Malfunction in Mitochondrial β-Oxidation Contributes to Lipid Accumulation in Hepatocyte-Like Cells Derived from Citrin Deficiency-Induced Pluripotent Stem Cells.

abstract：:Chronic idiopathic neutropenia (CIN) is a granulopoiesis disorder associated with an inhibitory bone marrow (BM) microenvironment consisting of activated T-lymphocytes and pro-inflammatory mediators. In this study, we investigated the possible involvement of BM mesenchymal stem cells (MSCs) in the pathophysiology of C...

journal_title：Stem cells and development

authors： Stavroulaki E,Kastrinaki MC,Pontikoglou C,Eliopoulos D,Damianaki A,Mavroudi I,Pyrovolaki K,Katonis P,Papadaki HA

更新日期：2011-08-01 00:00:00

abstract：:Embryonic stem (ES) cells give rise to mesodermal progenitors that differentiate to hematopoietic and cardiovascular cells. The wnt signaling pathway plays multiple roles in cardiovascular development through a network of intracellular effectors. To monitor global changes in wnt signaling during ES cell differentiatio...

journal_title：Stem cells and development

authors： Rai M,Walthall JM,Hu J,Hatzopoulos AK

更新日期：2012-01-01 00:00:00

abstract：:Studies on rodent bone marrow stromal cells (MSCs) have revealed a capacity, for at least a portion of cells, to express neuron-like traits after differentiation in culture. Little, however, is known about the ability of human MSCs in this regard. We show here that incubation with certain differentiation cocktails, pa...

journal_title：Stem cells and development

authors： Suon S,Jin H,Donaldson AE,Caterson EJ,Tuan RS,Deschennes G,Marshall C,Iacovitti L

更新日期：2004-12-01 00:00:00

abstract：:Multipotent skin-derived progenitors (SKPs) can be traced back to embryonic neural crest cells and are able to differentiate into both neural and mesodermal progeny in vitro. Neural stem cells (NSCs) are capable of self-renewing and can contribute to neuron and glia in the nervous system. Recently, we derived porcine ...

journal_title：Stem cells and development

authors： Zhao MT,Yang X,Lee K,Mao J,Teson JM,Whitworth KM,Samuel MS,Spate LD,Murphy CN,Prather RS

更新日期：2012-09-20 00:00:00

abstract：:The major reservoir of human multipotent mesenchymal stem/stromal cells (MSCs) is the bone marrow (BM) with the capability to control hematopoietic stem cell development. The regenerative potential of MSCs is associated with enhanced endogenous repair and healing mechanisms that modulate inflammatory responses. Our pr...

journal_title：Stem cells and development

authors： Bacskai I,Mázló A,Kis-Tóth K,Szabó A,Panyi G,Sarkadi B,Apáti Á,Rajnavölgyi É

更新日期：2015-08-01 00:00:00

abstract：:Cell-based gene therapy holds a great promise for the treatment of human malignancy. Among different cells, mesenchymal stem cells (MSCs) are emerging as valuable anti-cancer agents that have the potential to be used to treat a number of different cancer types. They have inherent migratory properties, which allow them...

journal_title：Stem cells and development

authors： Nowakowski A,Drela K,Rozycka J,Janowski M,Lukomska B

更新日期：2016-10-01 00:00:00

abstract：:Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cel...

journal_title：Stem cells and development

authors： Barry FP,Murphy JM,English K,Mahon BP

更新日期：2005-06-01 00:00:00

abstract：:Stromal cells have been used to induce dopaminergic differentiation of mouse, primate, and human embryonic stem cells (hESCs), but the mechanism that governs this induction is unknown. In this manuscript, we show that medium conditioned by the stromal cell line PA6 (PA6-CM) can induce dopaminergic differentiation in n...

journal_title：Stem cells and development

authors： Swistowska AM,da Cruz AB,Han Y,Swistowski A,Liu Y,Shin S,Zhan M,Rao MS,Zeng X

更新日期：2010-01-01 00:00:00

abstract：:The paired type homeobox 6 (Pax6) transcription factor (TF) regulates multiple aspects of neural stem cell (NSC) and neuron development in the embryonic central nervous system. However, less is known about the role of Pax6 in the maintenance and differentiation of adult NSCs and in adult neurogenesis. Using the +/Sey(...

journal_title：Stem cells and development

authors： Curto GG,Nieto-Estévez V,Hurtado-Chong A,Valero J,Gómez C,Alonso JR,Weruaga E,Vicario-Abejón C

更新日期：2014-12-01 00:00:00

abstract：:We have isolated a novel progenitor cell population from adult rat pancreatic ducts, termed pancreatic-derived progenitor cells (PDPCs). Here, we report the in vitro culture, selection, and characterization of Thy1.1-positive and Thy1.1-negative PDPC subpopulations. These cells exhibit bipotentiality for differentiati...

journal_title：Stem cells and development

authors： Stevenson KS,McGlynn L,Hodge M,McLinden H,George WD,Davies RW,Shiels PG

更新日期：2009-12-01 00:00:00

abstract：:After intra-articular injection, synovium-derived mesenchymal stem cells (SMSCs) can adhere to damaged cartilage (a process called homing) and then repair the cartilage defect. Nonetheless, the main obstacle of the current method is the insufficient homing ratio of SMSCs, which fails to meet the requirements for carti...

journal_title：Stem cells and development

authors： Liang C,Huang J,Luo P,Wang Z,He J,Wu S,Peng C,Cao X

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to clarify the mechanisms that regulate hematopoietic cell expansion in vitro by identifying defined culture conditions. We report the results of experiments with CD34(+) cells from cord blood (CB, n = 13), bone marrow (BM, n = 4), and mobilized peripheral blood stem cells (PBSC, n = 5) using...

journal_title：Stem cells and development

authors： Rossi B,Zanolin E,Vincenzi C,Diani F,Pizzolo G,de Wynter E,Nadali G

更新日期：2004-08-01 00:00:00

abstract：:Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is an extracellular matrix...

journal_title：Stem cells and development

authors： Ghazalli N,Mahdavi A,Feng T,Jin L,Kozlowski MT,Hsu J,Riggs AD,Tirrell DA,Ku HT

更新日期：2015-09-01 00:00:00

abstract：:Novel cell-based and gene therapies represent promising approaches for the treatment of incurable diseases, including cancer. Following the success of the hematopoietic stem cell-based transplantation, other populations of adult progenitor cells, including mesenchymal stem cells (MSCs), have been identified as powerfu...

journal_title：Stem cells and development

authors： Ciavarella S,Dominici M,Dammacco F,Silvestris F

更新日期：2011-01-01 00:00:00

abstract：:Myocardial infarction (MI) results in loss of myofibers in the ischemic zone of the heart, followed by scar formation. These factors increase barriers to mobilization of mesenchymal stem cells (MSC), thereby impeding their effectiveness in cardiac repair. This study examined MSC overexpressing CXCR4 (MSC(CX4)) to dete...

journal_title：Stem cells and development

authors： Huang W,Wang T,Zhang D,Zhao T,Dai B,Ashraf A,Wang X,Xu M,Millard RW,Fan GC,Ashraf M,Yu XY,Wang Y

更新日期：2012-03-20 00:00:00

abstract：:Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells wer...

journal_title：Stem cells and development

authors： Park BW,Pan B,Toms D,Huynh E,Byun JH,Lee YM,Shen W,Rho GJ,Li J

更新日期：2014-07-15 00:00:00

abstract：:Phenotypic guidance of embryonic stem (ES) cell fate is paramount if these cells are to be used for tissue repair and regeneration. Our objective was to compare two different cell culture feeders and their effect on proliferation, apoptosis, and differentiation of human (h) ES cells. HSF-6 hES cells were grown in Knoc...

journal_title：Stem cells and development

authors： Ozolek JA,Jane EP,Krowsoski L,Sammak PJ

更新日期：2007-06-01 00:00:00

abstract：:Uterine remodeling during pregnancy is a fundamental, dynamic process required for successful propagation of eutherian species. The uterus can increase in size up to 40-fold during pregnancy, which is largely attributed to expansion of the myometrium by hyperplasia and hypertrophy. After pregnancy, the uterus repairs ...

journal_title：Stem cells and development

authors： Patterson AL,George JW,Chatterjee A,Carpenter T,Wolfrum E,Pru JK,Teixeira JM

更新日期：2018-12-15 00:00:00

abstract：:Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, which is marked by decreased expression of Nanog and increased expression of neural stem cell marker N...

journal_title：Stem cells and development

authors： Tan Y,Xie Z,Ding M,Wang Z,Yu Q,Meng L,Zhu H,Huang X,Yu L,Meng X,Chen Y

更新日期：2010-09-01 00:00:00

abstract：:Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some SC types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess...

journal_title：Stem cells and development

authors： Di Trapani M,Bassi G,Ricciardi M,Fontana E,Bifari F,Pacelli L,Giacomello L,Pozzobon M,Féron F,De Coppi P,Anversa P,Fumagalli G,Decimo I,Menard C,Tarte K,Krampera M

更新日期：2013-11-15 00:00:00

abstract：:The placenta is a transient organ that develops upon the initiation of pregnancy and is essential for embryonic development and fetal survival. The rodent placenta consists of distinct lineages and includes cell types that are analogous to those that make up the human placenta. Trophoblast cells within the labyrinth l...

journal_title：Stem cells and development

authors： Carey EA,Albers RE,Doliboa SR,Hughes M,Wyatt CN,Natale DR,Brown TL

更新日期：2014-12-01 00:00:00

abstract：:Periodontitis is an infectious disease characterized by chronic inflammation and progressive destruction of periodontal tissues. Chronic inflammatory environment may affect immunomodulatory function of periodontal ligament stem cells (PDLSCs) and promote shift toward proinflammatory phenotype contributing to propagati...

journal_title：Stem cells and development

authors： Čebatariūnienė A,Kriaučiūnaitė K,Prunskaitė J,Tunaitis V,Pivoriūnas A

更新日期：2019-08-01 00:00:00

abstract：:Previous studies have transplanted a variety of neural stem cells (NSCs) to the eye in hopes of developing a therapy to replace retinal neurons lost to disease. Successful integration, survival, and differentiation of the cell types has been variably successful. At the moment, little is known about the fundamental bio...

journal_title：Stem cells and development

authors： Dunn-Thomas TE,Dobbs DL,Sakaguchi DS,Young MJ,Honovar VG,Greenlee MH

更新日期：2008-02-01 00:00:00

abstract：:In spina bifida, the neural tube fails to close during the embryonic period. Exposure of the neural tube to the amniotic fluid during pregnancy causes additional neural damage. Intrauterine tissue engineering using a biomaterial seeded with stem cells might prevent this additional damage. For this purpose, autologous ...

journal_title：Stem cells and development

authors： Hosper NA,Bank RA,van den Berg PP

更新日期：2014-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. In this study, we sh...

journal_title：Stem cells and development

authors： Liu X,Ren S,Ge C,Cheng K,Li X,Zhao RC

更新日期：2018-04-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities that enhances the efficacy of TRAIL in glioma is much sought after. In ...

journal_title：Stem cells and development

authors： Yulyana Y,Endaya BB,Ng WH,Guo CM,Hui KM,Lam PY,Ho IA

更新日期：2013-07-01 00:00:00

abstract：:Stem cell-based therapies have demonstrated great potential for the treatment of cardiac diseases, for example, myocardial infarction; however, low cell viability, low retention/engraftment, and uncontrollable in vivo differentiation after transplantation are still major limitations, which lead to low therapeutic effi...

journal_title：Stem cells and development

authors： Ledford BT,Simmons J,Chen M,Fan H,Barron C,Liu Z,Van Dyke M,He JQ

更新日期：2017-06-15 00:00:00

abstract：:The development of the heart is essential for embryogenesis and precedes development of other organs. However, the mechanisms involved in embryonic cardiac development are ill-defined. Recent evidence suggests that Smad and Wnt signaling pathways are important in stem cell fate determination and their commitment to ca...

journal_title：Stem cells and development

authors： Pal R,Khanna A

更新日期：2006-02-01 00:00:00

abstract：:Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...

journal_title：Stem cells and development

authors： Wu JH,Wang HJ,Tan YZ,Li ZH

更新日期：2012-05-20 00:00:00

abstract：:Aneurysm refers to the dilation of the vessel wall for more than 50%. Abdominal aortic aneurysm (AAA) refers to the dilation and weakening of all three layers of the abdominal aorta, which mostly occur infrarenally. The population aged above 50 years is at risk of AAA development, while a familiar history doubles the ...

journal_title：Stem cells and development

authors： Parvizi M,Harmsen MC

更新日期：2015-07-01 00:00:00