Abstract:
BACKGROUND:The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries. However, the precise mechanism of its inhibitory effect on melanogenesis is not fully understood. OBJECTIVE:In order to clarify the inhibitory effect of tranexamic acid on PIH, we investigated its effects on mouse melanocytes (i.e., melan-a cells) and human melanocytes. METHODS:Melan-a cells and human melanocytes were cultured with fractional CO2 laser-treated keratinocyte-conditioned media. Melanin content and tyrosinase activity were evaluated in cells treated with or without tranexamic acid. Protein levels of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were evaluated in melan-a cells. Signaling pathway molecules involved in melanogenesis in melanoma cells were also investigated. RESULTS:Tranexamic acid-treated melanocytes exhibited reduced melanin content and tyrosinase activity. Tranexamic acid also decreased tyrosinase, TRP-1, and TRP-2 protein levels. This inhibitory effect on melanogenesis was considered to be involved in extracellular signal-regulated kinase signaling pathways and subsequently microphthalmia-associated transcription factor degradation. CONCLUSION:Tranexamic acid may be an attractive candidate for the treatment of PIH.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Kim MS,Bang SH,Kim JH,Shin HJ,Choi JH,Chang SEdoi
10.5021/ad.2015.27.3.250subject
Has Abstractpub_date
2015-06-01 00:00:00pages
250-6issue
3eissn
1013-9087issn
2005-3894journal_volume
27pub_type
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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