Abstract：
BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We examined the effect of Ang 1 on cutaneous wound healing. METHODS:Cartilage oligomeric matrix protein (COMP)-Ang 1 (Ade-COMP-Ang 1)- was intravenously injected to rats two days before surgery creating full-thickness wounds. The clinical wound healing rate and the number of vessels in the skin samples were evaluated on days 3, 7 and 14 post operation. RESULTS:At post-operation day 3, 7 and 14, the clinical wound healing rate was 38.3%, 59.4% and 92.1%, respectively, in the Ade-COMP-Ang 1-treated group, compared with 20.5%, 47.5% and 87.3%, respectively, in the Ade-LacZ-treated group. There were significant differences in the results of day 3 and day 7 between two groups (p<0.05). Histopathologically, the number of the vessels of the Ade-COMP-Ang 1-treated group was 73.7, 94.1 and 62.7 at day 3, 7 and 14, compared with that of the Ade-LacZ-treated group, 53.5, 83.9, and 56.9. The differences in the results of the two groups were statistically significant (p<0.05). CONCLUSION:These results indicate that Ade-COMP-Ang 1 therapy significantly accelerats wound healing by promoting angiogenesis. However, further study using Ade-COMP-Ang 1 gene therapy for chronic wounds in which the formation of new blood vessels is impaired is needed in the near future.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Kim YY,Kim YJ,Ku JK,Kim MY,Kim YI,Koh GY,Kim HO,Park YMdoi
10.5021/ad.2008.20.2.49subject
Has Abstractpub_date
2008-06-01 00:00:00pages
49-55issue
2eissn
1013-9087issn
2005-3894journal_volume
20pub_type
杂志文章abstract：:Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum ...
journal_title：Annals of dermatology
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doi：10.5021/ad.2012.24.3.345
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abstract：BACKGROUND:Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. OBJECTIVE:Novel vehicles for topical glucocorticoids formulation were ev...
journal_title：Annals of dermatology
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abstract：:Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor of mesenchymal origin. It is rarer than osseous osteosarcoma and there are very few reports of the skin being a primary site. Most reported cutaneous ESOS were accompanied with metastasis in other organs. A 56-year-old man presented with a painful, 1.5×0...
journal_title：Annals of dermatology
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abstract：BACKGROUND:Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo. OBJECTIVE:To investigate the b...
journal_title：Annals of dermatology
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abstract：:Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented wi...
journal_title：Annals of dermatology
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abstract：:Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...
journal_title：Annals of dermatology
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abstract：BACKGROUND:Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier. OBJECTIVE:We examined whether kinetin induces skin barrier functions in vitro and in vivo. METHODS:To evaluate the efficacy of kinetin a...
journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
pub_type： 杂志文章
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journal_title：Annals of dermatology
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doi：10.5021/ad.2008.20.2.98
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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doi：10.5021/ad.2013.25.2.237
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journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2008.20.3.146
更新日期：2008-09-01 00:00:00
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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journal_title：Annals of dermatology
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