Abstract:
:Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid dendritic cell precursor. Cases of HN that completely lack CD4 or CD56 expression, therefore represents a diagnostic problem. A 68-year-old Korean male was diagnosed with CD4-/CD56+ HN and treated with hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone) at initial treatment, and then switched to high dose methotrexate/cytarabine. His disease relapsed and resulted in death from bone and brain disease 6 months after complete clinical remission, despite diagnostic workups, including a radioisotope liver scan and ultrasound-guided fine needle aspiration biopsy. Further cytogenetic studies such as comparative genomic hybridization could elucidate the genetic mechanisms in the development and progression of lymphomas. We report an unusual case of 'CD4-/CD56+/CD123+ HN' showing early liver metastasis.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Choi KW,Lee KY,Lee YK,Ku BS,Kim HS,Kim YH,Kim KHdoi
10.5021/ad.2010.22.2.186subject
Has Abstractpub_date
2010-05-01 00:00:00pages
186-90issue
2eissn
1013-9087issn
2005-3894journal_volume
22pub_type
abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S131
更新日期:2011-09-01 00:00:00
abstract::Lichen aureus is a rare type of chronic pigmented purpuric dermatosis. The eruptions consist of discrete or confluent golden to brownish lichenoid macules and papules, and are usually asymptomatic. Lichen aureus commonly occurs in young adults, but less frequently in children. We report the first case of multiple lich...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.4.393
更新日期:2009-11-01 00:00:00
abstract::Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from ec...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S79
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE:It w...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.4.470
更新日期:2016-08-01 00:00:00
abstract::Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by several erythematous papules on the lower b...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.233
更新日期:2008-12-01 00:00:00
abstract::Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.2.115
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE:To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS:...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.6.711
更新日期:2016-12-01 00:00:00
abstract::Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walki...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S239
更新日期:2011-10-01 00:00:00
abstract::Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp. ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.319
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.6.709
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.1.18
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Gray hair naturally develops in the process of human aging. Many people with gray hair periodically dye their hair. Hair dyeing products are widely used and they can cause adverse effects. Therefore, the user's knowledge and recognition about hair dyeing and related side effects are important. OBJECTIVE:The...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.3.274
更新日期:2012-08-01 00:00:00
abstract:Background:Prevalence of subungual melanoma (SUM) in Asian population is relatively high and early clinical detection improves both quality of life and survival. Objective:We sought to establish screening strategy for SUM in situ. Methods:We retrospectively reviewed medical records of 8 patients pathologically diagno...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2018.30.1.36
更新日期:2018-02-01 00:00:00
abstract::Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases bec...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2015.27.4.431
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE:This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS:A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All pati...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.4.371
更新日期:2015-08-01 00:00:00
abstract::Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2012.24.3.345
更新日期:2012-08-01 00:00:00
abstract::Although more than 90% of melanomas have cutaneous origins, melanomas sometimes present metastatically with no apparent primary lesion. A 62-year-old female presented with black pigmentation on her left thumbnail that had begun 2 years earlier and after the biopsy, she was diagnosed with malignant melanoma. Interestin...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S274
更新日期:2011-10-01 00:00:00
abstract::Clinically, folliculosebaceous cystic hamartoma (FSCH) lacks distinct features, but it has been reported as an asymptomatic, 1- to 3-cm, dome-shaped nodule on the face. Histopathologically, FSCH is characterized by adnexal and folliculosebaceous cystic proliferation with various mesenchymal changes. This case presente...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.1.63
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.2.189
更新日期:2013-05-01 00:00:00
abstract::We report on a rare case of fluconazole induced fixed drug eruption in a 62-year old female patient. She was referred to our department for multiple erythematous itchy maculopatches on the face, neck, both upper arms, and trunk area, which had occurred over the previous 6 months. Her attending physician prescribed flu...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S1
更新日期:2011-09-01 00:00:00
abstract::This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discont...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S404
更新日期:2011-12-01 00:00:00
abstract::Acantholytic squamous cell carcinoma is a well-defined variant of squamous cell cancer in which significant portions of the neoplastic proliferation show a pseudoglandular or tubular microscopic pattern. It usually presents as a nodule with various colors, and it is accompanied by scaling, crusting, and ulceration on ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.267
更新日期:2008-12-01 00:00:00
abstract::Leiomyosarcomas are uncommon malignant smooth muscle tumors, mainly derived from vessels or viscera. Superficial leiomyosarcomas are a rare soft tissue sarcoma arising from the dermis or subcutaneous tissue in the skin. According to tumor origin and location, they are divided into cutaneous and subcutaneous leiomyosar...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2013.25.2.237
更新日期:2013-05-01 00:00:00
abstract::Hydroa vacciniforme (HV) is a photosensitivity disorder characterized by recurrent necrotic vesiculopapules on sun-exposed areas, which heal spontaneously during adolescence. Recently, an association has been reported between latent Epstein-Barr virus (EBV) infection and atypical HV-like eruption and malignant potenti...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.2.209
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the init...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.2.128
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. OBJECTIVE:The aim of this study was to de...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2010.22.4.412
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE:The aim of this study i...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2010.22.3.255
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The extracellular matrix (ECM) produced by dermal fibroblasts supports skin structure, and degradation and/or reduced production of ECM are the main causes of wrinkle formation. OBJECTIVE:The aim of this study was to identify the active ingredient that enhances ECM production in dermal fibroblasts. METHODS...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.1.16
更新日期:2012-02-01 00:00:00
abstract::Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious f...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.3.327
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Stress is a known cause of hair loss in many species. OBJECTIVE:In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS:Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of r...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.5.600
更新日期:2016-10-01 00:00:00