Sox9 Increases the Proliferation and Colony-forming Activity of Outer Root Sheath Cells Cultured In Vitro.

Abstract:

BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-terminal truncated β-catenin (constitutive active form), and β-catenin-regulated genes were identified. RESULTS:Overexpression of the constitutively active form of β-catenin led to induction of Sox9 expression at both mRNA and protein levels. To investigate the potential role of Sox9, we made the recombinant adenovirus expressing green fluorescent protein-tagged Sox9, and then transduced into cultured ORS cells. Interestingly, Sox9 induced the expression of keratin 15, increased the proliferation of ORS cells in vitro, and enhanced colony-forming activity. CONCLUSION:Our results suggest that Sox9 is a β-catenin-regulated gene in ORS cells, and has potential importance in the regulation of hair follicle homeostasis.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Shi G,Sohn KC,Kim SY,Ryu EK,Park YS,Lee Y,Seo YJ,Lee JH,Kim CD

doi

10.5021/ad.2011.23.2.138

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

138-43

issue

2

eissn

1013-9087

issn

2005-3894

journal_volume

23

pub_type

杂志文章
  • Effect of probiotics on the treatment of children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.2.189

    authors: Yeşilova Y,Çalka Ö,Akdeniz N,Berktaş M

    更新日期:2012-05-01 00:00:00

  • Case of epidermolysis bullosa with pyloric atresia.

    abstract::Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). Recently, hemidesmosomal EB has been propo...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S41

    authors: Kim JH,Park HY,Lee HJ,Eom M,Choi EH

    更新日期:2011-09-01 00:00:00

  • Role of keratinocytes in the development of vitiligo.

    abstract::Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.2.115

    authors: Lee AY

    更新日期:2012-05-01 00:00:00

  • Interferon-alpha Induced Sarcoidosis with Cutaneous Involvement along the Lines of Venous Drainage.

    abstract::Sarcoidosis is a systemic inflammatory disease of an unknown origin and it is characterized by the presence of noncaseating epitheloid cell granulomas in multiple organs. Herein we report on a case of cutaneous and pulmonary sarcoidosis that was associated with interferon alpha treatment for hepatitis C. A 39-year-old...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.2.239

    authors: Lee YB,Lee JI,Park HJ,Cho BK,Oh ST

    更新日期:2011-05-01 00:00:00

  • Risk Factors Affecting Adverse Effects of Cyclosporine A in a Real-World Psoriasis Treatment.

    abstract:Background:No study to date has focused on the changes in laboratory test results and related risk factors in patients with psoriasis treated with prolonged Cyclosporine A (CsA) therapy. Objective:The objective of this study was to investigate the changes of laboratory values and related risk factors in patients with ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2018.30.2.143

    authors: Kim BR,Yang S,Doh EJ,Choi CW,Youn SW

    更新日期:2018-04-01 00:00:00

  • The clinical efficacy, safety and functionality of anion textile in the treatment of atopic dermatitis.

    abstract:BACKGROUND:Several previous studies have suggested the improvement of atopic dermatitis (AD) in response to special fabrics. In particular, beneficial effects have been reported, following the use of anion textiles. OBJECTIVE:The purpose of this study is to evaluate the effectiveness and safety of an anion textile in ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.4.438

    authors: Kim SH,Hwang SH,Hong SK,Seo JK,Sung HS,Park SW,Shin JH

    更新日期:2012-11-01 00:00:00

  • Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine.

    abstract:BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2017.29.2.143

    authors: Kim JM,Lim KM,Kim HS,Ko HC,Kim MB,Kim BS

    更新日期:2017-04-01 00:00:00

  • Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study.

    abstract:Background:Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD. Objective:The aim of this randomized, double-blinded, placebo...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2018.30.4.409

    authors: Chung BY,Park SY,Jung MJ,Kim HO,Park CW

    更新日期:2018-08-01 00:00:00

  • Localized Telogen Effluvium Following Hair Transplantation.

    abstract::Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, m...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2018.30.2.214

    authors: Loh SH,Lew BL,Sim WY

    更新日期:2018-04-01 00:00:00

  • Actinomycosis of the upper lip.

    abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S131

    authors: Lee YS,Sim HS,Lee SK

    更新日期:2011-09-01 00:00:00

  • Fibrin glue fixation for suction blister epidermal grafting in two patients with stable vitiligo.

    abstract::Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2014.26.6.751

    authors: Kim H,Kang JN,Hwang SH,Seo JK,Sung HS

    更新日期:2014-12-01 00:00:00

  • Identification of dermatophytes using multiplex polymerase chain reaction.

    abstract:BACKGROUND:Multiplex polymerase chain reaction (PCR) allows more than two target DNA molecules to be amplified with more than two primers. This method is also useful for detecting various other organisms simultaneously within a single test tube, and the scope of its use has been expanding widely in the field of clinica...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2011.23.3.304

    authors: Kim JY,Choe YB,Ahn KJ,Lee YW

    更新日期:2011-08-01 00:00:00

  • Touraine-soulente-golé syndrome: a rare case report and review of the literature.

    abstract::Touraine-Soulente-Golé Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspect...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2013.25.3.352

    authors: Kumar S,Sidhu S,Mahajan BB

    更新日期:2013-08-01 00:00:00

  • A case of focal acral hyperkeratosis.

    abstract::Focal acral hyperkeratosis (FAH) is a rare genodermatosis with an autosomal dominant pattern of inheritance; however, it may also be sporadic. FAH is characterized by late-onset crateriform keratotic papules, some coalescing into plaques, along the borders of the hands and feet. We herein report a case of FAH in a 47-...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.4.426

    authors: Lee EA,Kim HS,Kim HO,Park YM

    更新日期:2009-11-01 00:00:00

  • TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis.

    abstract:BACKGROUND:Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the init...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2015.27.2.128

    authors: Popadic S,Savic E,Markovic M,Ramic Z,Medenica L,Pravica V,Spuran Z,Trajkovic V,Popadic D

    更新日期:2015-04-01 00:00:00

  • COMP-angiopoietin 1 Gene Transfer Enhances Cutaneous Wound Healing by Promoting Angiogenesis.

    abstract:BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We exam...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2008.20.2.49

    authors: Kim YY,Kim YJ,Ku JK,Kim MY,Kim YI,Koh GY,Kim HO,Park YM

    更新日期:2008-06-01 00:00:00

  • Two Pilosebaceous Cysts with Apocrine Hidrocystoma in One Biopsy Site: A Spectrum of the Same Disease Process?

    abstract::A 28-year-old woman presented with multiple, asymptomatic, erythematous to bluish papules located on the chest. Histopathologically, three round, well defined cystic structures were seen on the upper and lower dermis. The first cyst was milia, the second was apocrine hidrocystoma and the other, largest cyst was an eru...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2008.20.1.11

    authors: Hwang SW,Cho KJ,Oh DJ,Lee D,Kim JW,Park SW

    更新日期:2008-03-01 00:00:00

  • Fluconazole induced fixed drug eruption.

    abstract::We report on a rare case of fluconazole induced fixed drug eruption in a 62-year old female patient. She was referred to our department for multiple erythematous itchy maculopatches on the face, neck, both upper arms, and trunk area, which had occurred over the previous 6 months. Her attending physician prescribed flu...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S1

    authors: Kim CY,Kim JG,Oh CW

    更新日期:2011-09-01 00:00:00

  • Expression of the c-Met Proteins in Malignant Skin Cancers.

    abstract:BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2011.23.1.33

    authors: Lee YJ,Kim DH,Lee SH,Kim DW,Nam HS,Cho MK

    更新日期:2011-02-01 00:00:00

  • Fexofenadine-induced urticaria.

    abstract::Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S3.S329

    authors: Lee SW,Byun JY,Choi YW,Myung KB,Choi HY

    更新日期:2011-12-01 00:00:00

  • Localized Sweet's Syndrome in an Irradiated Field.

    abstract::Sweet's syndrome is a reactive dermatosis characterized clinically by fever, leukocytosis, and multiple, erythematous, painful plaques. Histopathologic examination reveals a band-like dense dermal inflammatory infiltrate composed mainly of neutrophils with papillary dermal edema, and no features of vasculitis. We repo...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.3.300

    authors: Lee GY,Do MO,Kim SH,Choi HY,Myung KB,Choi YW

    更新日期:2009-08-01 00:00:00

  • Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2013.25.2.189

    authors: Cho HJ,Cho SI,Kim HO,Park CW,Lee CH

    更新日期:2013-05-01 00:00:00

  • Clinical and Histopathological Investigation of Seborrheic Keratosis.

    abstract:BACKGROUND:Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location. OBJECTIVE:The aim of this study was to analyze...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.2.152

    authors: Roh NK,Hahn HJ,Lee YW,Choe YB,Ahn KJ

    更新日期:2016-04-01 00:00:00

  • CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis.

    abstract::Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid de...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.2.186

    authors: Choi KW,Lee KY,Lee YK,Ku BS,Kim HS,Kim YH,Kim KH

    更新日期:2010-05-01 00:00:00

  • Dapsone Hypersensitivity Syndrome That Occurred during Treatment of Pediatric Patient with Erythema Elevatum Diutinum.

    abstract::Herein, we report a case of an 8-year-old girl with dapsone hypersensitivity syndrome (DHS) that occurred during the treatment of erythema elevatum diutinum. She had fever, gross hematuria, and malaise for three weeks after initiation of dapsone therapy. Five days after stopping dapsone treatment, she returned to the ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S3.S290

    authors: Kim GW,Park HJ,Kim HS,Kim SH,Ko HC,Kim BS,Kim MB

    更新日期:2011-12-01 00:00:00

  • Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth.

    abstract:BACKGROUND:Stress is a known cause of hair loss in many species. OBJECTIVE:In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS:Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of r...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.5.600

    authors: Shin H,Choi SJ,Cho AR,Kim DY,Kim KH,Kwon O

    更新日期:2016-10-01 00:00:00

  • Two cases of eosinophilic fasciitis.

    abstract::Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fa...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.1.81

    authors: Chun JH,Lee KH,Sung MS,Park CJ

    更新日期:2011-02-01 00:00:00

  • Correlation between Severity of Atopic Dermatitis and Sleep Quality in Children and Adults.

    abstract:BACKGROUND:The atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL), including sleep quality. OBJECTIVE:The purpose of this study was to evaluate the relationships between clinical disease severity, QOL and sleep quality in children and...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.3.321

    authors: Kong TS,Han TY,Lee JH,Son SJ

    更新日期:2016-06-01 00:00:00

  • Tumor Necrosis Factor Alpha Blocker-Induced Erythrodermic Sarcoidosis in with Juvenile Rheumatoid Arthritis: A Case Report and Review of the Literature.

    abstract::The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2017.29.1.74

    authors: Park SK,Hwang PH,Yun SK,Kim HU,Park J

    更新日期:2017-02-01 00:00:00

  • Erratum: ERRATUM.

    abstract::[This corrects the article on p. 217 in vol. 21.]. ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2009.21.3.335

    authors:

    更新日期:2009-08-01 00:00:00