Development and evolution of RORγt+ cells in a microbe's world.

abstract：:Clarifying the signals that lead to dendritic cell (DC) development and identifying cellular intermediates on their way to DC differentiation are essential steps to understand the dynamic regulation of number, localization, and functionality of these cells. In the past decade, much knowledge on cytokines, transcriptio...

journal_title：Immunological reviews

authors： Schmid MA,Kingston D,Boddupalli S,Manz MG

更新日期：2010-03-01 00:00:00

abstract：:Considerable progress has been made in defining intermediate stages in the process leading from stem cells to mature B cells. Cell-bound and secreted molecules direct the progression through these stages and regulate the selection of clones from which the immune repertoire emerges. In fact, a myriad of signals derived...

journal_title：Immunological reviews

authors： Stoddart A,Fleming HE,Paige CJ

更新日期：2000-06-01 00:00:00

abstract：:Nuclear-factor κB (NF-κB) transcription factors are activated by a wide variety of stimuli in diverse cell types and control key aspects of immune function and development. Receptor-mediated activation of NF-κB appears to occur through two distinct signaling pathways termed as the canonical and non-canonical NF-κB pat...

journal_title：Immunological reviews

authors： Razani B,Reichardt AD,Cheng G

更新日期：2011-11-01 00:00:00

abstract：:Cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery through a series of mechanisms that include the induction of anergy, dominant suppression by regulatory T cells, and peripheral deletion of self-reactive T cells. Calcium signaling plays a central role in the inductio...

journal_title：Immunological reviews

authors： Baine I,Abe BT,Macian F

更新日期：2009-09-01 00:00:00

abstract：:BCL6 is a transcriptional repressor required in mature B cells during the germinal center (GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at transcriptional and post-transcriptional levels. BCL6 prevents premature activation and differentiation of GC B cells and provides an envir...

journal_title：Immunological reviews

authors： Basso K,Dalla-Favera R

更新日期：2012-05-01 00:00:00

abstract：:Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the ...

journal_title：Immunological reviews

authors： Lyakh L,Trinchieri G,Provezza L,Carra G,Gerosa F

更新日期：2008-12-01 00:00:00

abstract：:Regulatory T cells (Tregs) are critical to the human immune system, providing appropriately scaled immune responses and mediating peripheral tolerance. A central role for forkhead box protein 3 (FoxP3)(+) Tregs has been shown in the pathogenesis of mechanistically diverse central nervous system (CNS) diseases from aut...

journal_title：Immunological reviews

authors： Lowther DE,Hafler DA

更新日期：2012-07-01 00:00:00

abstract：:The epithelium of the human small intestine contains a large population of intraepithelial cytolytic alphabeta T-cell receptor (TCR) CD8 alpha beta T lymphocytes (IE-CTLs), whose main role is to sustain epithelial integrity by rapidly eliminating infected and damaged cells. In mouse, the recognition of inducible/modif...

journal_title：Immunological reviews

authors： Jabri B,Ebert E

更新日期：2007-02-01 00:00:00

abstract：:Resistance to infection with Listeria monocytogenes involves a series of cellular interactions, many of which are carried out by cytokines. Macrophages, NK cells and neutrophils participate in early stages of Listeria resistance. The neutrophil is specially important for clearance of the liver phase of listeriosis. Ma...

journal_title：Immunological reviews

authors： Unanue ER

更新日期：1997-08-01 00:00:00

abstract：:The actin cytoskeleton network forms a key link between T-cell antigen receptor (TCR) stimulation and T-cell effector functions, providing a structural basis for T-cell morphological changes and signal transduction. Accumulating evidence positions the Wiskott-Aldrich syndrome protein (WASp), a scaffolding protein that...

journal_title：Immunological reviews

authors： Matalon O,Reicher B,Barda-Saad M

更新日期：2013-11-01 00:00:00

abstract：:Ozone (O(3)) and endotoxin are common environmental contaminants that cause asthma exacerbation. These pollutants have similar phenotype response characteristics, including induction of neutrophilic inflammation, changes in airway macrophage immunophenotypes, and ability to enhance response to inhaled allergen. Evoked...

journal_title：Immunological reviews

authors： Peden DB

更新日期：2011-07-01 00:00:00

abstract：SUMMARY:This volume covers many topics in the field of T-cell costimulation. The need for such a volume is testament to the growth of the field. From its beginning as a concept in the 1980s, we have now progressed to the point where many molecules now have functionally defined roles in T-cell costimulation. In addition...

journal_title：Immunological reviews

authors： Linsley PS,Nadler SG

更新日期：2009-05-01 00:00:00

abstract：:The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains and receptors and is a critical mediator of intracellular signals. ITAM-mediated signals depend on the Syk or zeta-associated protein of 70 kDa tyrosine kinases, and ITAM signaling is re...

journal_title：Immunological reviews

authors： Humphrey MB,Lanier LL,Nakamura MC

更新日期：2005-12-01 00:00:00

abstract：:Viral infections may induce and sustain autoimmune processes via several and overlapping mechanisms. We outline how chronic inflammation, sustained by persisting viruses, may be "the prerequisite" for initiation and maintenance of the multistep process leading to autoimmunity. Chronic inflammation may favour priming o...

journal_title：Immunological reviews

authors： Di Rosa F,Barnaba V

更新日期：1998-08-01 00:00:00

abstract：:In addition to its effects on sexual differentiation and reproduction, estrogen has important impact on the immune system and on bone. It has also been evident that the effects of estrogen on bone to a large extent are mediated via its action on immune cells. Estrogen has a dichotomous impact on the immune system by d...

journal_title：Immunological reviews

authors： Carlsten H

更新日期：2005-12-01 00:00:00

abstract：:NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the kille...

journal_title：Immunological reviews

authors： Lanier LL,Corliss B,Phillips JH

更新日期：1997-02-01 00:00:00

abstract：:Mycobacterium tuberculosis has evolved from a Mycobacterium canettii-like progenitor pool into one of the most successful and widespread human pathogens. The pathogenicity of M. tuberculosis is linked to its ability to secrete/export/release selected mycobacterial proteins, and it is also established that active relea...

journal_title：Immunological reviews

authors： Majlessi L,Prados-Rosales R,Casadevall A,Brosch R

更新日期：2015-03-01 00:00:00

abstract：:Mouse retrovirus-induced lymphoma/leukemia and immunodeficiency are useful models for analogous human diseases. Both ecotropic (mouse tropic) and recombinant retroviruses, including the polytropic mink cytopathic focus-inducing type, have been studied for disease pathogenesis and as targets for humoral and cellular im...

journal_title：Immunological reviews

authors： Green WR

更新日期：1999-04-01 00:00:00

abstract：:The bronchus-associated lymphoid tissue (BALT) and the nasal-associated lymphoid tissue (NALT) constitute organized lymphoid aggregates that are capable of T- and B-cell responses to inhaled antigens. BALT, located mostly at bifurcations of the bronchus in animals and humans, is present in the fetus and develops rapid...

journal_title：Immunological reviews

authors： Bienenstock J,McDermott MR

更新日期：2005-08-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important cause of respiratory disease causing high rates of hospitalizations in infants, significant morbidity in children and adults, and excess mortality in the elderly. Major barriers to vaccine development include early age of RSV infection, capacity of RSV to evade innate ...

journal_title：Immunological reviews

authors： Graham BS

更新日期：2011-01-01 00:00:00

abstract：:Activation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. Within the mitogen-activated protein kinases (MAPKs) family, the stress-activated protein kinase (SAPK) group was defined as group of kinases that activated by stimuli that ...

journal_title：Immunological reviews

authors： Rincón M,Davis RJ

更新日期：2009-03-01 00:00:00

abstract：:T cells (derived from peripheral blood lymphocytes [PBL], lymph nodes or tumor tissues and restimulated with autologous tumor cells and expanded in interleukin-2 [IL-2]), when cloned, produce three functional classes of clone. Class I T-cell clones exhibit the phenotype of alpha/beta cytotoxic T lymphocytes (CD3+, CD8...

journal_title：Immunological reviews

authors： Mukherji B,Chakraborty NG,Sivanandham M

更新日期：1990-08-01 00:00:00

abstract：:Hematopoietic stem cell transplantation has been used for more than 50 years to combat hematologic malignancies. In addition to being the first stem cell therapy, transplantation has provided evidence for the potent anti-tumor effects of T cells. Facilitating T-cell-based immunity against malignancies requires a caref...

journal_title：Immunological reviews

authors： Ghosh A,Holland AM,van den Brink MR

更新日期：2014-01-01 00:00:00

abstract：:Chemokines control selective targeting of circulating leukocytes to the microvasculature by triggering inside-out signal transduction pathways leading to integrin-dependent adhesion. Integrin activation by chemokines is very rapid, is downmodulated within minutes and appears to involve both enhanced heterodimer latera...

journal_title：Immunological reviews

authors： Laudanna C,Kim JY,Constantin G,Butcher E

更新日期：2002-08-01 00:00:00

abstract：:This review discusses situations when the magnitude and function of immune responses to virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ forkhead box protein 3+ natural Tregs (nTregs). The immune response may be limited in magnitude and efficacy when animals with normal nTreg fu...

journal_title：Immunological reviews

authors： Rouse BT,Sarangi PP,Suvas S

更新日期：2006-08-01 00:00:00

abstract：:Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo- and heterotypic intrafamilial interactions to exert diverse functio...

journal_title：Immunological reviews

authors： Read KA,Jones DM,Freud AG,Oestreich KJ

更新日期：2020-12-17 00:00:00

abstract：:The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular int...

journal_title：Immunological reviews

authors： Ugur M,Mueller SN

更新日期：2019-05-01 00:00:00

abstract：:Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...

journal_title：Immunological reviews

authors： Annacker O,Pimenta-Araujo R,Burlen-Defranoux O,Bandeira A

更新日期：2001-08-01 00:00:00

abstract：:Basal, activation, and arrest signaling in T cells determines survival, coordinates responses to pathogens, and, when dysregulated, leads to loss of self-tolerance and autoimmunity. At the T-cell surface, transmembrane glycoproteins interact with galectins via their N-glycans, forming a molecular lattice that regulate...

journal_title：Immunological reviews

authors： Grigorian A,Torossian S,Demetriou M

更新日期：2009-07-01 00:00:00

abstract：:BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and funct...

journal_title：Immunological reviews

authors： Ramanathan S,Poussier P

更新日期：2001-12-01 00:00:00