Abstract:
:We aimed to compare serum levels of the inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome (OSAS), and their coexistence called overlap syndrome (OVS). In addition, we planned to investigate changes of these mediators with the treatment of continuous positive airway pressure (CPAP) in OSAS and OVS. CRP, TNF-α, and ADMA levels were analyzed by ELISA method from blood samples withdrawn from patients with COPD (N = 25), OVS (N = 25), and moderate- to severe-stage OSAS (N = 25). First blood samples were taken in the morning after polysomnography application, and second blood samples were taken from OSAS and OVS patients who underwent regular CPAP treatment. In comparison of three groups prior to CPAP treatment, ADMA level in OSAS were significantly lower than in COPD (p = 0.009), but CRP and TNF-α were similar among groups. When we compared the parameters before and after CPAP treatment, the level of CRP in both OSAS and OVS decreased significantly (p = 0.02, p = 0.04), whereas TNF-α and ADMA levels did not display any significant differences. A decrease of serum CRP level in OVS and OSAS groups following effective CPAP treatment shows that CPAP is an effective treatment method for systemic inflammation.
journal_name
Inflammationjournal_title
Inflammationauthors
Nural S,Günay E,Halici B,Celik S,Ünlü Mdoi
10.1007/s10753-012-9520-zsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
66-74issue
1eissn
0360-3997issn
1573-2576journal_volume
36pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0149-6
更新日期:2015-08-01 00:00:00
abstract::Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01071-5
更新日期:2020-02-01 00:00:00
abstract::It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to developme...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9107-5
更新日期:2009-04-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000033020.28446.a6
更新日期:2004-04-01 00:00:00
abstract::We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9936-8
更新日期:2014-12-01 00:00:00
abstract::Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9154-y
更新日期:2010-02-01 00:00:00
abstract::The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0122-4
更新日期:2015-08-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe si...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0642-1
更新日期:2017-12-01 00:00:00
abstract::To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9084-0
更新日期:2008-10-01 00:00:00
abstract::Streptococcus suis serotype 2 (SS2) is an emerging zoonosis, and meningitis is the most frequent clinical manifestation, but mechanism of its virulent factor, enolase (Eno), is unknown in meningitis. In this study, Eno was inducibly expressed and added to an in vitro Transwell co-culture model of the blood-brain barri...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0298-7
更新日期:2016-04-01 00:00:00
abstract::Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914305
更新日期:1989-12-01 00:00:00
abstract::Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01154-3
更新日期:2020-04-01 00:00:00
abstract::Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellul...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027363730746
更新日期:1997-10-01 00:00:00
abstract::Crohn's disease is an idiopathic, chronic inflammation of the gastrointestinal tract that causes narrowing and stricturing of primarily the small and large intestine. Although the mechanism(s) by which chronic inflammation promotes stricture formation remain to be defined, it does appear to be associated histologicall...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916587
更新日期:1993-08-01 00:00:00
abstract::The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP)...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1016515712344
更新日期:2002-08-01 00:00:00
abstract::Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0619-0
更新日期:2017-10-01 00:00:00
abstract::The etiology of the most autoimmune disorders is largely yet to be understood. However, major target antigens have been determined against some of clinically important molecules of human autoimmune diseases, such as insulin in type 1 diabetes mellitus (T1DM). T1DM is believed to be resulted from immune-mediated destru...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-012-9555-1
更新日期:2013-04-01 00:00:00
abstract::The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at dos...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0699-x
更新日期:2018-03-01 00:00:00
abstract::Acute lung injury (ALI)/acute respiratory distress syndrome is characterized by increased pulmonary inflammation, where T helper 17 (Th17) cells play an important regulatory role. Notch signaling critically regulates Th17 differentiation and is known to be linked with proximal T cell by protein kinase C theta (PKCθ). ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01058-2
更新日期:2019-12-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract::In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918958
更新日期:1992-04-01 00:00:00
abstract::Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-011-9346-0
更新日期:2012-04-01 00:00:00
abstract::Different studies have shown the regulatory effects of vitamin D(3) on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-γ cyto...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9531-9
更新日期:2013-02-01 00:00:00
abstract::Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916396
更新日期:1988-04-01 00:00:00
abstract::Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01114-x
更新日期:2020-02-01 00:00:00
abstract::Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910714
更新日期:1982-03-01 00:00:00
abstract::Following publication of our article [1], we noticed an error in Fig. 1. ...
journal_title:Inflammation
pub_type: 已发布勘误
doi:10.1007/s10753-020-01380-0
更新日期:2020-11-10 00:00:00
abstract::The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534556
更新日期:1994-04-01 00:00:00