Xie Y,Awonuga A,Liu J,Rings E,Puscheck EE,Rappolee DA

更新日期：2013-05-15 00:00:00

abstract：:Ochratoxin A (OTA) is a ubiquitous fungal metabolite with nephrotoxic, carcinogenic, and apoptotic potential. Although the toxic effects of OTA in various cell types are well characterized, it is not known whether OTA has an effect on stem cell differentiation. In this study, we demonstrate that OTA inhibits adipogene...

journal_title：Stem cells and development

authors： Lim S,Jang HJ,Kim JK,Kim JM,Park EH,Yang JH,Kim YH,Yea K,Ryu SH,Suh PG

更新日期：2011-03-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Inducing a stable and predictable program of neural cell fate in pluripotent cells in vitro is an important goal for utilizing these cells for modeling human disease mechanisms. However, the extent to which in vitro neural specification recapitulates in vivo neural specification remains to be fully established. We pre...

journal_title：Stem cells and development

authors： Dang LT,Wong L,Tropepe V

更新日期：2012-10-10 00:00:00

abstract：:Aneurysm refers to the dilation of the vessel wall for more than 50%. Abdominal aortic aneurysm (AAA) refers to the dilation and weakening of all three layers of the abdominal aorta, which mostly occur infrarenally. The population aged above 50 years is at risk of AAA development, while a familiar history doubles the ...

journal_title：Stem cells and development

authors： Parvizi M,Harmsen MC

更新日期：2015-07-01 00:00:00

abstract：:Chronic idiopathic neutropenia (CIN) is a granulopoiesis disorder associated with an inhibitory bone marrow (BM) microenvironment consisting of activated T-lymphocytes and pro-inflammatory mediators. In this study, we investigated the possible involvement of BM mesenchymal stem cells (MSCs) in the pathophysiology of C...

journal_title：Stem cells and development

authors： Stavroulaki E,Kastrinaki MC,Pontikoglou C,Eliopoulos D,Damianaki A,Mavroudi I,Pyrovolaki K,Katonis P,Papadaki HA

更新日期：2011-08-01 00:00:00

abstract：:Balanced and precisely controlled processes between self-renewal and differentiation of hematopoietic stem cells (HSCs) into all blood lineages are critical for vertebrate definitive hematopoiesis. However, the molecular mechanisms underlying the maintenance and differentiation of HSCs have not been fully elucidated. ...

journal_title：Stem cells and development

authors： Hirabayashi R,Hozumi S,Higashijima S,Kikuchi Y

更新日期：2013-09-15 00:00:00

abstract：:Occupational asthma (OA) is characterized by allergic airway inflammation and hyperresponsiveness, leading to progressive airway remodeling and a concomitant decline in lung function. The management of OA remains suboptimal in clinical practice. Thus, establishing effective therapies might overcome the natural history...

journal_title：Stem cells and development

authors： Martínez-González I,Cruz MJ,Moreno R,Morell F,Muñoz X,Aran JM

更新日期：2014-10-01 00:00:00

abstract：:Oligodendrogenesis encompasses lineage specification of neural progenitor cells (NPCs) and differentiation into oligodendrocytes that ultimately culminates in the myelination of central nervous system axons. Each individual process must be tightly regulated by extracellular and cell-intrinsic mechanisms, whose identit...

journal_title：Stem cells and development

authors： Steffenhagen C,Dechant FX,Oberbauer E,Furtner T,Weidner N,Küry P,Aigner L,Rivera FJ

更新日期：2012-07-20 00:00:00

abstract：:Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous system, and induced pluripotent stem cells (iPSCs) are envisioned to b...

journal_title：Stem cells and development

authors： Umebayashi D,Coles B,van der Kooy D

更新日期：2016-05-01 00:00:00

abstract：:A long-term goal of mesenchymal progenitor cell (MPC) research is to identify cell-surface markers to facilitate MPC isolation. One reported MPC feature in humans and other species is lack of CD14 (lipopolysaccharide receptor) expression. The aim of this study was to evaluate CD14 as an MPC sorting marker. Our hypothe...

journal_title：Stem cells and development

authors： Hackett CH,Flaminio MJ,Fortier LA

更新日期：2011-04-01 00:00:00

abstract：:A murine stromal cell line (OP9-DL1) expressing a notch ligand, Delta-like-1, has been shown to be able to drive the differentiation of both murine and human hematopoietic progenitors into T cells in vitro. Further studies showed that hematopoietic progenitors transduced by a retroviral vector to express a human CD8 T...

journal_title：Stem cells and development

authors： Dai B,Wang P

更新日期：2009-03-01 00:00:00

abstract：:There is an increasing need for an animal model that can be used to translate basic research into clinical therapy. We documented the differentiation and functional competence of embryonic stem cell (ESC)-derived endothelial cells in baboons. Baboon angioblasts were sequentially differentiated from embryoid body cultu...

journal_title：Stem cells and development

authors： Shi Q,Hodara V,Simerly CR,Schatten GP,VandeBerg JL

更新日期：2013-02-15 00:00:00

abstract：:Body axes and germ layers evolve at gastrulation, and in mammals are driven by many genes; however, what orchestrates the genetic pathways during gastrulation remains elusive. Previously, we presented evidence that microRNA-17 (miRNA-17) family members, miR-17-5p, miR-20a, miR-93, and miR-106a were differentially expr...

journal_title：Stem cells and development

authors： Larabee SM,Coia H,Jones S,Cheung E,Gallicano GI

更新日期：2015-02-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) possess multilineage differentiation potential and can be used for the treatment of diabetic heart failure. However, hyperglycemia can affect the function of MSCs adversely and merits the requirement for a strategy to correct this anomaly. MSCs were isolated from the t...

journal_title：Stem cells and development

authors： Khan M,Akhtar S,Mohsin S,N Khan S,Riazuddin S

更新日期：2011-01-01 00:00:00

abstract：:The optimization of defined growth conditions is necessary for the development of clinical application of human embryonic stem cells (hESCs). Current research has focused on developing defined media formulations for long-term culture of hESCs with little attention on the establishment of defined substrates for hESC pr...

journal_title：Stem cells and development

authors： Brafman DA,Shah KD,Fellner T,Chien S,Willert K

更新日期：2009-10-01 00:00:00