Abstract:
BACKGROUND:Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE:This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma), Aminexil, Dercos (Vichy Laboratoires), and Kerium, Anti-chute (La Roche-Posay). METHODS:Thirty-two adult female Wistar-Bratislava rats were assigned to 4 groups. Two rectangular areas (2×4 cm) were shaved on either sides of the mid dorsal line (left side - control; right side - test area). Group I was treated topically with 2% minoxidil, group II with Aminexil, and group III with Kerium. Each rat received 0.3 ml of substance applied topically to the shaved dorsal skin every day for 28 days. Rats in group IV served as sham controls receiving no treatment. Hair regrowth was evaluated by trichoscopy (with a dermatoscope), grown hair weight (from a surface area of 1 cm(2)), and histopathological examination for skin thickness, follicle count, and percentage of anagen induction (morphometric assessment). RESULTS:Treatment with 2% minoxidil significantly induced hair regrowth as assessed by trichoscopy, hair weight examination, and morphometric evaluation. Hair weight examination and morphometric assessment demonstrated the lowest hair growth effect with Aminexil among the tested products. Treatment with Kerium was found to significantly induce hair regrowth (p<0.05 as compared to the control group). CONCLUSION:Our study demonstrates that hair regrowth efficacy of products recommended for human use is not similar when tested on an animal model.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Orasan MS,Bolfa P,Coneac A,Muresan A,Mihu Cdoi
10.5021/ad.2016.28.1.65subject
Has Abstractpub_date
2016-02-01 00:00:00pages
65-73issue
1eissn
1013-9087issn
2005-3894journal_volume
28pub_type
杂志文章abstract:BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.1.23
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE:This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS:A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All pati...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.4.371
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Stress is a known cause of hair loss in many species. OBJECTIVE:In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS:Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of r...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.5.600
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Surgical scars are crucial cosmetic problem, especially when in exposed areas such as the anterior neck following thyroidectomy. OBJECTIVE:To evaluate the impact of post-thyroidectomy scars on quality of life (QoL) of thyroid cancer patients and identify the relationship between scar characteristics and QoL...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.6.693
更新日期:2014-12-01 00:00:00
abstract:Background:No study to date has focused on the changes in laboratory test results and related risk factors in patients with psoriasis treated with prolonged Cyclosporine A (CsA) therapy. Objective:The objective of this study was to investigate the changes of laboratory values and related risk factors in patients with ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2018.30.2.143
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is involved in the developmental and disease processes of various cells and tissues by modulating the Wnt pathway. OBJEC...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.1.79
更新日期:2014-02-01 00:00:00
abstract::Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2015.27.3.315
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The extracellular matrix (ECM) produced by dermal fibroblasts supports skin structure, and degradation and/or reduced production of ECM are the main causes of wrinkle formation. OBJECTIVE:The aim of this study was to identify the active ingredient that enhances ECM production in dermal fibroblasts. METHODS...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.1.16
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE:It w...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.4.470
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is an autoimmune skin disease difficult to manage and treat. The pathogenesis of AA features a T-cell-associated autoimmune process, and systemic immunosuppressive therapy is prescribed widely for AA. OBJECTIVE:To evaluate the efficacy and tolerance of systemic low-dose methotrexate (LD...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.3.263
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.1.18
更新日期:2009-02-01 00:00:00
abstract::A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planu...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.5.636
更新日期:2014-10-01 00:00:00
abstract::We report on a rare case of fluconazole induced fixed drug eruption in a 62-year old female patient. She was referred to our department for multiple erythematous itchy maculopatches on the face, neck, both upper arms, and trunk area, which had occurred over the previous 6 months. Her attending physician prescribed flu...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S1
更新日期:2011-09-01 00:00:00
abstract::Pityriasis alba (PA) is a common benign disease, characterized by hypopigmented macules or patches on the face, usually seen in children. However, two uncommon variants exist, a pigmenting type and an extensive type. Extensive PA is rare. The lesions tend to be less scaly, more persistent, more generalized, more symme...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.3.146
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. OBJECTIVE:Novel vehicles for topical glucocorticoids formulation were ev...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.1.5
更新日期:2013-02-01 00:00:00
abstract::Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid de...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.2.186
更新日期:2010-05-01 00:00:00
abstract::Membranous lipodystrophy is characterized by the presence of microcysts lined by amorphous, eosinophilic material with an arabesque appearance. We experienced a case of a 72-year-old man who had dark brownish, pruritic papules on the arms, legs, and back. Histopathologic examination of a biopsied lesion showed homogen...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.2.174
更新日期:2009-05-01 00:00:00
abstract::Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from ec...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S79
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE:To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS:...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.6.711
更新日期:2016-12-01 00:00:00
abstract::[This corrects the article on p. 217 in vol. 21.]. ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.3.335
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Multiplex polymerase chain reaction (PCR) allows more than two target DNA molecules to be amplified with more than two primers. This method is also useful for detecting various other organisms simultaneously within a single test tube, and the scope of its use has been expanding widely in the field of clinica...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2011.23.3.304
更新日期:2011-08-01 00:00:00
abstract::Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenita...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.3.381
更新日期:2014-06-01 00:00:00
abstract:Background:Prevalence of subungual melanoma (SUM) in Asian population is relatively high and early clinical detection improves both quality of life and survival. Objective:We sought to establish screening strategy for SUM in situ. Methods:We retrospectively reviewed medical records of 8 patients pathologically diagno...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2018.30.1.36
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We exam...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2008.20.2.49
更新日期:2008-06-01 00:00:00
abstract::Clinically, folliculosebaceous cystic hamartoma (FSCH) lacks distinct features, but it has been reported as an asymptomatic, 1- to 3-cm, dome-shaped nodule on the face. Histopathologically, FSCH is characterized by adnexal and folliculosebaceous cystic proliferation with various mesenchymal changes. This case presente...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.1.63
更新日期:2009-02-01 00:00:00
abstract::Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S329
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.6.709
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for w...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.1.1
更新日期:2014-02-01 00:00:00
abstract::Bowen's disease usually manifests as a slowly enlarging erythematous scaly patch or plaque. An uncommon variant of Bowen's disease showing a verrucous appearance has been reported and a distinct variant with a prominent clear cell change on histopathology, in addition to a verrucous surface change, was also reported. ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.4.487
更新日期:2017-08-01 00:00:00
abstract::Although more than 90% of melanomas have cutaneous origins, melanomas sometimes present metastatically with no apparent primary lesion. A 62-year-old female presented with black pigmentation on her left thumbnail that had begun 2 years earlier and after the biopsy, she was diagnosed with malignant melanoma. Interestin...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S274
更新日期:2011-10-01 00:00:00