Abstract:
:Mesenchymal stems cells (MSCs) are a population of multipotent cells residing in several readily available adult tissue compartments, thus allowing for their ex vivo expansion. To date, therapeutic applications of MSCs have focused on their ability to hone to and support the repair of damaged tissues. More recent evidence suggests that MSCs possess low immunogenicity and a diverse array of immunosuppressive properties. In thisarticle, we will review the basic biology of bone marrow-derived MSCs including their immunoregulatory effects and the putative mechanisms underlying them. We will then present some of the recent clinical applications of MSCs that have leveraged these effects for the treatment of immune-mediated dermatoses such as graft-versus-host disease and systemic lupus erythematosus. Although MSCs offer great therapeutic promise, we will also highlight a number of pertinent challenges that should be overcome before their successful clinical translation.
journal_name
Stem Cells Devjournal_title
Stem cells and developmentauthors
Reddy BY,Xu DS,Hantash BMdoi
10.1089/scd.2011.0404subject
Has Abstractpub_date
2012-02-10 00:00:00pages
352-62issue
3eissn
1547-3287issn
1557-8534journal_volume
21pub_type
杂志文章,评审abstract::Bone marrow (BM)-derived mesenchymal stromal cells (MSCs) frequently display alterations in several hematologic disorders, such as acute lymphoid leukemia, acute myeloid leukemia (AML), and myelodysplastic syndromes. In acute leukemias, it is not clear whether MSC alterations contribute to the development of the malig...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2016.0295
更新日期:2017-05-15 00:00:00
abstract::The enhanced proliferation of mesenchymal stem cells (MSCs) can be helpful for the clinical translation of cell therapy. Low-level laser irradiation (LLLI) has been demonstrated as regulating MSC proliferation. MicroRNAs (miRNAs) are involved in various pathophysiologic processes in stem cells, but the role of miRNAs ...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2011.0695
更新日期:2012-09-01 00:00:00
abstract::The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. Th...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2012.0352
更新日期:2013-05-15 00:00:00
abstract::The induction and detection of chemotactic migration in mesenchymal stem cells (MSC) are complicated by their adherent nature. We describe here the experimental details for inducing the transmigration of MSC seeded in microchemotaxis chambers and reliably identifying the translocated cells. A combination of 8-microm p...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2005.14.231
更新日期:2005-04-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The most potent ligand of the AhR known is 2,3,7,8-tetracholorodibenzo-p-dioxin. We previously reported tetrachlorodibenzo-p-dioxin-induced...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2010.0333
更新日期:2011-05-01 00:00:00
abstract::We describe a rapid and efficient 5-step program of defined factors for the genesis of brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells (ESCs). The OLs emerge on the same time frame in vitro as seen in vivo. Factors promoting neural induction (retinoids, noggin) are required, while exogenous Sonic...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2009.0520
更新日期:2010-09-01 00:00:00
abstract::Cell replacement therapy holds great promise for treating a wide range of human disorders. However, ensuring the predictable differentiation of transplanted stem cells, eliminating their risk of tumor formation, and generating fully functional cells after transplantation remain major challenges in regenerative medicin...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2010.0555
更新日期:2011-11-01 00:00:00
abstract::Multipotent bone marrow-derived mesenchymal stem/stromal cells (BMSCs) exhibit a finite life span after ex vivo expansion leading to cellular senescence. Many factors can contribute to this. Recently, our group has identified for the first time expression of the chemokine-like factor superfamily 8 (CMTM8) gene in cult...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2020.0007
更新日期:2020-07-01 00:00:00
abstract::Regenerative medicine, a paragon of future healthcare, holds unprecedented potential in extending the reach of treatment modalities for individuals across diseases and lifespan. Emerging regenerative technologies, focused on structural repair and functional restoration, signal a radical transformation in medical and s...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2013.0448
更新日期:2013-12-01 00:00:00
abstract::Primordial germ cells (PGCs), the precursors of gametes, have regulatory mechanisms involving transcription factors and epigenetic modifications. The transcription factor NANOG is a key regulator of germ cell and embryonic stem cell characteristics. However, the epigenetic regulation of NANOG with a histone deacetylas...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2018.0059
更新日期:2018-09-01 00:00:00
abstract::Multipotent stem/progenitor cells from bone marrow stroma (mesenchymal stromal cells or MSCs) were previously shown to enhance proliferation and differentiation of neural stem cells (NSCs) in vivo, but the molecular basis of the effect was not defined. Here coculturing human MSCs (hMSCs) with rat NSCs (rNSCs) was foun...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2009.0444
更新日期:2011-02-01 00:00:00
abstract::Embryonic stem cells (ESCs) posses the ability to self-renew and differentiate into a multitude of lineages, including the osteogenic lineage in vitro. Currently, most approaches have focused on embryonic body (EB)-mediated osteogenic differentiation, which relies on formation of all three germ layers resulting in lim...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2007.0228
更新日期:2008-10-01 00:00:00
abstract::Adipose tissue (AT) is composed of mature adipocytes and stromal vascular fraction (SVF) cells, including adipose stem/stromal cells (ASCs). We characterized hematopoietic cells residing in human nonobese AT by analyzing the SVF isolated from human lipoaspirates and peripheral blood (PB). Flow cytometry revealed that ...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2012.0442
更新日期:2013-03-15 00:00:00
abstract::Nonpluripotent neural progenitor cells (NPCs) derived from the human fetal central nervous system were found to express a number of messenger RNA (mRNA) species associated with pluripotency, such as NANOG, REX1, and OCT4. The expression was restricted to small subpopulations of NPCs. In contrast to pluripotent stem ce...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2016.0346
更新日期:2017-06-15 00:00:00
abstract::Human perivascular progenitor cells, including pericytes, are well-described multipotent mesenchymal cells giving rise to mesenchymal stem cells in culture. Despite the unique location of pericytes, specific antigens to distinguish human pericytes from other cell types are few. Here, we employed a human tissue microar...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2019.0106
更新日期:2019-09-15 00:00:00
abstract::Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence r...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2020.0075
更新日期:2020-08-01 00:00:00
abstract::Regenerating islet (Reg) proteins are involved in the proliferation and differentiation of diverse cell types. However, whether embryonic stem cells (ESCs) express Reg genes and their corresponding proteins remains unknown. In this study, we probed the expression of Reg family members by mouse ESCs (mESCs). Mouse Reg1...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2009.0398
更新日期:2010-09-01 00:00:00
abstract::Osteogenesis imperfecta (OI) is a genetic bone pathology with prenatal onset, characterized by brittle bones in response to abnormal collagen composition. There is presently no cure for OI. We previously showed that human first trimester fetal blood mesenchymal stem cells (MSCs) transplanted into a murine OI model (oi...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2013.0132
更新日期:2014-02-01 00:00:00
abstract::Fluorescence in situ hybridization (FISH) was used to analyze peripheral blood stem cells (PBSC) and stem cell assays (SCA) derived from them in 2 patients with acute myeloid leukemia (AML) with trisomy 8 as the sole chromosome abnormality prior to undergoing autologous stem cell transplantation. In both cases, the de...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/154732804773099227
更新日期:2004-02-01 00:00:00
abstract::Non-tumorous liver tissue removed during surgery to resect hepatocellular carcinoma (HCC) is potentially a useful source of material from which cells, particularly liver progenitor/stem cells (LPCs), can be isolated to establish cell lines. The purpose of this study was to evaluate the applicability of the "plate-and-...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2009.0304
更新日期:2010-08-01 00:00:00
abstract::Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with significant morbidity and mortality, and it often leads to poor clinical outcome. Although great efforts have been made toward animal and clinical studies, optimal therapy of SAH remains a challenge for scientists and clinicians. Increasing evidence su...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2019.0219
更新日期:2020-02-15 00:00:00
abstract::In this work, we evaluated the expansion of human hematopoietic stem cells from umbilical cord blood in roller bottles. The Iscove's modified Dulbecco's medium, the Stem Pro 34-SFM medium, and the L-15 Leibovitz's medium for cultures in CO(2)-free atmosphere were assessed. At day 5 of culture, total colony forming uni...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2010.0236
更新日期:2011-04-01 00:00:00
abstract::Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2015.0260
更新日期:2016-01-15 00:00:00
abstract::The optimization of defined growth conditions is necessary for the development of clinical application of human embryonic stem cells (hESCs). Current research has focused on developing defined media formulations for long-term culture of hESCs with little attention on the establishment of defined substrates for hESC pr...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2008.0410
更新日期:2009-10-01 00:00:00
abstract::Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some SC types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2013.0204
更新日期:2013-11-15 00:00:00
abstract::Myocardial infarction (MI) results in loss of myofibers in the ischemic zone of the heart, followed by scar formation. These factors increase barriers to mobilization of mesenchymal stem cells (MSC), thereby impeding their effectiveness in cardiac repair. This study examined MSC overexpressing CXCR4 (MSC(CX4)) to dete...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2011.0126
更新日期:2012-03-20 00:00:00
abstract::Previous studies have transplanted a variety of neural stem cells (NSCs) to the eye in hopes of developing a therapy to replace retinal neurons lost to disease. Successful integration, survival, and differentiation of the cell types has been variably successful. At the moment, little is known about the fundamental bio...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2007.0051
更新日期:2008-02-01 00:00:00
abstract::Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2011.0280
更新日期:2012-05-20 00:00:00
abstract::The development of methods to induce differentiation of human mesenchymal stem cells (hMSCs) has opened the possibility of using these cells in regenerative or reparative therapies. However, the low frequency of hMSCs in tissue means it is often necessary to expand these cells extensively in vitro. In this study, we e...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2007.0185
更新日期:2008-10-01 00:00:00
abstract::Improvement in angiogenesis using mesenchymal stem cells (MSCs) is evolving as an option in patients with vascular insufficiencies. The paracrine factors secreted by MSCs have been attributed to the angiogenic response. This study was conducted to identify the factors secreted by umbilical cord-derived MSCs (UCMSCs) t...
journal_title:Stem cells and development
pub_type: 杂志文章
doi:10.1089/scd.2014.0184
更新日期:2015-02-15 00:00:00