Abstract：
Background:No study to date has focused on the changes in laboratory test results and related risk factors in patients with psoriasis treated with prolonged Cyclosporine A (CsA) therapy. Objective:The objective of this study was to investigate the changes of laboratory values and related risk factors in patients with psoriasis treated with CsA in a real-world setting. Methods:Records of patients with psoriasis treated with CsA at an outpatient clinic were collected, and a Cox proportional hazards regression model was used. Results:Of the 128 patients included in this study, 28 patients (21.9%) showed laboratory test abnormalities over a mean medication period of 11.6 months. Older age (hazard ratio [HR], 1.174; 95% confidence interval [CI], 1.068~1.370; p=0.007) and pre-existing kidney disease (HR, 0.008; 95% CI, 0~0.205; p=0.001) significantly increased the risk of renal dysfunction. Male sex was the only significant risk factor for liver enzyme elevation (HR, 0.284; 95% CI, 0.081~0.784; p=0.026) and uric acid abnormality (HR, 0.048; 95% CI, 0~0.372; p=0.046). Conclusion:This is an in-depth analysis of laboratory changes and related risk factors in patients with psoriasis treated with CsA. Liver is the most commonly affected organ of CsA toxicity. Older age, male sex, and presence of kidney disease were risk factors associated with laboratory abnormality during CsA treatment.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Kim BR,Yang S,Doh EJ,Choi CW,Youn SWdoi
10.5021/ad.2018.30.2.143subject
Has Abstractpub_date
2018-04-01 00:00:00pages
143-149issue
2eissn
1013-9087issn
2005-3894journal_volume
30pub_type
杂志文章abstract：BACKGROUND:There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE:The purpose of our research was to isolate and meas...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2016.28.5.533
更新日期：2016-10-01 00:00:00
abstract：:Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fa...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.1.81
更新日期：2011-02-01 00:00:00
abstract：:Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who p...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2010.22.1.48
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE:This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS:A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All pati...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.4.371
更新日期：2015-08-01 00:00:00
abstract：:Melanocytic nevi are subject to change with age in both clinical and histopathologic findings. In 1991, Cho et al. first reported three cases of lobulated intradermal nevi and suggested their cases represented an unusual form of regressing melanocytic nevus. Herein we report four cases of lobulated intradermal nevus a...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.1.115
更新日期：2011-02-01 00:00:00
abstract：:Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases bec...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2015.27.4.431
更新日期：2015-08-01 00:00:00
abstract：:Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2015.27.3.315
更新日期：2015-06-01 00:00:00
abstract：:Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented wi...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2018.30.3.342
更新日期：2018-06-01 00:00:00
abstract：:Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenita...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.3.381
更新日期：2014-06-01 00:00:00
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journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.5.636
更新日期：2014-10-01 00:00:00
abstract：:Disseminated superficial porokeratosis (DSP) is a rare variant of porokeratosis, which is characterized histologically by cornoid lamella and clinically by central atrophy with elevated borders. DSP is usually associated with immunosuppressive states and hematopoietic malignancies, but rarely with malignancies of visc...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2008.20.4.193
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.2.143
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PAS...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.5.557
更新日期：2015-10-01 00:00:00
abstract：:The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2017.29.1.74
更新日期：2017-02-01 00:00:00
abstract：:Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, m...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2018.30.2.214
更新日期：2018-04-01 00:00:00
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journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.3.405
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-term...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2011.23.2.138
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier. OBJECTIVE:We examined whether kinetin induces skin barrier functions in vitro and in vivo. METHODS:To evaluate the efficacy of kinetin a...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.1.6
更新日期：2017-02-01 00:00:00
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journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S3.S404
更新日期：2011-12-01 00:00:00
abstract：:Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2010.22.1.119
更新日期：2010-02-01 00:00:00
abstract：:The Abbé-Estlander flap surgery is a cross-lip procedure that is valuable in repairing a defect on the lower lip using a full-thickness flap, consisting of the skin, muscle and mucosa, from the upper lip. As usefulness and practicality of the flap in reconstruction of lower lip surgical defects in Asian ethnicity have...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2017.29.2.210
更新日期：2017-04-01 00:00:00
abstract：:Focal acral hyperkeratosis (FAH) is a rare genodermatosis with an autosomal dominant pattern of inheritance; however, it may also be sporadic. FAH is characterized by late-onset crateriform keratotic papules, some coalescing into plaques, along the borders of the hands and feet. We herein report a case of FAH in a 47-...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.4.426
更新日期：2009-11-01 00:00:00
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journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2013.25.3.352
更新日期：2013-08-01 00:00:00
abstract：:[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...
journal_title：Annals of dermatology
pub_type： 已发布勘误
doi：10.5021/ad.2018.30.4.511
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location. OBJECTIVE:The aim of this study was to analyze...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2016.28.2.152
更新日期：2016-04-01 00:00:00
abstract：:A 70-year-old woman with an 8-year history of systemic sarcoidosis developed round, red-brown eruptions, with central atrophic lesions on her lower legs. The features of the biopsy specimen resembled those of necrobiosis lipoidica (NL), but although necrobiosis was present there were well-formed non-necrotizing granul...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2012.24.1.74
更新日期：2012-02-01 00:00:00
abstract：:Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.6.751
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We exam...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2008.20.2.49
更新日期：2008-06-01 00:00:00
abstract：:Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2012.24.2.115
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.2.189
更新日期：2013-05-01 00:00:00
