Growth factor preconditioning increases the function of diabetes-impaired mesenchymal stem cells.

abstract：:Tumor necrosis factor-α (TNF-α) has multiple effects on proliferation and differentiation of human mesenchymal stem cells. Transforming growth factor-activated kinase-1 (TAK1) mediates the activation of nuclear factor-kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways in response to TNF-α. However, the r...

journal_title：Stem cells and development

authors： Lee SY,Lee JH,Shin KK,Kim DS,Kim YS,Bae YC,Jung JS

更新日期：2015-04-01 00:00:00

abstract：:Regenerative medicine, a paragon of future healthcare, holds unprecedented potential in extending the reach of treatment modalities for individuals across diseases and lifespan. Emerging regenerative technologies, focused on structural repair and functional restoration, signal a radical transformation in medical and s...

journal_title：Stem cells and development

authors： Terzic A,Harper CM Jr,Gores GJ,Pfenning MA

更新日期：2013-12-01 00:00:00

abstract：:Studies on rodent bone marrow stromal cells (MSCs) have revealed a capacity, for at least a portion of cells, to express neuron-like traits after differentiation in culture. Little, however, is known about the ability of human MSCs in this regard. We show here that incubation with certain differentiation cocktails, pa...

journal_title：Stem cells and development

authors： Suon S,Jin H,Donaldson AE,Caterson EJ,Tuan RS,Deschennes G,Marshall C,Iacovitti L

更新日期：2004-12-01 00:00:00

abstract：:Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic...

journal_title：Stem cells and development

authors： Helm A,Arrizabalaga O,Pignalosa D,Schroeder IS,Durante M,Ritter S

更新日期：2016-01-15 00:00:00

abstract：:The hedgehog (Hh) signaling pathway plays fundamental roles during embryonic development and tumorigenesis. Previously, we have shown that ablation of the tumor suppressor and negative regulator, Suppressor of fused (Sufu), within this pathway causes embryonic lethality around E9.5 in the mouse. In this study, we exam...

journal_title：Stem cells and development

authors： Hoelzl MA,Heby-Henricson K,Bilousova G,Rozell B,Kuiper RV,Kasper M,Toftgård R,Teglund S

更新日期：2015-11-01 00:00:00

abstract：:Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the developing fetus, and may represent a novel source of stem cells for cell therapy. In this study, we examined the paracrine factors released by human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) and their ability to...

journal_title：Stem cells and development

authors： Yoon BS,Moon JH,Jun EK,Kim J,Maeng I,Kim JS,Lee JH,Baik CS,Kim A,Cho KS,Lee JH,Lee HH,Whang KY,You S

更新日期：2010-06-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities that enhances the efficacy of TRAIL in glioma is much sought after. In ...

journal_title：Stem cells and development

authors： Yulyana Y,Endaya BB,Ng WH,Guo CM,Hui KM,Lam PY,Ho IA

更新日期：2013-07-01 00:00:00

abstract：:The chemokine stromal cell-derived factor (SDF)-1α/CXCL12 and its receptor CXC chemokine receptor 4 (CXCR4) play a crucial role in the homing/engraftment and retention of hematopoietic stem/progenitor cells (HSPCs) in the bone marrow. It has been shown using the viral gene transfer technique that CXCR4 overexpression ...

journal_title：Stem cells and development

authors： Gul-Uludag H,Xu P,Marquez-Curtis LA,Xing J,Janowska-Wieczorek A,Chen J

更新日期：2012-07-01 00:00:00

abstract：:With the recent advances in regenerative medicine, nanotechnology has created a niche for itself as a promising avenue in this field. Innumerable studies have been carried out by researchers using virus-based methodologies for the purpose of epigenetic reprogramming. Although this method is ostensibly safe, nonetheles...

journal_title：Stem cells and development

authors： Kadengodlu PA,Rai VR

更新日期：2015-03-01 00:00:00

abstract：:A common observation in metabolic disorders and aging is the elevation of free fatty acids, which can form ectopic fat deposition and result in lipotoxicity. Ectopic fat deposition of skeletal muscle has been recognized as an important component of aging, frailty and sarcopenia. Previous studies have suggested that li...

journal_title：Stem cells and development

authors： Xue M,Zhang F,Ji X,Yu H,Jiang X,Qiu Y,Yu J,Chen J,Yang F,Bao Z

更新日期：2021-01-11 00:00:00

abstract：:Transplantation of retinal cells has recently provided a promising therapeutic approach for retinal degeneration. Here, we differentiated initially retinal progenitors (RPs) from adherent feeder-free human embryonic stem cells (hESCs) with the use of defined media supplemented with a specific combination of growth fac...

journal_title：Stem cells and development

authors： Amirpour N,Karamali F,Rabiee F,Rezaei L,Esfandiari E,Razavi S,Dehghani A,Razmju H,Nasr-Esfahani MH,Baharvand H

更新日期：2012-01-01 00:00:00

abstract：:Liver transplantation is the only radical treatment for decompensated cirrhosis, but its use is limited owing to a shortage of donors; hence, there is an urgent need for new treatments. Previously, we developed a liver-regeneration therapy using autologous bone marrow-derived mesenchymal stem cells (BMSCs), which is u...

journal_title：Stem cells and development

authors： Nishi M,Matsumoto T,Fujisawa K,Suehiro Y,Takami T,Yamamoto N,Yamasaki T,Sakaida I

更新日期：2020-11-15 00:00:00

abstract：:Expression of the transcription factor Snail is required for normal vasculogenesis in the developing mouse embryo. In addition, tumors expressing Snail have been associated with a more malignant phenotype, with both increased invasive properties and angiogenesis. Although the relationship between Snail and vasculogene...

journal_title：Stem cells and development

authors： Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Murphy KM

更新日期：2012-01-20 00:00:00

abstract：:Administration of human bone marrow-derived mesenchymal stem cells (BM-MSCs) significantly alleviates allergic airway inflammation. There are no studies that refer to the role of microRNAs (miRNAs) after the BM-MSCs treatment in airway allergic inflammation. We induced a mouse model of asthma and performed the transpl...

journal_title：Stem cells and development

authors： Tang GN,Li CL,Yao Y,Xu ZB,Deng MX,Wang SY,Sun YQ,Shi JB,Fu QL

更新日期：2016-06-15 00:00:00

abstract：:Lymphedema is a medically irreversible condition for which currently conservative and surgical therapies are either ineffective or impractical. The potential use of progenitor and stem cell-based therapies has offered a paradigm that may provide alternative treatment options for lymphatic disorders. Moreover, basic re...

journal_title：Stem cells and development

authors： Qi S,Pan J

更新日期：2015-02-01 00:00:00

abstract：:The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. Th...

journal_title：Stem cells and development

authors： Xie Y,Awonuga A,Liu J,Rings E,Puscheck EE,Rappolee DA

更新日期：2013-05-15 00:00:00

abstract：:The development of methods to induce differentiation of human mesenchymal stem cells (hMSCs) has opened the possibility of using these cells in regenerative or reparative therapies. However, the low frequency of hMSCs in tissue means it is often necessary to expand these cells extensively in vitro. In this study, we e...

journal_title：Stem cells and development

authors： Khoo ML,Shen B,Tao H,Ma DD

更新日期：2008-10-01 00:00:00

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00

abstract：:In recent years it has been hypothesized that cancer stem cells (CSCs) are the actual driving force of tumor formation, highlighting the need to specifically target CSCs to successfully eradicate cancer growth and recurrence. Particularly, the deregulation of physiological signaling pathways controlling stem cell prol...

journal_title：Stem cells and development

authors： Persano L,Zagoura D,Louisse J,Pistollato F

更新日期：2015-10-15 00:00:00

abstract：:Embryonic stem cell (ESC) research gave rise to the possibility that stem cell therapy could be used in the treatment of incurable diseases such as neurodegenerative disorders. However, problems related to the tumorigenicity of undifferentiated ESCs must be resolved before such cells can be used in the application of ...

journal_title：Stem cells and development

authors： Park KD,Seong SK,Park YM,Choi Y,Park JH,Lee SH,Baek DH,Kang JW,Choi KS,Park SN,Kim DS,Kim SH,Kim HS

更新日期：2011-01-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after es...

journal_title：Stem cells and development

authors： O'Reilly M,Möbius MA,Vadivel A,Ionescu L,Fung M,Eaton F,Greer JJ,Thébaud B

更新日期：2020-03-15 00:00:00

abstract：:Embryonic stem (ES) cells are recognized as an excellent cell culture model for studying developmental mechanisms and their therapeutic modulations. The aim of this work was to define whether using magnetofection was an efficient way to manipulate stem cells genetically without adversely affecting their proliferation ...

journal_title：Stem cells and development

authors： Lee CH,Kim EY,Jeon K,Tae JC,Lee KS,Kim YO,Jeong MY,Yun CW,Jeong DK,Cho SK,Kim JH,Lee HY,Riu KZ,Cho SG,Park SP

更新日期：2008-02-01 00:00:00

abstract：:CD41 (αIIb integrin), a specific marker for megakaryocytes and platelets, was recently shown to mark the initiation of definitive hematopoiesis in mouse embryos. However, whether embryonic CD41(+) populations have a nonhematopoietic potential remains elusive. Here, we report that the CD41(+) cells from the mouse E11.0...

journal_title：Stem cells and development

authors： Zhou J,Chen H,Li S,Xie Y,He W,Nan X,Yue W,Liu B,Pei X

更新日期：2012-09-20 00:00:00

abstract：:Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we analyzed in this randomized, controlled study the influence of intracoronary autologous freshly isolated bone marrow cell...

journal_title：Stem cells and development

authors： Turan RG,Bozdag-Turan I,Ortak J,Akin I,Kische S,Schneider H,Turan CH,Rehders TC,Rauchhaus M,Kleinfeldt T,Adolph E,Brehm M,Yokus S,Steiner S,Sahin K,Nienaber CA,Ince H

更新日期：2011-09-01 00:00:00

abstract：:Protein tyrosine phosphatases have been recognized as critical components of multiple signaling regulators of fundamental cellular processes, including differentiation, cell death, and migration. In this study, we show that dual specificity phosphatase 4 (DUSP4) is crucial for neuronal differentiation and functions in...

journal_title：Stem cells and development

authors： Kim SY,Han YM,Oh M,Kim WK,Oh KJ,Lee SC,Bae KH,Han BS

更新日期：2015-03-15 00:00:00

abstract：:Placental abnormalities can cause Pregnancy-Associated Disorders, including preeclampsia, intrauterine growth restriction, and placental insufficiency, resulting in complications for both the mother and fetus. Trophoblast cells within the labyrinthine layer of the placenta facilitate the exchange of nutrients, gases, ...

journal_title：Stem cells and development

authors： Waker CA,Albers RE,Pye RL,Doliboa SR,Wyatt CN,Brown TL,Mayes DA

更新日期：2017-06-01 00:00:00

abstract：:Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demo...

journal_title：Stem cells and development

authors： Christensen C,Zhang S,Roelink H

更新日期：2006-10-01 00:00:00

abstract：:The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a complex process that involves significant epigenetic alterations in the reprogrammed cells. Epigenetic modifiers such as histone deacetylase (HDAC) inhibitors have been shown to increase the efficiency of derivation of iPSCs in humans an...

journal_title：Stem cells and development

authors： Petkov S,Glage S,Nowak-Imialek M,Niemann H

更新日期：2016-03-01 00:00:00

abstract：:Previous studies have transplanted a variety of neural stem cells (NSCs) to the eye in hopes of developing a therapy to replace retinal neurons lost to disease. Successful integration, survival, and differentiation of the cell types has been variably successful. At the moment, little is known about the fundamental bio...

journal_title：Stem cells and development

authors： Dunn-Thomas TE,Dobbs DL,Sakaguchi DS,Young MJ,Honovar VG,Greenlee MH

更新日期：2008-02-01 00:00:00

abstract：:Red blood cell (RBC) differentiation from human induced pluripotent stem cells (hiPSCs) offers great potential for developmental studies and innovative therapies. However, ex vivo erythropoiesis from hiPSCs is currently limited by low efficiency and unphysiological conditions of common culture systems. Especially, the...

journal_title：Stem cells and development

authors： Bernecker C,Ackermann M,Lachmann N,Rohrhofer L,Zaehres H,Araúzo-Bravo MJ,van den Akker E,Schlenke P,Dorn I

更新日期：2019-12-01 00:00:00