Psoriasis, Vitiligo and Crohn's Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?

Abstract:

:Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn's disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn's disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Lee SH,Kim YS,Kim HJ,Park YL

doi

10.5021/ad.2017.29.6.782

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

782-785

issue

6

eissn

1013-9087

issn

2005-3894

journal_volume

29

pub_type

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