Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.

Abstract:

:Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, and other causes. So far, only a few cases of IgA bullous dermatosis coexisting with IgA nephropathy have been reported. A 64-year-old female receiving intravenous ceftriaxone and metronidazole for liver abscess had purpuric macules and papules on her extremities. One week later, she had generalized edema and skin rash with bullae and was diagnosed with concurrent linear IgA dermatosis and IgA nephropathy. After steroid treatment, the skin lesion subsided within two weeks, and kidney function slowly returned to normal. As both diseases occurred after a common possible cause, we predict their pathogeneses are associated.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Kim JS,Choi M,Nam CH,Kim JY,Park BC,Kim MH,Hong SP

doi

10.5021/ad.2015.27.3.315

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

315-8

issue

3

eissn

1013-9087

issn

2005-3894

journal_volume

27

pub_type

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