Use of fluorescence in situ hybridization to detect minimal residual disease in hematopoietic stem cell assays from peripheral blood stem cells of 2 patients with trisomy 8 acute myeloid leukemia.

abstract：:Smooth muscle cell (SMC) differentiation and dedifferentiation play a critical role in the pathogenesis of cardiovascular diseases. The lack of a good and simple in vitro SMC differentiation system has hampered the progress of SMC field for years. The generation of such an in vitro system would be invaluable for explo...

journal_title：Stem cells and development

authors： Xie CQ,Huang H,Wei S,Song LS,Zhang J,Ritchie RP,Chen L,Zhang M,Chen YE

更新日期：2009-06-01 00:00:00

abstract：:Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demo...

journal_title：Stem cells and development

authors： Christensen C,Zhang S,Roelink H

更新日期：2006-10-01 00:00:00

abstract：:Multipotent skin-derived progenitors (SKPs) can be traced back to embryonic neural crest cells and are able to differentiate into both neural and mesodermal progeny in vitro. Neural stem cells (NSCs) are capable of self-renewing and can contribute to neuron and glia in the nervous system. Recently, we derived porcine ...

journal_title：Stem cells and development

authors： Zhao MT,Yang X,Lee K,Mao J,Teson JM,Whitworth KM,Samuel MS,Spate LD,Murphy CN,Prather RS

更新日期：2012-09-20 00:00:00

abstract：:In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. CD3(+) cells were separated by direct antibody-coupled magnetic beads, followed by DNA extraction according to a stan...

journal_title：Stem cells and development

authors： Uzunel M,Sairafi D,Remberger M,Mattsson J,Uhlin M

更新日期：2014-07-15 00:00:00

abstract：:Differential staining is an immunocytochemical staining that visualizes trophectoderm (TE) and the inner cell mass (ICM) of the blastocysts. It is used to determine the blastocyst quality, but could also be a useful tool to assess the integration site of injected cells into the early embryo. This is relevant for testi...

journal_title：Stem cells and development

authors： Secher JO,Freude KK,Li R,Callesen H

更新日期：2015-05-01 00:00:00

abstract：:In the central nervous system (CNS), generation of phenotypic diversity within the neuronal lineage is precisely regulated in a spatial and temporal fashion. Neural basic helix-loop-helix (bHLH) transcription factors are cell intrinsic factors that control commitment to neuronal lineage and play an important role in n...

journal_title：Stem cells and development

authors： Kumar M,Bagchi B,Gupta SK,Meena AS,Gressens P,Mani S

更新日期：2007-08-01 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) show great potential for clinical and experimental use due to their capacity to self-renew and differentiate into multiple mesenchymal lineages. However, disadvantages of primary cultures of hMSCs are the limited in vitro lifespan, and the variable properties of cells from diffe...

journal_title：Stem cells and development

authors： Skårn M,Noordhuis P,Wang MY,Veuger M,Kresse SH,Egeland EV,Micci F,Namløs HM,Håkelien AM,Olafsrud SM,Lorenz S,Haraldsen G,Kvalheim G,Meza-Zepeda LA,Myklebost O

更新日期：2014-10-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to a cascade of secondary chemical insults, including oxidative stress and glutamate excitotoxicity, which damage host neurons and glia. Transplantation of exogenous neural stem/progenitor cells (NSPCs) has shown promise in enhancing regeneration after SCI, although survival of...

journal_title：Stem cells and development

authors： Hachem LD,Mothe AJ,Tator CH

更新日期：2016-08-15 00:00:00

abstract：:Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy for repair of the diseased/injured central nervous system (CNS); however, controlling their differentiation remains a significant hurdle. This study is aimed at controlling differentiation and specifically at screening exogenous factors to...

journal_title：Stem cells and development

authors： Zahir T,Chen YF,MacDonald JF,Leipzig N,Tator CH,Shoichet MS

更新日期：2009-12-01 00:00:00

abstract：:Cell replacement therapy holds great promise for treating a wide range of human disorders. However, ensuring the predictable differentiation of transplanted stem cells, eliminating their risk of tumor formation, and generating fully functional cells after transplantation remain major challenges in regenerative medicin...

journal_title：Stem cells and development

authors： König N,Åkesson E,Telorack M,Vasylovska S,Ngamjariyawat A,Sundström E,Oster A,Trolle C,Berens C,Aldskogius H,Seiger Å,Kozlova EN

更新日期：2011-11-01 00:00:00

abstract：:Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC...

journal_title：Stem cells and development

authors： Knorr DA,Bock A,Brentjens RJ,Kaufman DS

更新日期：2013-07-01 00:00:00

abstract：:Adipose tissue (AT) is composed of mature adipocytes and stromal vascular fraction (SVF) cells, including adipose stem/stromal cells (ASCs). We characterized hematopoietic cells residing in human nonobese AT by analyzing the SVF isolated from human lipoaspirates and peripheral blood (PB). Flow cytometry revealed that ...

journal_title：Stem cells and development

authors： Eto H,Ishimine H,Kinoshita K,Watanabe-Susaki K,Kato H,Doi K,Kuno S,Kurisaki A,Yoshimura K

更新日期：2013-03-15 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Lymphedema is a medically irreversible condition for which currently conservative and surgical therapies are either ineffective or impractical. The potential use of progenitor and stem cell-based therapies has offered a paradigm that may provide alternative treatment options for lymphatic disorders. Moreover, basic re...

journal_title：Stem cells and development

authors： Qi S,Pan J

更新日期：2015-02-01 00:00:00

abstract：:To understand which growth factors/cytokines can affect migration of mesenchymal stem cells (MSCs) to injured tissues, we compared the effects of many (26) growth factors/cytokines on the migration activity of rabbit and human MSCs using a microchemotaxis chamber. Among them, platelet-derived growth factor (PDGF)-BB, ...

journal_title：Stem cells and development

authors： Ozaki Y,Nishimura M,Sekiya K,Suehiro F,Kanawa M,Nikawa H,Hamada T,Kato Y

更新日期：2007-02-01 00:00:00

abstract：:Lifelong neurogenesis in the mouse olfactory epithelium (OE) is regulated by the response of stem/progenitor cells to local signals, but embryonic and adult OE progenitors appear to be quite different--with potentially different mechanisms of regulation. A recently identified progenitor unique to embryonic OE--the nes...

journal_title：Stem cells and development

authors： Murdoch B,Roskams AJ

更新日期：2013-02-15 00:00:00

abstract：:Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, which is marked by decreased expression of Nanog and increased expression of neural stem cell marker N...

journal_title：Stem cells and development

authors： Tan Y,Xie Z,Ding M,Wang Z,Yu Q,Meng L,Zhu H,Huang X,Yu L,Meng X,Chen Y

更新日期：2010-09-01 00:00:00

abstract：:Diseases of the digestive tract are complex and encompass a broad spectrum of different pathogeneses (inflammatory, ischemic, neoplastic, and functional deficit). The digestive tract is not a sterile environment, and its organs are composed of tissues with different embryologic origin and different morphologic and fun...

journal_title：Stem cells and development

authors： Trebol Lopez J,Georgiev Hristov T,García-Arranz M,García-Olmo D

更新日期：2011-07-01 00:00:00

abstract：:Novel cell-based and gene therapies represent promising approaches for the treatment of incurable diseases, including cancer. Following the success of the hematopoietic stem cell-based transplantation, other populations of adult progenitor cells, including mesenchymal stem cells (MSCs), have been identified as powerfu...

journal_title：Stem cells and development

authors： Ciavarella S,Dominici M,Dammacco F,Silvestris F

更新日期：2011-01-01 00:00:00

abstract：:The quality of hematopoietic stem cells (HSCs) is essentially defined by two characteristics, i.e., multilineage differentiation and self-renewal capacity. Thus, it is of high priority to clarify mechanisms that regulate these functions and to understand them at the molecular level. In the present study, we investigat...

journal_title：Stem cells and development

authors： Schraml E,Voglauer R,Fortschegger K,Sibilia M,Stelzer I,Grillari J,Schauenstein K

更新日期：2008-04-01 00:00:00

abstract：:Death ligands and their tumor necrosis factor receptor (TNFR) family receptors are the best-characterized and most efficient inducers of apoptotic signaling in somatic cells. In this study, we analyzed whether these prototypic activators of apoptosis are also expressed and able to be activated in human pluripotent ste...

journal_title：Stem cells and development

authors： Vinarsky V,Krivanek J,Rankel L,Nahacka Z,Barta T,Jaros J,Andera L,Hampl A

更新日期：2013-11-15 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating medical condition with profound social and economic impacts. Although research is ongoing, current treatment options are limited and do little to restore functionality. However, recent studies suggest that mesenchymal stem cell-derived exosomes (MSC-exosomes) may hold the key ...

journal_title：Stem cells and development

authors： Ren Z,Qi Y,Sun S,Tao Y,Shi R

更新日期：2020-12-01 00:00:00

abstract：:Allergic asthma is an inflammatory airway disease caused by T helper type 2 (Th2)-driven immune responses. Recent studies have demonstrated that adipose-derived stromal cells (ASC) have an immunosuppressive effect on T-cell activity. This study was performed to investigate whether ASC can inhibit Th2-dependent allergi...

journal_title：Stem cells and development

authors： Park HK,Cho KS,Park HY,Shin DH,Kim YK,Jung JS,Park SK,Roh HJ

更新日期：2010-11-01 00:00:00

abstract：:In recent years it has been hypothesized that cancer stem cells (CSCs) are the actual driving force of tumor formation, highlighting the need to specifically target CSCs to successfully eradicate cancer growth and recurrence. Particularly, the deregulation of physiological signaling pathways controlling stem cell prol...

journal_title：Stem cells and development

authors： Persano L,Zagoura D,Louisse J,Pistollato F

更新日期：2015-10-15 00:00:00

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00

abstract：:Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic printing. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using chromatin immunoprecipitation (ChIP)-polymerase chain reaction and ChI...

journal_title：Stem cells and development

authors： Leschik J,Caron L,Yang H,Cowan C,Pucéat M

更新日期：2015-02-01 00:00:00

abstract：:The peritoneum mesothelium lines body cavities and has the same origin as ovarian surface epithelium with probable existence of peritoneum mesenchymal stem cells (PMSCs). In the present research, PMSCs were isolated from peritoneum and differentiated into ovarian cell-like cells using human follicular fluid (HFF) and ...

journal_title：Stem cells and development

authors： Mirzaeian L,Eftekhari-Yazdi P,Esfandiari F,Eivazkhani F,Rezazadeh Valojerdi M,Moini A,Fathi R

更新日期：2019-04-15 00:00:00

abstract：:In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and their effects in a peripheral nerve injury model were determined. In vitro growth factor stimulation of the cells resulted in increased s...

journal_title：Stem cells and development

authors： Kingham PJ,Kolar MK,Novikova LN,Novikov LN,Wiberg M

更新日期：2014-04-01 00:00:00

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00