Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study.

Abstract:

BACKGROUND:Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE:This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS:A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician's global assessment (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points. RESULTS:After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p< 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients. CONCLUSION:This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Park JM,Cho HH,Kim WJ,Mun JH,Song M,Kim HS,Ko HC,Kim BS,Kim MB

doi

10.5021/ad.2015.27.4.371

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

371-5

issue

4

eissn

1013-9087

issn

2005-3894

journal_volume

27

pub_type

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