Abstract:
:The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy and review previous studies of cutaneous sarcoidosis. A 6-year-old Korean girl who had been suffering from juvenile rheumatoid arthritis presented with generalized erythematous skin eruption involving more than about 90% of her body surface area. After 14 months of etanercept treatment, the new erythematous skin eruption had developed and progressed into generalized erythroderma. Exclusion of suspected co-medication had been performed based on medication history. She had no other systemic symptoms, and ophthalmologic and neurologic examinations were normal. Histopathologic findings of the skin lesion revealed diffuse non-caseating granulomatous infiltrates composed of epithelioid histiocytes with sparse lymphocytes involving the entire dermis. Periodic-acid-Schiff and acid-fast stains were negative, and acid-fast bacilli was not detected by polymerase chain reaction of the skin biopsy. Based on clinicopathologic findings, she was diagnosed with etanercept-induced sarcoidal granuloma. After discontinuation of the suspected agent, the lesions spontaneously disappeared.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Park SK,Hwang PH,Yun SK,Kim HU,Park Jdoi
10.5021/ad.2017.29.1.74subject
Has Abstractpub_date
2017-02-01 00:00:00pages
74-78issue
1eissn
1013-9087issn
2005-3894journal_volume
29pub_type
abstract:BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.2.189
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Several workers have found that Malassezia are capable of suppressing cytokine release and downregulating the phagocytic function of monocytes. But lipid-depleted Malassezia furfur (M. furfur) extracts have also been shown to induce increased production of TNF-alpha, IL-6 and IL-1beta in monocytes. We though...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.2.130
更新日期:2009-05-01 00:00:00
abstract::Sweet's syndrome is a reactive dermatosis characterized clinically by fever, leukocytosis, and multiple, erythematous, painful plaques. Histopathologic examination reveals a band-like dense dermal inflammatory infiltrate composed mainly of neutrophils with papillary dermal edema, and no features of vasculitis. We repo...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.3.300
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Patients with atopic dermatitis (AD) should be relatively well informed about the disorder to control their condition and prevent flare-ups. Thus far, there is no accurate information about the disease awareness levels and therapeutic behavior of AD patients. OBJECTIVE:To collect data on patients' knowledge...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.1.40
更新日期:2015-02-01 00:00:00
abstract::A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planu...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.5.636
更新日期:2014-10-01 00:00:00
abstract::Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp. ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.319
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL), including sleep quality. OBJECTIVE:The purpose of this study was to evaluate the relationships between clinical disease severity, QOL and sleep quality in children and...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.3.321
更新日期:2016-06-01 00:00:00
abstract::Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by several erythematous papules on the lower b...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.233
更新日期:2008-12-01 00:00:00
abstract::Non-tubecrulosis mycobacterium infections were increasingly reported either pulmonary or extrapulmonary in the past decades. In Taiwan, we noticed several reports about the soft tissue infections caused by rapid growing mycobacterium such as Mycobacterium abscessus, Mycobacterium chelonae, on newspaper, magazines, or ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.2.236
更新日期:2014-04-01 00:00:00
abstract::Although more than 90% of melanomas have cutaneous origins, melanomas sometimes present metastatically with no apparent primary lesion. A 62-year-old female presented with black pigmentation on her left thumbnail that had begun 2 years earlier and after the biopsy, she was diagnosed with malignant melanoma. Interestin...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S274
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:The extracellular matrix (ECM) produced by dermal fibroblasts supports skin structure, and degradation and/or reduced production of ECM are the main causes of wrinkle formation. OBJECTIVE:The aim of this study was to identify the active ingredient that enhances ECM production in dermal fibroblasts. METHODS...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.1.16
更新日期:2012-02-01 00:00:00
abstract::Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walki...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S239
更新日期:2011-10-01 00:00:00
abstract::This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discont...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S404
更新日期:2011-12-01 00:00:00
abstract::Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abd...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.2.219
更新日期:2010-05-01 00:00:00
abstract::Basal cell carcinoma (BCC), which frequently occurs in sun-exposed areas of the head and neck region, is the most common cutaneous malignancy. The nipple-areola complex (NAC) is an uncommon site for BCC to develop. BCCs in this region display more aggressive behavior and a greater potential to spread than when found i...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S201
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer and possesses various clinical features including translucency, ulceration, pigmentation, telangiectasia, and rolled borders. Accordingly, many cutaneous lesions can mimic BCCs and differential diagnosis is difficult. OBJECTIVE:To clarify the...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.4.431
更新日期:2014-08-01 00:00:00
abstract::A 70-year-old woman with an 8-year history of systemic sarcoidosis developed round, red-brown eruptions, with central atrophic lesions on her lower legs. The features of the biopsy specimen resembled those of necrobiosis lipoidica (NL), but although necrobiosis was present there were well-formed non-necrotizing granul...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2012.24.1.74
更新日期:2012-02-01 00:00:00
abstract::Sarcoidosis is a systemic inflammatory disease of an unknown origin and it is characterized by the presence of noncaseating epitheloid cell granulomas in multiple organs. Herein we report on a case of cutaneous and pulmonary sarcoidosis that was associated with interferon alpha treatment for hepatitis C. A 39-year-old...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.2.239
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo. OBJECTIVE:To investigate the b...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.4.427
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.1.18
更新日期:2009-02-01 00:00:00
abstract::Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are characterized by the T-cell immunophenotype. Here, we report the first Korean case of EBV-ass...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.5.618
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2011.23.1.33
更新日期:2011-02-01 00:00:00
abstract::Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.2.201
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:VitabridC12 is newly developed and composed of vitamin C and Vitabrid (lamellar, hydrated zinc oxide). OBJECTIVE:In this study, we aimed to investigate the effects of VitabridC12 on psoriasis and atopic dermatitis. METHODS:Mice with imiquimod-induced psoriasis or Dermatophagoides farinae-induced atopic der...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.5.548
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Progressive macular hypomelanosis is characterized by ill-defined, non-scaly, hypopigmented macules primarily on the trunk of the body. Although numerous cases of progressive macular hypomelanosis have been reported, there have been no clinicopathologic studies of progressive macular hypomelanosis in Korean ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.3.261
更新日期:2009-08-01 00:00:00
abstract::Herein, we report a case of an 8-year-old girl with dapsone hypersensitivity syndrome (DHS) that occurred during the treatment of erythema elevatum diutinum. She had fever, gross hematuria, and malaise for three weeks after initiation of dapsone therapy. Five days after stopping dapsone treatment, she returned to the ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S290
更新日期:2011-12-01 00:00:00
abstract::Touraine-Soulente-Golé Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspect...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2013.25.3.352
更新日期:2013-08-01 00:00:00
abstract:Background:Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD. Objective:The aim of this randomized, double-blinded, placebo...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2018.30.4.409
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is involved in the developmental and disease processes of various cells and tissues by modulating the Wnt pathway. OBJEC...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.1.79
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Surgical scars are crucial cosmetic problem, especially when in exposed areas such as the anterior neck following thyroidectomy. OBJECTIVE:To evaluate the impact of post-thyroidectomy scars on quality of life (QoL) of thyroid cancer patients and identify the relationship between scar characteristics and QoL...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.6.693
更新日期:2014-12-01 00:00:00