Abstract：
:Microglial activation and subsequent release of toxic pro-inflammatory factors are believed to play an important role in neuronal cell death associated with Parkinson's disease (PD). Compounds that inhibit microglia activation and suppress pro-inflammatory factor release have been reported to have neuroprotective effects in animal models of PD. In this study, we tested whether diadzein, a natural isoflavone found in soybean, attenuated lipopolysaccharide (LPS)-induced release of inflammatory mediators in BV-2, a murine microglial cell line. Diadzein pretreatment was found to significantly suppress the production of the pro-inflammatory factors nitric oxide and IL-6 as well as their mRNA expression in conjunction with reductions in ROS production, p38 MAPK phosphorylation, and NF-κB activation. Furthermore, transfer of conditioned media (CM) from BV-2 cells pretreated with diadzein resulted in a significantly reduction in dopaminergic neurotoxicity compared with CM from microglia stimulated with LPS alone. Together, our results suggest that diadzein's neuroprotective properties may be due to its ability to dampen induction of microglial activation and the subsequent release of soluble pro-inflammatory factors. This appears to be via inhibition of oxidative induction of the p38 MAP kinase-NFκB pathway, resulting in reduced expression of pro-inflammatory genes and release of their corresponding gene products.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Chinta SJ,Ganesan A,Reis-Rodrigues P,Lithgow GJ,Andersen JKdoi
10.1007/s12640-012-9328-5subject
Has Abstractpub_date
2013-02-01 00:00:00pages
145-53issue
2eissn
1029-8428issn
1476-3524journal_volume
23pub_type
杂志文章abstract：:The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00051-9
更新日期：2019-11-01 00:00:00
abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00055-5
更新日期：2019-11-01 00:00:00
abstract：:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00142-7
更新日期：2020-04-01 00:00:00
abstract：:Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033334
更新日期：2006-08-01 00:00:00
abstract：:Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9696-3
更新日期：2017-05-01 00:00:00
abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9874-6
更新日期：2018-04-01 00:00:00
abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9520-5
更新日期：2015-07-01 00:00:00
abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033301
更新日期：2004-01-01 00:00:00
abstract：:Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9800-3
更新日期：2018-02-01 00:00:00
abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00294-x
更新日期：2020-10-06 00:00:00
abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9652-2
更新日期：2016-11-01 00:00:00
abstract：:Mercury is a ubiquitous contaminant, and a range of chemical species is generated by human activity and natural environmental change. Elemental mercury and its inorganic and organic compounds have different toxic properties, but all them are considered hazardous in human exposure. In an equimolecular exposure basis, o...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033386
更新日期：2003-01-01 00:00:00
abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033804
更新日期：2008-10-01 00:00:00
abstract：:Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-010-9163-5
更新日期：2010-11-01 00:00:00
abstract：:Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00021-1
更新日期：2019-11-01 00:00:00
abstract：:Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00101-2
更新日期：2020-01-01 00:00:00
abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9824-8
更新日期：2018-04-01 00:00:00
abstract：:Effects of chemotherapeutics on glioma cell lines and spheroids are usually investigated without evaluating the effects of chemotherapeutics on normal brain tissue. To perform such investigations, the aim of this study was to establish a panel of markers for detection of general cell death and more specific neuronal a...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9300-9
更新日期：2012-07-01 00:00:00
abstract：:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9578-0
更新日期：2016-02-01 00:00:00
abstract：:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9754-5
更新日期：2017-10-01 00:00:00
abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9372-1
更新日期：2013-07-01 00:00:00
abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033166
更新日期：2003-01-01 00:00:00
abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033264
更新日期：2001-07-01 00:00:00
abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9321-z
更新日期：2013-01-01 00:00:00
abstract：:Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033437
更新日期：2004-01-01 00:00:00
abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9421-4
更新日期：2014-02-01 00:00:00
abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9054-9
更新日期：2009-10-01 00:00:00
abstract：:We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00064-4
更新日期：2019-10-01 00:00:00
abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033901
更新日期：2007-07-01 00:00:00
abstract：:1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9228-5
更新日期：2011-08-01 00:00:00
