Chemokines stimulate bidirectional migration of human mesenchymal stem cells across bone marrow endothelial cells.

abstract：:Several reports have shown that the expression of Sca-1 (Ly-6A/E), the most widely used murine hematopoietic stem cell marker, is restricted to blood vessels in several nonhematopoietic tissues. However, there is no information about which components are expressing Sca-1, and what the role of Sca-1 could be. Because w...

journal_title：Stem cells and development

authors： Luna G,Paez J,Cardier JE

更新日期：2004-10-01 00:00:00

abstract：:Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe adverse reaction, which results in progressive bone destruction in the maxillofacial region of patients. To date, the pathological mechanisms remain largely unclear. Recently, we found that BRONJ patient had significantly deep periodontal pockets and...

journal_title：Stem cells and development

authors： Li M,Yu Y,Shi Y,Zhou Y,Zhang W,Hua H,Ge J,Zhang Z,Ye D,Yang C,Wang S

更新日期：2020-02-01 00:00:00

abstract：:Intermediate progenitor populations play a crucial role in the regional specification and differentiation of the cranial neural crest. On the basis of global gene expression profiles, gene cohort expression levels, and epigenetic modifications, we have defined key factors involved in the differentiation of dental foll...

journal_title：Stem cells and development

authors： Dangaria SJ,Ito Y,Luan X,Diekwisch TG

更新日期：2011-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) self-renew indefinitely as highly organized pluripotent colonies. Unlike mouse pluripotent stem cell colonies, human colonies form a uniform, flat, epithelium-like monolayer. Interestingly, it has been reported that colony morphology is closely correlated with the maintenance of plur...

journal_title：Stem cells and development

authors： Kim JM,Moon SH,Park SJ,Lee HY,Hong KS,Seo J,Bae YS,Chung HM

更新日期：2013-01-15 00:00:00

abstract：:Human perivascular progenitor cells, including pericytes, are well-described multipotent mesenchymal cells giving rise to mesenchymal stem cells in culture. Despite the unique location of pericytes, specific antigens to distinguish human pericytes from other cell types are few. Here, we employed a human tissue microar...

journal_title：Stem cells and development

authors： Hsu CY,Salazar MG,Miller S,Meyers C,Ding C,Hardy W,Péault B,James AW

更新日期：2019-09-15 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:The quality of hematopoietic stem cells (HSCs) is essentially defined by two characteristics, i.e., multilineage differentiation and self-renewal capacity. Thus, it is of high priority to clarify mechanisms that regulate these functions and to understand them at the molecular level. In the present study, we investigat...

journal_title：Stem cells and development

authors： Schraml E,Voglauer R,Fortschegger K,Sibilia M,Stelzer I,Grillari J,Schauenstein K

更新日期：2008-04-01 00:00:00

abstract：:Human stem cells from various sources have potential therapeutic applications. The clinical implementation of these therapies introduces the need for methods of noninvasive tracking of cells. The purpose of this study was to evaluate a high resolution magnetic resonance imaging (MRI) technique for in vivo detection an...

journal_title：Stem cells and development

authors： Delo DM,Olson J,Baptista PM,D'Agostino RB Jr,Atala A,Zhu JM,Soker S

更新日期：2008-12-01 00:00:00

abstract：:Mechanical cues exert considerable influence on the fates of stem cells and terminally differentiated chondrocytes. The elucidation of the interactions between cell fate and mechanical cues in nuclear mechanotransduction will provide new clues to modulate tissue homeostasis and regeneration. In this study, we used an ...

journal_title：Stem cells and development

authors： Zhong W,Tian K,Zheng X,Li L,Zhang W,Wang S,Qin J

更新日期：2013-07-15 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has multiple effects on proliferation and differentiation of human mesenchymal stem cells. Transforming growth factor-activated kinase-1 (TAK1) mediates the activation of nuclear factor-kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways in response to TNF-α. However, the r...

journal_title：Stem cells and development

authors： Lee SY,Lee JH,Shin KK,Kim DS,Kim YS,Bae YC,Jung JS

更新日期：2015-04-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of multipotent mesenchymal stem cells with immunosuppressive capacities. However, the underlying mechanisms involved in the inhibitory effects of ADSCs on T cells are not completely elucidated. In this study, human peripheral blood mononuclear cells (PBMCs) stimulated with...

journal_title：Stem cells and development

authors： Zhou K,Guo S,Tong S,Sun Q,Li F,Zhang X,Qiao Y,Liang G

更新日期：2018-09-01 00:00:00

abstract：:A common observation in metabolic disorders and aging is the elevation of free fatty acids, which can form ectopic fat deposition and result in lipotoxicity. Ectopic fat deposition of skeletal muscle has been recognized as an important component of aging, frailty and sarcopenia. Previous studies have suggested that li...

journal_title：Stem cells and development

authors： Xue M,Zhang F,Ji X,Yu H,Jiang X,Qiu Y,Yu J,Chen J,Yang F,Bao Z

更新日期：2021-01-11 00:00:00

abstract：:Members of the homeobox (Hox) gene family are known to mediate expansion of hematopoietic stem cells (HSCs) and progenitors. The absence of oncogenic properties promoted HOXB4 as prime candidate in the quest to expand HSCs for clinical purposes. Despite its potential to expand HSCs, studies with mutant mice showed tha...

journal_title：Stem cells and development

authors： Fournier M,Lebert-Ghali CÉ,Krosl G,Bijl JJ

更新日期：2012-01-01 00:00:00

abstract：:White matter damage persists in hypoxic-ischemic newborns even when treated with hypothermia. We have previously shown that intraventricular delivery of human glial progenitors (GPs) at the neonatal stage is capable of replacing abnormal host glia and rescuing the lifespan of dysmyelinated mice. However, such transpla...

journal_title：Stem cells and development

authors： Srivastava RK,Jablonska A,Chu C,Gregg L,Bulte JWM,Koehler RC,Walczak P,Janowski M

更新日期：2019-04-15 00:00:00

abstract：:Red blood cell (RBC) differentiation from human induced pluripotent stem cells (hiPSCs) offers great potential for developmental studies and innovative therapies. However, ex vivo erythropoiesis from hiPSCs is currently limited by low efficiency and unphysiological conditions of common culture systems. Especially, the...

journal_title：Stem cells and development

authors： Bernecker C,Ackermann M,Lachmann N,Rohrhofer L,Zaehres H,Araúzo-Bravo MJ,van den Akker E,Schlenke P,Dorn I

更新日期：2019-12-01 00:00:00

abstract：:Most disease-modifying therapeutic approaches in Alzheimer's disease (AD) aim to reduce the accumulation of neurotoxic amyloid-beta (Abeta) peptides as a hallmark of AD pathogenesis. Here we report the in vitro basis for a potential autologous stem cell-based strategy for widespread delivery of enzymatic activities ag...

journal_title：Stem cells and development

authors： Habisch HJ,Schmid B,von Arnim CA,Ludolph AC,Brenner R,Storch A

更新日期：2010-05-01 00:00:00

abstract：:Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cel...

journal_title：Stem cells and development

authors： Barry FP,Murphy JM,English K,Mahon BP

更新日期：2005-06-01 00:00:00

abstract：:Stem cell-based therapy is a promising treatment for neurodegenerative diseases. In our laboratory, a novel protocol has been developed to induce bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factors- secreting cells (NTF-SC), thus combining stem cell-based therapy with the NTF-based neuroprotecti...

journal_title：Stem cells and development

authors： Sadan O,Bahat-Stromza M,Barhum Y,Levy YS,Pisnevsky A,Peretz H,Ilan AB,Bulvik S,Shemesh N,Krepel D,Cohen Y,Melamed E,Offen D

更新日期：2009-10-01 00:00:00

abstract：:To be clinically relevant as a therapy for heart failure, endogenous progenitor cells must be isolated and expanded from aged and/or diseased tissue. Here, we investigated the effect of age and cardiac impairment resulting from lack of dystrophin on murine cardiosphere-derived cells (CDCs). CDCs were isolated and expa...

journal_title：Stem cells and development

authors： Hsiao LC,Perbellini F,Gomes RS,Tan JJ,Vieira S,Faggian G,Clarke K,Carr CA

更新日期：2014-05-01 00:00:00

abstract：:Embryonic stem cells (ESCs) posses the ability to self-renew and differentiate into a multitude of lineages, including the osteogenic lineage in vitro. Currently, most approaches have focused on embryonic body (EB)-mediated osteogenic differentiation, which relies on formation of all three germ layers resulting in lim...

journal_title：Stem cells and development

authors： Hwang YS,Polak JM,Mantalaris A

更新日期：2008-10-01 00:00:00

abstract：:Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...

journal_title：Stem cells and development

authors： Helm A,Arrizabalaga O,Pignalosa D,Schroeder IS,Durante M,Ritter S

更新日期：2016-01-15 00:00:00

abstract：:Misexpression of the double homeodomain protein DUX4 in muscle is believed to cause facioscapulohumeral muscular dystrophy (FSHD). Although strategies are being devised to inhibit DUX4 activity in FSHD, there is little known about the normal function of this protein. Expression of DUX4 has been reported in pluripotent...

journal_title：Stem cells and development

authors： Dandapat A,Hartweck LM,Bosnakovski D,Kyba M

更新日期：2013-09-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00

abstract：:Erythropoietin (Epo) may be considered as an endogenous stimulator of vessel growth during tumor progression through an autocrine and/or paracrine loop. The vascular effects of Epo would be relevant in tumor angiogenesis and the negative effect of Epo on tumor growth may be aggravated by its angiogenic activity. The m...

journal_title：Stem cells and development

authors： Ribatti D

更新日期：2010-01-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2) is a novel differentiation factor that is capable of inducing osteoblast differentiation and bone formation, making it an attractive option in treatment of bone defects, fractures, and spine fusions. Inflammation, which was a common situation during bone healing, is recognized to i...

journal_title：Stem cells and development

authors： Huang RL,Yuan Y,Zou GM,Liu G,Tu J,Li Q

更新日期：2014-02-01 00:00:00

abstract：:The placenta is a transient organ that develops upon the initiation of pregnancy and is essential for embryonic development and fetal survival. The rodent placenta consists of distinct lineages and includes cell types that are analogous to those that make up the human placenta. Trophoblast cells within the labyrinth l...

journal_title：Stem cells and development

authors： Carey EA,Albers RE,Doliboa SR,Hughes M,Wyatt CN,Natale DR,Brown TL

更新日期：2014-12-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors suppress bone repair and bone formation by suppressing angiogenesis as well as potentially interfering with osteoblast and osteoclast functions. In spite of these reports, there is a controversy over the exact effects of COX-2 inhibitors on bone formation processes itself. This work...

journal_title：Stem cells and development

authors： Yoon DS,Yoo JH,Kim YH,Paik S,Han CD,Lee JW

更新日期：2010-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marker and gene expression profiles. Although bone marrow is considered th...

journal_title：Stem cells and development

authors： Donders R,Bogie JFJ,Ravanidis S,Gervois P,Vanheusden M,Marée R,Schrynemackers M,Smeets HJM,Pinxteren J,Gijbels K,Walbers S,Mays RW,Deans R,Van Den Bosch L,Stinissen P,Lambrichts I,Gyselaers W,Hellings N

更新日期：2018-01-15 00:00:00

abstract：:Ex vivo cultures of human bone marrow-derived mesenchymal stem cells (MSCs) contain subsets of progenitors exhibiting dissimilar properties. One of these subsets comprises uncommitted progenitors displaying distinctive features, such as morphology, a quiescent condition, growth factor production, and restricted tissue...

journal_title：Stem cells and development

authors： Minguell JJ,Fierro FA,Epuñan MJ,Erices AA,Sierralta WD

更新日期：2005-08-01 00:00:00

abstract：:Immunodeficient mice transplanted with human hematopoietic stem cells (HSCs) have been referred to as "Human Immune System" (HIS) mice and are a translational platform for studying human immune responses in vivo. Human HSC sources used in generating HIS mice include fetal liver (FL), umbilical cord blood (CB), and adu...

journal_title：Stem cells and development

authors： Walker JA,Vuyyuru R,Manser T,Alugupalli KR

更新日期：2017-12-01 00:00:00