Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors.

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to a cascade of secondary chemical insults, including oxidative stress and glutamate excitotoxicity, which damage host neurons and glia. Transplantation of exogenous neural stem/progenitor cells (NSPCs) has shown promise in enhancing regeneration after SCI, although survival of...

journal_title：Stem cells and development

authors： Hachem LD,Mothe AJ,Tator CH

更新日期：2016-08-15 00:00:00

abstract：:There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hype...

journal_title：Stem cells and development

authors： Aliotta JM,Keaney PJ,Warburton RR,DelTatto M,Dooner MS,Passero MA,Quesenberry PJ,Klinger JR

更新日期：2009-06-01 00:00:00

abstract：:Cell replacement therapy holds great promise for treating a wide range of human disorders. However, ensuring the predictable differentiation of transplanted stem cells, eliminating their risk of tumor formation, and generating fully functional cells after transplantation remain major challenges in regenerative medicin...

journal_title：Stem cells and development

authors： König N,Åkesson E,Telorack M,Vasylovska S,Ngamjariyawat A,Sundström E,Oster A,Trolle C,Berens C,Aldskogius H,Seiger Å,Kozlova EN

更新日期：2011-11-01 00:00:00

abstract：:Special features of mesenchymal stem cells (MSCs) have made them a popular tool in cell therapy and tissue engineering. Although mouse animal models and murine MSCs are common tools in this field, our understanding of the effect of in vitro expansion on the behavior of these cells is poor and controversial. In additio...

journal_title：Stem cells and development

authors： Ahmadbeigi N,Soleimani M,Gheisari Y,Vasei M,Amanpour S,Bagherizadeh I,Shariati SA,Azadmanesh K,Amini S,Shafiee A,Arabkari V,Nardi NB

更新日期：2011-08-01 00:00:00

abstract：:The secretome of human amniotic fluid stem cells (AFSCs) has great potential as a therapeutic agent in regenerative medicine. However, it must be produced in a clinically compliant manner before it can be used in humans. In this study, we developed a means of producing a biologically active secretome from AFSCs that i...

journal_title：Stem cells and development

authors： Mellows B,Mitchell R,Antonioli M,Kretz O,Chambers D,Zeuner MT,Denecke B,Musante L,Ramachandra DL,Debacq-Chainiaux F,Holthofer H,Joch B,Ray S,Widera D,David AL,Huber TB,Dengjel J,De Coppi P,Patel K

更新日期：2017-09-15 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) was used to analyze peripheral blood stem cells (PBSC) and stem cell assays (SCA) derived from them in 2 patients with acute myeloid leukemia (AML) with trisomy 8 as the sole chromosome abnormality prior to undergoing autologous stem cell transplantation. In both cases, the de...

journal_title：Stem cells and development

authors： Dodge W,Cruz J,Zamkoff K,Hurd D,Pettenati MJ

更新日期：2004-02-01 00:00:00

abstract：:Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by defined factors. However, substantial cell numbers subjected to iPSC induction stray from the main reprogramming route and are immortalized as partial iPSCs. These partial iPSCs can become genuine iPSCs by exposure to the ground state condi...

journal_title：Stem cells and development

authors： Kamon M,Katano M,Hiraki-Kamon K,Hishida T,Nakachi Y,Mizuno Y,Okazaki Y,Suzuki A,Hirasaki M,Ueda A,Nishimoto M,Kato H,Okuda A

更新日期：2014-09-15 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Adipose tissue (AT) is composed of mature adipocytes and stromal vascular fraction (SVF) cells, including adipose stem/stromal cells (ASCs). We characterized hematopoietic cells residing in human nonobese AT by analyzing the SVF isolated from human lipoaspirates and peripheral blood (PB). Flow cytometry revealed that ...

journal_title：Stem cells and development

authors： Eto H,Ishimine H,Kinoshita K,Watanabe-Susaki K,Kato H,Doi K,Kuno S,Kurisaki A,Yoshimura K

更新日期：2013-03-15 00:00:00

abstract：:Embryonic stem-like (ES-like) cells have now been derived from the inner cell mass (ICM) of horse embryos at the blastocyst stage. Because they have been shown to express cell-surface antigens found in both human and mouse ES cells, the present study investigated gene expression patterns in day-7 horse blastocysts fro...

journal_title：Stem cells and development

authors： Guest DJ,Allen WR

更新日期：2007-10-01 00:00:00

abstract：:White matter damage persists in hypoxic-ischemic newborns even when treated with hypothermia. We have previously shown that intraventricular delivery of human glial progenitors (GPs) at the neonatal stage is capable of replacing abnormal host glia and rescuing the lifespan of dysmyelinated mice. However, such transpla...

journal_title：Stem cells and development

authors： Srivastava RK,Jablonska A,Chu C,Gregg L,Bulte JWM,Koehler RC,Walczak P,Janowski M

更新日期：2019-04-15 00:00:00

abstract：:Studies on rodent bone marrow stromal cells (MSCs) have revealed a capacity, for at least a portion of cells, to express neuron-like traits after differentiation in culture. Little, however, is known about the ability of human MSCs in this regard. We show here that incubation with certain differentiation cocktails, pa...

journal_title：Stem cells and development

authors： Suon S,Jin H,Donaldson AE,Caterson EJ,Tuan RS,Deschennes G,Marshall C,Iacovitti L

更新日期：2004-12-01 00:00:00

abstract：:This study was undertaken to establish rat embryonic stem (ES) cells from parthenogenetically developing blastocysts. Ten blastocysts were prepared by treatment of ovulated rat oocytes with ionomycin and cycloheximide, and three alkaline phosphatase-positive ES cell lines were established using the N2B27 medium supple...

journal_title：Stem cells and development

authors： Hirabayashi M,Goto T,Tamura C,Sanbo M,Hara H,Kato-Itoh M,Sato H,Kobayashi T,Nakauchi H,Hochi S

更新日期：2014-01-15 00:00:00

abstract：:Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew without differentiation. Although hES cells can be differentiated to many different tissue types in vitro, clinical uses have not yet been realized from the study of hES cells. Anticipation that these cells would be immediately us...

journal_title：Stem cells and development

authors： Bodnar MS,Meneses JJ,Rodriguez RT,Firpo MT

更新日期：2004-06-01 00:00:00

abstract：:How hematopoietic stem cells (HSCs) maintain the balance of self-renewal and differentiation could be partially ascribed to asymmetric and symmetric division patterns. However, a simple and effective method to detect stem cell division patterns is lacking. In this study, we introduce a strategy to describe stem cells ...

journal_title：Stem cells and development

authors： Yang WZ,Yu WY,Chen T,Wang XF,Dong F,Xie ME,Gong YM,Liang HY,Fu WC

更新日期：2019-07-15 00:00:00

abstract：:Here, we describe a focused microarray for screening rat embryonic stem cells (ESCs) and provide validation data that this array can distinguish undifferentiated rat ESCs from rat trophoblast stem (TS) cells, rat extraembryonic endoderm cells, mouse embryonic fibroblast feeder cells, and differentiated rat ESCs. Using...

journal_title：Stem cells and development

authors： Hong J,He H,Bui P,Ryba-White B,Rumi MA,Soares MJ,Dutta D,Paul S,Kawamata M,Ochiya T,Ying QL,Rajanahalli P,Weiss ML

更新日期：2013-02-01 00:00:00

abstract：:Periodontitis is an infectious disease characterized by chronic inflammation and progressive destruction of periodontal tissues. Chronic inflammatory environment may affect immunomodulatory function of periodontal ligament stem cells (PDLSCs) and promote shift toward proinflammatory phenotype contributing to propagati...

journal_title：Stem cells and development

authors： Čebatariūnienė A,Kriaučiūnaitė K,Prunskaitė J,Tunaitis V,Pivoriūnas A

更新日期：2019-08-01 00:00:00

abstract：:Regenerating islet (Reg) proteins are involved in the proliferation and differentiation of diverse cell types. However, whether embryonic stem cells (ESCs) express Reg genes and their corresponding proteins remains unknown. In this study, we probed the expression of Reg family members by mouse ESCs (mESCs). Mouse Reg1...

journal_title：Stem cells and development

authors： Jing D,Kehoe DE,Tzanakakis ES

更新日期：2010-09-01 00:00:00

abstract：:Human stem cells from various sources have potential therapeutic applications. The clinical implementation of these therapies introduces the need for methods of noninvasive tracking of cells. The purpose of this study was to evaluate a high resolution magnetic resonance imaging (MRI) technique for in vivo detection an...

journal_title：Stem cells and development

authors： Delo DM,Olson J,Baptista PM,D'Agostino RB Jr,Atala A,Zhu JM,Soker S

更新日期：2008-12-01 00:00:00

abstract：:Pericytes play a crucial role in angiogenesis and vascular maintenance. They can be readily identified in vivo and isolated as CD146(+)CD34(-) cells from various tissues. Whether these and other markers reliably identify pericytes in vitro is unclear. CD146(+)CD34(-) selected cells exhibit multilineage potential. Thus...

journal_title：Stem cells and development

authors： Blocki A,Wang Y,Koch M,Peh P,Beyer S,Law P,Hui J,Raghunath M

更新日期：2013-09-01 00:00:00

abstract：:In the central nervous system (CNS), generation of phenotypic diversity within the neuronal lineage is precisely regulated in a spatial and temporal fashion. Neural basic helix-loop-helix (bHLH) transcription factors are cell intrinsic factors that control commitment to neuronal lineage and play an important role in n...

journal_title：Stem cells and development

authors： Kumar M,Bagchi B,Gupta SK,Meena AS,Gressens P,Mani S

更新日期：2007-08-01 00:00:00

abstract：:To develop biological approaches to restore vision, we developed a method of transplanting stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat). Human embryonic stem cells (hESC) were differentiated to retinal organoids in a dish. hESC-derived retinal tissue was introduced into ...

journal_title：Stem cells and development

authors： Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO

更新日期：2019-09-01 00:00:00

abstract：:Dental follicle stem cells (DFSCs), which are the stem cells present in the dental follicle tissue of the tooth germ and are derived from the neural crest, are direct precursor cells of periodontal tissues and can form the periodontal ligament, cementum, and alveolar bone proper in the late stage of tooth development....

journal_title：Stem cells and development

authors： Zhang J,Ding H,Liu X,Sheng Y,Liu X,Jiang C

更新日期：2019-08-01 00:00:00

abstract：:Over the past 20 months, reports claiming the generation of induced pluripotent stem (iPS) cells with characteristics identical to those of embryonic stem (ES) cells from nonembryonic tissue have captured great attention in both the scientific community and the general public. In the light of the continuing controvers...

journal_title：Stem cells and development

authors： Liu SV

更新日期：2008-06-01 00:00:00

abstract：:Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long culture history. Several mechanisms were described to account for this capability. Since several of the described mechanis...

journal_title：Stem cells and development

authors： van den Berk LC,Jansen BJ,Snowden S,Siebers-Vermeulen KG,Gilissen C,Kögler G,Figdor CG,Wheelock CE,Torensma R

更新日期：2014-07-15 00:00:00

abstract：:My concept of cell differentiation involves genetic information from DNA being transcribed into mRNA proteins-morphogenes (mRNAs+ homeodomain proteins)-and stored in the ovoplasm as maternal inheritance, or cytoplasmic genetic memory. Feedback mechanism(s) allow these morphogenes to selectively unlock new genes, regul...

journal_title：Stem cells and development

authors： Kristeva MA

更新日期：2008-10-01 00:00:00

abstract：:The mechanisms responsible for the inhibitory effects of mesenchymal stem cells (MSCs) on dendritic cells (DCs) are still poorly understood. Our investigation of the potential signaling pathways revealed for the first time that human umbilical-cord-derived MSCs (UC-MSCs) instruct DCs to acquire tolerogenic phenotypes ...

journal_title：Stem cells and development

authors： Deng Y,Yi S,Wang G,Cheng J,Zhang Y,Chen W,Tai Y,Chen S,Chen G,Liu W,Zhang Q,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous system, and induced pluripotent stem cells (iPSCs) are envisioned to b...

journal_title：Stem cells and development

authors： Umebayashi D,Coles B,van der Kooy D

更新日期：2016-05-01 00:00:00

abstract：:Accumulating evidence suggests that the delivery of human adipose tissue-derived stromal cells (hASCs) has great potential as regenerative therapy. This was performed to develop a method for expanding hASCs by reducing the amount of serum required. We demonstrate that hASCs were able to expand efficiently in media con...

journal_title：Stem cells and development

authors： Iwashima S,Ozaki T,Maruyama S,Saka Y,Kobori M,Omae K,Yamaguchi H,Niimi T,Toriyama K,Kamei Y,Torii S,Murohara T,Yuzawa Y,Kitagawa Y,Matsuo S

更新日期：2009-05-01 00:00:00