Abstract：
:Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with neighboring keratinocytes. In fact, direct cell-to cell contact stimulates in vitro proliferation of melanocytes, and growth factors produced by adjacent keratinocytes regulate the proliferation and differentiation of melanocytes. The potential role of keratinocyte-derived cytokines has also been presented. We focused on the structural changes in vitiliginous keratinocytes, which may result in loss of melanocytes, to examine the pathomechanism of vitiligo. The results of a comparison between depigmented and normally pigmented epidermis in patients with vitiligo showed that the keratinocytes in the depigmented epidermis were more vulnerable to apoptosis. Impaired Phosphatidylinositol 3-kinase (PI3K)/serine/threonine protein kinase (Akt) activation followed by reduced nuclear factor-κB activation under increased tumor necrosis factor-α levels was demonstrated as a mechanism for keratinocyte apoptosis. The role of aquaporin 3 in keratinocyte apoptosis was addressed based on the relationship between the PI3K/AKT pathway and the E-cadherin-catenin complex. Apoptotic keratinocytes induced a lower expression of keratinocyte-derived factors, including stem cell factor, in depigmented epidermis, resulting in passive melanocyte death.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Lee AYdoi
10.5021/ad.2012.24.2.115subject
Has Abstractpub_date
2012-05-01 00:00:00pages
115-25issue
2eissn
1013-9087issn
2005-3894journal_volume
24pub_type
杂志文章abstract：BACKGROUND:Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo. OBJECTIVE:To investigate the b...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.4.427
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2012.24.2.189
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2009.21.1.18
更新日期：2009-02-01 00:00:00
abstract：:Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.2.201
更新日期：2011-05-01 00:00:00
abstract：:A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planu...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.5.636
更新日期：2014-10-01 00:00:00
abstract：:Blastomycosis-like pyoderma is a rare, vegetating skin lesion that is an unusual exaggerated tissue reaction possibly to prolonged primary or secondary bacterial infection. We report a case of blastomycosis-like pyoderma in a man with Down syndrome, diabetes mellitus and hypothyroidism who responsed poorly to conventi...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.3.365
更新日期：2011-08-01 00:00:00
abstract：:Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fa...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.1.81
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2011.23.1.33
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE:The purpose of our research was to isolate and meas...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2016.28.5.533
更新日期：2016-10-01 00:00:00
abstract：:Melanocytic nevi are subject to change with age in both clinical and histopathologic findings. In 1991, Cho et al. first reported three cases of lobulated intradermal nevi and suggested their cases represented an unusual form of regressing melanocytic nevus. Herein we report four cases of lobulated intradermal nevus a...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.1.115
更新日期：2011-02-01 00:00:00
abstract：:Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few case...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2010.22.3.358
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:There exists a treatment challenge with periungual warts. Topical immunotherapy with diphenylcyclopropenone (DPCP) has recently been reported to be an effective treatment for recalcitrant warts, including periungual types. OBJECTIVE:We aimed to evaluate the effectiveness and preference of topical immunother...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.4.434
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PAS...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.5.557
更新日期：2015-10-01 00:00:00
abstract：:An atypical clinical form of pityriasis versicolor has been infrequently reported, in which cutaneous atrophy is associated with individual pityriasis versicolor lesions. The pathogenesis of this atrophy remains unclear, but is believed to be a delayed-type hypersensitivity reaction to antigens derived from the Malass...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2010.22.4.456
更新日期：2010-11-01 00:00:00
abstract：:Leiomyosarcomas are uncommon malignant smooth muscle tumors, mainly derived from vessels or viscera. Superficial leiomyosarcomas are a rare soft tissue sarcoma arising from the dermis or subcutaneous tissue in the skin. According to tumor origin and location, they are divided into cutaneous and subcutaneous leiomyosar...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2013.25.2.237
更新日期：2013-05-01 00:00:00
abstract：:Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases bec...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2015.27.4.431
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.2.189
更新日期：2013-05-01 00:00:00
abstract：Background:Alopecia areata (AA) affects anagen hair follicles resulting in non-scarring hair loss. Since its introduction, superficial cryotherapy has been used as one of the meaningful treatment modalities for AA. Objective:The purpose of this study is to clarify the therapeutic efficacy and safety of superficial cry...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.6.722
更新日期：2017-12-01 00:00:00
abstract：:We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.1.98
更新日期：2009-02-01 00:00:00
abstract：:Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.6.751
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.1.23
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE:The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the diffe...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2014.26.3.314
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.6.709
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Alopecia areata (AA) is an autoimmune skin disease difficult to manage and treat. The pathogenesis of AA features a T-cell-associated autoimmune process, and systemic immunosuppressive therapy is prescribed widely for AA. OBJECTIVE:To evaluate the efficacy and tolerance of systemic low-dose methotrexate (LD...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.3.263
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Recent epidemiologic studies have shown that environmental contaminants such as air pollution and tobacco smoke play an important role in the pathophysiology of atopic dermatitis (AD). OBJECTIVE:The aim of this study was to evaluate the relationship between the severity of AD and indoor air pollution. METH...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.3.292
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE:We evaluated the anti...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2014.26.5.584
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL), including sleep quality. OBJECTIVE:The purpose of this study was to evaluate the relationships between clinical disease severity, QOL and sleep quality in children and...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2016.28.3.321
更新日期：2016-06-01 00:00:00
abstract：:Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from ec...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S1.S79
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-term...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2011.23.2.138
更新日期：2011-05-01 00:00:00
abstract：:Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S3.S329
更新日期：2011-12-01 00:00:00
