Expression of sfrp2 is increased in catagen of hair follicles and inhibits keratinocyte proliferation.


BACKGROUND:Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is involved in the developmental and disease processes of various cells and tissues by modulating the Wnt pathway. OBJECTIVE:The aim of this study was to understand the role of Sfrp2 in hair follicles through investigation of the Sfrp2 expression pattern in the skin and its effect on keratinocytes. METHODS:We investigated Sfrp2 mRNA expression and the expression of the wnt target genes, Ccnd1 and C-myc, at various mouse hair follicle developmental stages using Real-time polymerase chain reaction. We also investigated the effect of SFRP2 on the proliferation and differentiation of mouse keratinocyte cells by adding SFRP2 protein or overexpressing Sfrp2 using an in vitro culture system. RESULTS:Sfrp2 expression peaked in the catagen phase and remained high until telogen, and then declined at the beginning of the next anagen. An inverse relationship to Sfrp2 expression was found for the expression of the Wnt target genes, C-myc and Ccnd1. In addition, we also observed inhibited proliferation of mouse keratinocytes in the presence of SFRP2. CONCLUSION:These results suggest that Sfrp2 may play a role in the catagen phase by inhibiting the proliferation of keratinocyte and functioning as a Wnt inhibitor in keratinocytes.


Ann Dermatol


Annals of dermatology


Kim BK,Yoon SK




Has Abstract


2014-02-01 00:00:00












  • A case of childhood lichen aureus.

    abstract::Lichen aureus is a rare type of chronic pigmented purpuric dermatosis. The eruptions consist of discrete or confluent golden to brownish lichenoid macules and papules, and are usually asymptomatic. Lichen aureus commonly occurs in young adults, but less frequently in children. We report the first case of multiple lich...

    journal_title:Annals of dermatology



    authors: Kim MJ,Kim BY,Park KC,Youn SW

    更新日期:2009-11-01 00:00:00

  • A granulomatous drug eruption induced by entecavir.

    abstract::Entecavir (Baraclude®, Bristol-Myers Squibb) is a potent and selective antiviral agent that has demonstrated efficacy in patients with chronic hepatitis B. The most frequent adverse events attributed to entecavir include increased alanine aminotransferase, upper respiratory tract infection, headache, abdominal pain, c...

    journal_title:Annals of dermatology



    authors: Yoon J,Park D,Kim C

    更新日期:2013-11-01 00:00:00

  • Insect Bite-Like Reaction with Bullous Lesions Mimicking Bullous Pemphigoid in a Patient with Chronic Lymphocytic Leukemia.

    abstract::Patients with chronic lymphocytic leukemia (CLL) rarely exhibit an exaggerated insect bite-like reaction without a history of an arthropod bite. We report a case of an insect bite-like reaction in a 74-year old man with CLL. The patient presented with a 2-year history of recurrent itchy erythematous patches and bliste...

    journal_title:Annals of dermatology



    authors: Kim JE,Kim SC

    更新日期:2018-08-01 00:00:00

  • Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft.

    abstract:BACKGROUND:There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE:The purpose of our research was to isolate and meas...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Maniatopoulou E,Bonovas S,Sitaras N

    更新日期:2016-10-01 00:00:00

  • Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Cho HJ,Cho SI,Kim HO,Park CW,Lee CH

    更新日期:2013-05-01 00:00:00

  • Basal cell carcinoma-mimicking lesions in korean clinical settings.

    abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer and possesses various clinical features including translucency, ulceration, pigmentation, telangiectasia, and rolled borders. Accordingly, many cutaneous lesions can mimic BCCs and differential diagnosis is difficult. OBJECTIVE:To clarify the...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Kim HS,Kim TW,Mun JH,Song M,Ko HC,Kim BS,Kim MB

    更新日期:2014-08-01 00:00:00

  • Acute localized exanthematous pustulosis on the face.

    abstract::Acute localized exanthematous pustulosis (ALEP) is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 26-year-old woman presented with multiple erythematous pustules on her face, which had appeared th...

    journal_title:Annals of dermatology



    authors: Sim HS,Seol JE,Chun JS,Seo JK,Lee D,Sung HS

    更新日期:2011-12-01 00:00:00

  • A Case of Varicella Combined with Hand-foot-mouth Disease in a Healthy Child.

    abstract::We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...

    journal_title:Annals of dermatology



    authors: Na SY,Son YM,Lee HY,Baek JO,Roh JY,Lee JR

    更新日期:2009-02-01 00:00:00

  • A case of giant folliculosebaceous cystic hamartoma.

    abstract::Clinically, folliculosebaceous cystic hamartoma (FSCH) lacks distinct features, but it has been reported as an asymptomatic, 1- to 3-cm, dome-shaped nodule on the face. Histopathologically, FSCH is characterized by adnexal and folliculosebaceous cystic proliferation with various mesenchymal changes. This case presente...

    journal_title:Annals of dermatology



    authors: Haw S,Lee MH

    更新日期:2009-02-01 00:00:00

  • Localized Telogen Effluvium Following Hair Transplantation.

    abstract::Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, m...

    journal_title:Annals of dermatology



    authors: Loh SH,Lew BL,Sim WY

    更新日期:2018-04-01 00:00:00

  • Identification of dermatophytes using multiplex polymerase chain reaction.

    abstract:BACKGROUND:Multiplex polymerase chain reaction (PCR) allows more than two target DNA molecules to be amplified with more than two primers. This method is also useful for detecting various other organisms simultaneously within a single test tube, and the scope of its use has been expanding widely in the field of clinica...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Kim JY,Choe YB,Ahn KJ,Lee YW

    更新日期:2011-08-01 00:00:00

  • Impact of postthyroidectomy scar on the quality of life of thyroid cancer patients.

    abstract:BACKGROUND:Surgical scars are crucial cosmetic problem, especially when in exposed areas such as the anterior neck following thyroidectomy. OBJECTIVE:To evaluate the impact of post-thyroidectomy scars on quality of life (QoL) of thyroid cancer patients and identify the relationship between scar characteristics and QoL...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Choi Y,Lee JH,Kim YH,Lee YS,Chang HS,Park CS,Roh MR

    更新日期:2014-12-01 00:00:00

  • Beneficial Effect of Low Fluence 1,064 nm Q-Switched Neodymium:Yttrium-Aluminum-Garnet Laser in the Treatment of Senile Lentigo.

    abstract:BACKGROUND:Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo. OBJECTIVE:To investigate the b...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Nam JH,Kim HS,Lee GY,Kim WS

    更新日期:2017-08-01 00:00:00

  • Effect of probiotics on the treatment of children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Yeşilova Y,Çalka Ö,Akdeniz N,Berktaş M

    更新日期:2012-05-01 00:00:00

  • Congenital and multiple hobnail hemangiomas.

    abstract::Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typ...

    journal_title:Annals of dermatology



    authors: Yoon SY,Kwon HH,Jeon HC,Lee JH,Cho S

    更新日期:2011-11-01 00:00:00

  • A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum.

    abstract::Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who p...

    journal_title:Annals of dermatology



    authors: Seo JW,Son HH,Choi JH,Lee SK

    更新日期:2010-02-01 00:00:00

  • Differences in the known cellular composition of benign pigmented skin lesions reflected in computer-aided image analysis.

    abstract:BACKGROUND:Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE:The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the diffe...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Choi JW,Ryu HH,Byun SY,Youn SW

    更新日期:2014-06-01 00:00:00

  • Erratum: ERRATUM.

    abstract::[This corrects the article on p. 217 in vol. 21.]. ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章



    更新日期:2009-08-01 00:00:00

  • A case of membranous lipodystrophy observed in lichen amyloidosis.

    abstract::Membranous lipodystrophy is characterized by the presence of microcysts lined by amorphous, eosinophilic material with an arabesque appearance. We experienced a case of a 72-year-old man who had dark brownish, pruritic papules on the arms, legs, and back. Histopathologic examination of a biopsied lesion showed homogen...

    journal_title:Annals of dermatology



    authors: Lee Y,Ahn SY,Ji JH,Hong SP,Bak H,Lee SH,Ahn SK

    更新日期:2009-05-01 00:00:00

  • A Case of Idiopathic Eruptive Macular Pigmentation Limited to Flexural Areas.

    abstract::Idiopathic eruptive macular pigmentation is a rare condition characterized by asymptomatic pigmented macules involving the neck, trunk, and proximal portions of the extremities. On histopathologic examination, there was increased pigmentation of the basal layer in otherwise normal epidermis and scattered melanophages ...

    journal_title:Annals of dermatology



    authors: Kim EH,Lee ES,Kim YC,Kang HY

    更新日期:2008-06-01 00:00:00

  • Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine.

    abstract:BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Kim JM,Lim KM,Kim HS,Ko HC,Kim MB,Kim BS

    更新日期:2017-04-01 00:00:00

  • Chemokine Receptor CCR3 Expression in Malignant Cutaneous Tumors.

    abstract:BACKGROUND:Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. OBJECTIVE:The aim of this study was to de...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Lee YJ,Kim DH,Lee SH,Nam HS,Roh MR,Cho MK

    更新日期:2010-11-01 00:00:00

  • Two cases of unilateral lichen planus following the lines of blaschko.

    abstract::A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planu...

    journal_title:Annals of dermatology



    authors: Yayla D,Külcü Çakmak S,Oğuz ID,Gönül M,Ozhamam E,Colak A,Gül U

    更新日期:2014-10-01 00:00:00

  • The short stature in atopic dermatitis patients: are atopic children really small for their age?

    abstract:BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Park MK,Park KY,Li K,Seo SJ,Hong CK

    更新日期:2013-02-01 00:00:00

  • The clinical efficacy, safety and functionality of anion textile in the treatment of atopic dermatitis.

    abstract:BACKGROUND:Several previous studies have suggested the improvement of atopic dermatitis (AD) in response to special fabrics. In particular, beneficial effects have been reported, following the use of anion textiles. OBJECTIVE:The purpose of this study is to evaluate the effectiveness and safety of an anion textile in ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Kim SH,Hwang SH,Hong SK,Seo JK,Sung HS,Park SW,Shin JH

    更新日期:2012-11-01 00:00:00

  • Reduction of Inter-Rater and Intra-Rater Variability in Psoriasis Area and Severity Index Assessment by Photographic Training.

    abstract:BACKGROUND:Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PAS...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Youn SW,Choi CW,Kim BR,Chae JB

    更新日期:2015-10-01 00:00:00

  • Disease awareness and management behavior of patients with atopic dermatitis: a questionnaire survey of 313 patients.

    abstract:BACKGROUND:Patients with atopic dermatitis (AD) should be relatively well informed about the disorder to control their condition and prevent flare-ups. Thus far, there is no accurate information about the disease awareness levels and therapeutic behavior of AD patients. OBJECTIVE:To collect data on patients' knowledge...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Kim JE,Lee YB,Lee JH,Kim HS,Lee KH,Park YM,Cho SH,Lee JY

    更新日期:2015-02-01 00:00:00

  • Change in Antimicrobial Susceptibility of Skin-Colonizing Staphylococcus aureus in Korean Patients with Atopic Dermatitis during Ten-Year Period.

    abstract:BACKGROUND:A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE:It w...

    journal_title:Annals of dermatology

    pub_type: 杂志文章


    authors: Park JM,Jo JH,Jin H,Ko HC,Kim MB,Kim JM,Kim DW,Jang HS,Kim BS

    更新日期:2016-08-01 00:00:00

  • A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus.

    abstract::Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp. ...

    journal_title:Annals of dermatology



    authors: Kim MS,Lee JH,Lee WM,Son SJ

    更新日期:2010-08-01 00:00:00

  • Case of epidermolysis bullosa with pyloric atresia.

    abstract::Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). Recently, hemidesmosomal EB has been propo...

    journal_title:Annals of dermatology



    authors: Kim JH,Park HY,Lee HJ,Eom M,Choi EH

    更新日期:2011-09-01 00:00:00