Abstract:
BACKGROUND:Topical retinoids induce skin fragility. As corneodesmosomes are important adhesion structures in the epidermal cohesion, an effect of retinoids on corneodesmosomes has been suspected. OBJECTIVE:The aim of this study was to investigate the effect of retinoid on the expression of corneodesmosomal components including desmoglein (DSG) 1, desmocollin (DSC) 1, corneodesmosin (CDSN) and kallikrein (KLK)s. METHODS:2% all-trans-retinol or ethanol was applied to the back of hairless mice for five days, and the structure of the stratum corneum was examined by transmission electron microscopy. The cultured human keratinocytes were treated with all-trans-retinoic acid (RA) in low or high calcium media for 24 hours. RESULTS:Topical retinol increased corneocyte detachment and degradation of corneodesmosomes. RA significantly decreased DSG1 and DSC1 expression at the mRNA and protein levels in keratinocytes that were cultured in both low- and high-calcium media. On the other hand, CDSN mRNA levels did not decrease in low-calcium media or increase in high-calcium media after RA treatment. KLK5 and KLK7 expression did not increase after RA treatment. CONCLUSION:Our results indicate that DSG1 and DSC1 downregulation by RA could be related to the increased degradation of corneodesmosomes and consequent desquamation induced by retinoids.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Kim MY,Lee SE,Chang JY,Kim SCdoi
10.5021/ad.2011.23.4.439subject
Has Abstractpub_date
2011-11-01 00:00:00pages
439-47issue
4eissn
1013-9087issn
2005-3894journal_volume
23pub_type
杂志文章abstract:BACKGROUND:The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE:We evaluated the anti...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.5.584
更新日期:2014-10-01 00:00:00
abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S131
更新日期:2011-09-01 00:00:00
abstract::Matridex(R) is an injectable skin filler that's composed of a mixture of cross linked hyaluronic acid and dextranomer particles, and it was recently developed for soft tissue augmentation. To the best of our knowledge, there have been few previous reports on complications associated with Matridex. We report here on a ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.1.81
更新日期:2010-02-01 00:00:00
abstract::Intravascular lymphoma (IVL) is a rare disorder characterized by the presence of large neoplastic lymphoid cells restricted to the lumens of small vessels with a predilection for the skin and the central nervous system. While the vast majority of cases involving IVL are of B-cell lineage, the disease rarely affects th...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.4.496
更新日期:2014-08-01 00:00:00
abstract::A 28-year-old woman presented with multiple, asymptomatic, erythematous to bluish papules located on the chest. Histopathologically, three round, well defined cystic structures were seen on the upper and lower dermis. The first cyst was milia, the second was apocrine hidrocystoma and the other, largest cyst was an eru...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.1.11
更新日期:2008-03-01 00:00:00
abstract::Blastomycosis-like pyoderma is a rare, vegetating skin lesion that is an unusual exaggerated tissue reaction possibly to prolonged primary or secondary bacterial infection. We report a case of blastomycosis-like pyoderma in a man with Down syndrome, diabetes mellitus and hypothyroidism who responsed poorly to conventi...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.3.365
更新日期:2011-08-01 00:00:00
abstract::Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). Recently, hemidesmosomal EB has been propo...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S41
更新日期:2011-09-01 00:00:00
abstract::Focal acral hyperkeratosis (FAH) is a rare genodermatosis with an autosomal dominant pattern of inheritance; however, it may also be sporadic. FAH is characterized by late-onset crateriform keratotic papules, some coalescing into plaques, along the borders of the hands and feet. We herein report a case of FAH in a 47-...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.4.426
更新日期:2009-11-01 00:00:00
abstract::Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases bec...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2015.27.4.431
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PAS...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.5.557
更新日期:2015-10-01 00:00:00
abstract::Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, m...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2018.30.2.214
更新日期:2018-04-01 00:00:00
abstract::Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.1.119
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Several workers have found that Malassezia are capable of suppressing cytokine release and downregulating the phagocytic function of monocytes. But lipid-depleted Malassezia furfur (M. furfur) extracts have also been shown to induce increased production of TNF-alpha, IL-6 and IL-1beta in monocytes. We though...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.2.130
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE:This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS:A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All pati...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.4.371
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.2.143
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We exam...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2008.20.2.49
更新日期:2008-06-01 00:00:00
abstract::Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are characterized by the T-cell immunophenotype. Here, we report the first Korean case of EBV-ass...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.5.618
更新日期:2017-10-01 00:00:00
abstract::Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2015.27.3.315
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is involved in the developmental and disease processes of various cells and tissues by modulating the Wnt pathway. OBJEC...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.1.79
更新日期:2014-02-01 00:00:00
abstract::This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discont...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S404
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.6.709
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The clinical symptoms of facial and truncal acne differ. Skin surface acidity (pH), which is affected by sebum secretions, reflects the different clinical characteristics of the face and trunk. However, no studies have been conducted on truncal sebum production and skin pH. OBJECTIVE:We evaluated the differ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.2.216
更新日期:2016-04-01 00:00:00
abstract::Nuchal-type fibroma is a rare, benign, fibrous, tumor-like proliferation characterized by dense hypocellular bundles of collagen, with sparsely scattered fibroblasts, interspersed fat tissue, and entrapped nerve fibers. It usually develops in the posterior neck as a solitary, firm, poorly circumscribed, subcutaneous m...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2015.27.2.194
更新日期:2015-04-01 00:00:00
abstract::Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2012.24.3.345
更新日期:2012-08-01 00:00:00
abstract::Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few case...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.358
更新日期:2010-08-01 00:00:00
abstract::Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.2.201
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Progressive macular hypomelanosis is characterized by ill-defined, non-scaly, hypopigmented macules primarily on the trunk of the body. Although numerous cases of progressive macular hypomelanosis have been reported, there have been no clinicopathologic studies of progressive macular hypomelanosis in Korean ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.3.261
更新日期:2009-08-01 00:00:00
abstract::Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.4.539
更新日期:2011-11-01 00:00:00
abstract::Nicolau syndrome is a rare adverse reaction to a variety of intra-muscular drug preparations. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, hemorrhagic patch, and finally, necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.4.501
更新日期:2011-11-01 00:00:00
abstract::We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.1.98
更新日期:2009-02-01 00:00:00