Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers.

abstract：:Members of helix-loop-helix (HLH) protein family of Id (inhibitor of differentiation) dimerize with bHLH transcription factors and function as negative regulators of differentiation during development. Most of inhibitory roles of Id proteins have been demonstrated in non-neural tissues, and their roles in the developi...

journal_title：Stem cells and development

authors： Jung S,Park RH,Kim S,Jeon YJ,Ham DS,Jung MY,Kim SS,Lee YD,Park CH,Suh-Kim H

更新日期：2010-06-01 00:00:00

abstract：:Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. However, it is essential to unde...

journal_title：Stem cells and development

authors： Tatebayashi K,Tanaka Y,Nakano-Doi A,Sakuma R,Kamachi S,Shirakawa M,Uchida K,Kageyama H,Takagi T,Yoshimura S,Matsuyama T,Nakagomi T

更新日期：2017-06-01 00:00:00

abstract：:Previous studies have transplanted a variety of neural stem cells (NSCs) to the eye in hopes of developing a therapy to replace retinal neurons lost to disease. Successful integration, survival, and differentiation of the cell types has been variably successful. At the moment, little is known about the fundamental bio...

journal_title：Stem cells and development

authors： Dunn-Thomas TE,Dobbs DL,Sakaguchi DS,Young MJ,Honovar VG,Greenlee MH

更新日期：2008-02-01 00:00:00

abstract：:Smooth muscle cell (SMC) differentiation and dedifferentiation play a critical role in the pathogenesis of cardiovascular diseases. The lack of a good and simple in vitro SMC differentiation system has hampered the progress of SMC field for years. The generation of such an in vitro system would be invaluable for explo...

journal_title：Stem cells and development

authors： Xie CQ,Huang H,Wei S,Song LS,Zhang J,Ritchie RP,Chen L,Zhang M,Chen YE

更新日期：2009-06-01 00:00:00

abstract：:Primordial germ cells (PGCs), the precursors of gametes, have regulatory mechanisms involving transcription factors and epigenetic modifications. The transcription factor NANOG is a key regulator of germ cell and embryonic stem cell characteristics. However, the epigenetic regulation of NANOG with a histone deacetylas...

journal_title：Stem cells and development

authors： Jung HG,Hwang YS,Park YH,Cho HY,Rengaraj D,Han JY

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to clarify the mechanisms that regulate hematopoietic cell expansion in vitro by identifying defined culture conditions. We report the results of experiments with CD34(+) cells from cord blood (CB, n = 13), bone marrow (BM, n = 4), and mobilized peripheral blood stem cells (PBSC, n = 5) using...

journal_title：Stem cells and development

authors： Rossi B,Zanolin E,Vincenzi C,Diani F,Pizzolo G,de Wynter E,Nadali G

更新日期：2004-08-01 00:00:00

abstract：:Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites o...

journal_title：Stem cells and development

authors： Hochheuser C,Windt LJ,Kunze NY,de Vos DL,Tytgat GAM,Voermans C,Timmerman I

更新日期：2021-01-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are somatic cells that have been reprogrammed to a pluripotent state via introduction of defined transcription factors. iPSCs are a valuable resource for regenerative medicine, but whether iPSCs are identical to embryonic stem cells (ESCs) remains unclear. In this study, we perfo...

journal_title：Stem cells and development

authors： Kim SY,Kim MJ,Jung H,Kim WK,Kwon SO,Son MJ,Jang IS,Choi JS,Park SG,Park BC,Han YM,Lee SC,Cho YS,Bae KH

更新日期：2012-05-20 00:00:00

abstract：:Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...

journal_title：Stem cells and development

authors： Wu JH,Wang HJ,Tan YZ,Li ZH

更新日期：2012-05-20 00:00:00

abstract：:Myocardial infarction is a major public health problem that causes significant mortality despite recent advances in its prevention and treatment. Therefore, approaches based on adult stem cells represent a promising alternative to conventional therapies for this life-threatening condition. Mesenchymal stem cells (MSCs...

journal_title：Stem cells and development

authors： Armiñán A,Gandía C,Bartual M,García-Verdugo JM,Lledó E,Mirabet V,Llop M,Barea J,Montero JA,Sepúlveda P

更新日期：2009-07-01 00:00:00

abstract：:The optimization of defined growth conditions is necessary for the development of clinical application of human embryonic stem cells (hESCs). Current research has focused on developing defined media formulations for long-term culture of hESCs with little attention on the establishment of defined substrates for hESC pr...

journal_title：Stem cells and development

authors： Brafman DA,Shah KD,Fellner T,Chien S,Willert K

更新日期：2009-10-01 00:00:00

abstract：:Bone marrow human mesenchymal stem cells (hMSCs) are known to survive in serum-free media, when most normal somatic cells do not survive. We found that the endogenously-activated bone morphogenetic protein (BMP) pathway is involved in this cellular behavior. Under this culture condition, phosphorylated Smad1 (PSmad1),...

journal_title：Stem cells and development

authors： Solmesky LJ,Abekasis M,Bulvik S,Weil M

更新日期：2009-11-01 00:00:00

abstract：:In this work, we evaluated the expansion of human hematopoietic stem cells from umbilical cord blood in roller bottles. The Iscove's modified Dulbecco's medium, the Stem Pro 34-SFM medium, and the L-15 Leibovitz's medium for cultures in CO(2)-free atmosphere were assessed. At day 5 of culture, total colony forming uni...

journal_title：Stem cells and development

authors： Andrade-Zaldívar H,Kalixto-Sánchez MA,de la Rosa AP,De León-Rodríguez A

更新日期：2011-04-01 00:00:00

abstract：:Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in different clinical presentations, with variable penetrance, are unknown. To better understand the m...

journal_title：Stem cells and development

authors： De Los Angeles A,Tunbridge EM

更新日期：2020-09-01 00:00:00

abstract：:In this study we examine whether a somatic cell, once returned to a pluripotent state, gains the ability to reprogram other somatic cells. We reprogrammed mouse embryonic fibroblasts by viral induction of oct4, sox2, c-myc, and klf-4 genes. Upon fusion of the resulting iPS cells with somatic cells harboring an Oct4-GF...

journal_title：Stem cells and development

authors： Sumer H,Jones KL,Liu J,Heffernan C,Tat PA,Upton KR,Verma PJ

更新日期：2010-02-01 00:00:00

abstract：:Individuals with neurodegenerative disorders or brain injury have few treatment options and it has been proposed that endogenous adult neural stem cells can be harnessed to repopulate dysfunctional nonneurogenic regions of the brain. We have accomplished this through the development of rationally designed hydrogel imp...

journal_title：Stem cells and development

authors： Clark AR,Carter AB,Hager LE,Price EM

更新日期：2016-08-01 00:00:00

abstract：:Human embryonic stem (hES) cells represent a potentially unlimited source of transplantable beta-cells for the treatment of diabetes. Here we describe a differentiation strategy that reproducibly directs HES3, an National Institutes of Health (NIH)-registered hES cell line, into cells of the pancreatic endocrine linea...

journal_title：Stem cells and development

authors： Phillips BW,Hentze H,Rust WL,Chen QP,Chipperfield H,Tan EK,Abraham S,Sadasivam A,Soong PL,Wang ST,Lim R,Sun W,Colman A,Dunn NR

更新日期：2007-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be mobilized from the bone marrow and enter the circulation. Conversely, MSCs can be recruited from the circulation and into the bone marrow. For these migratory pathways, MSCs have to traverse the bone marrow endothelium, in a basal-to-apical and apical-to-basal direction, respective...

journal_title：Stem cells and development

authors： Smith H,Whittall C,Weksler B,Middleton J

更新日期：2012-02-10 00:00:00

abstract：:Embryonic stem (ES) cells are recognized as an excellent cell culture model for studying developmental mechanisms and their therapeutic modulations. The aim of this work was to define whether using magnetofection was an efficient way to manipulate stem cells genetically without adversely affecting their proliferation ...

journal_title：Stem cells and development

authors： Lee CH,Kim EY,Jeon K,Tae JC,Lee KS,Kim YO,Jeong MY,Yun CW,Jeong DK,Cho SK,Kim JH,Lee HY,Riu KZ,Cho SG,Park SP

更新日期：2008-02-01 00:00:00

abstract：:The mental retardation-associated protein, srGAP3 is highly expressed in neurogenic sites. It is thought to regulate the key aspects of neuronal development and functions. Little is known about the interaction between srGAP3 and immature neural stem cells/neural progenitor cells (NSCs/NPCs). In the current study, the ...

journal_title：Stem cells and development

authors： Lu H,Jiao Q,Wang Y,Yang Z,Feng M,Wang L,Chen X,Jin W,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:Traditionally, undifferentiated pluripotent human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) have been expanded as monolayer colonies in adhesion culture, both in the presence or absence of feeder cells. However, the use of pluripotent stem cells poses the need to scale-up current culture methods....

journal_title：Stem cells and development

authors： Larijani MR,Seifinejad A,Pournasr B,Hajihoseini V,Hassani SN,Totonchi M,Yousefi M,Shamsi F,Salekdeh GH,Baharvand H

更新日期：2011-11-01 00:00:00

abstract：:Aneurysm refers to the dilation of the vessel wall for more than 50%. Abdominal aortic aneurysm (AAA) refers to the dilation and weakening of all three layers of the abdominal aorta, which mostly occur infrarenally. The population aged above 50 years is at risk of AAA development, while a familiar history doubles the ...

journal_title：Stem cells and development

authors： Parvizi M,Harmsen MC

更新日期：2015-07-01 00:00:00

abstract：:A common observation in metabolic disorders and aging is the elevation of free fatty acids, which can form ectopic fat deposition and result in lipotoxicity. Ectopic fat deposition of skeletal muscle has been recognized as an important component of aging, frailty and sarcopenia. Previous studies have suggested that li...

journal_title：Stem cells and development

authors： Xue M,Zhang F,Ji X,Yu H,Jiang X,Qiu Y,Yu J,Chen J,Yang F,Bao Z

更新日期：2021-01-11 00:00:00

abstract：:Members of the homeobox (Hox) gene family are known to mediate expansion of hematopoietic stem cells (HSCs) and progenitors. The absence of oncogenic properties promoted HOXB4 as prime candidate in the quest to expand HSCs for clinical purposes. Despite its potential to expand HSCs, studies with mutant mice showed tha...

journal_title：Stem cells and development

authors： Fournier M,Lebert-Ghali CÉ,Krosl G,Bijl JJ

更新日期：2012-01-01 00:00:00

abstract：:Intermediate progenitor populations play a crucial role in the regional specification and differentiation of the cranial neural crest. On the basis of global gene expression profiles, gene cohort expression levels, and epigenetic modifications, we have defined key factors involved in the differentiation of dental foll...

journal_title：Stem cells and development

authors： Dangaria SJ,Ito Y,Luan X,Diekwisch TG

更新日期：2011-01-01 00:00:00

abstract：:Bone marrow-mesenchymal stem cells (BM-MSC) ameliorate renal dysfunction and repair tubular damage of acute kidney injury by locally releasing growth factors, including the insulin-like growth factor-1 (IGF-1). The restricted homing of BM-MSC at the site of injury led us to investigate a possible gene-based communicat...

journal_title：Stem cells and development

authors： Tomasoni S,Longaretti L,Rota C,Morigi M,Conti S,Gotti E,Capelli C,Introna M,Remuzzi G,Benigni A

更新日期：2013-03-01 00:00:00

abstract：:Administration of human bone marrow-derived mesenchymal stem cells (BM-MSCs) significantly alleviates allergic airway inflammation. There are no studies that refer to the role of microRNAs (miRNAs) after the BM-MSCs treatment in airway allergic inflammation. We induced a mouse model of asthma and performed the transpl...

journal_title：Stem cells and development

authors： Tang GN,Li CL,Yao Y,Xu ZB,Deng MX,Wang SY,Sun YQ,Shi JB,Fu QL

更新日期：2016-06-15 00:00:00

abstract：:Cardiac stem/progenitors are being used in the clinic to treat patients with a range of cardiac pathologies. However, improvements in heart function following treatment have been reported to be variable, with some showing no response. This discrepancy in response remains unresolved. Mesenchymal stem cells (MSCs) have ...

journal_title：Stem cells and development

authors： Oldershaw R,Owens WA,Sutherland R,Linney M,Liddle R,Magana L,Lash GE,Gill JH,Richardson G,Meeson A

更新日期：2019-05-01 00:00:00

abstract：:Misexpression of the double homeodomain protein DUX4 in muscle is believed to cause facioscapulohumeral muscular dystrophy (FSHD). Although strategies are being devised to inhibit DUX4 activity in FSHD, there is little known about the normal function of this protein. Expression of DUX4 has been reported in pluripotent...

journal_title：Stem cells and development

authors： Dandapat A,Hartweck LM,Bosnakovski D,Kyba M

更新日期：2013-09-01 00:00:00

abstract：:Mouse Embryonic Stem Cells (mESCs) are unique in their self-renewal and pluripotency. Hypothetically, mESCs model gestational stress effects or stresses of in vitro fertilization/assisted reproductive technologies or drug/environmental exposures that endanger embryos. Testing mESCs stress responses should diminish and...

journal_title：Stem cells and development

authors： Li Q,Louden E,Zhou J,Drewlo S,Dai J,Puscheck EE,Chen K,Rappolee DA

更新日期：2019-01-15 00:00:00