Progressive macular hypomelanosis in korean patients: a clinicopathologic study.

Abstract:

BACKGROUND:Progressive macular hypomelanosis is characterized by ill-defined, non-scaly, hypopigmented macules primarily on the trunk of the body. Although numerous cases of progressive macular hypomelanosis have been reported, there have been no clinicopathologic studies of progressive macular hypomelanosis in Korean patients. OBJECTIVE:In this study we examined the clinical characteristics, histologic findings, and treatment methods for progressive macular hypomelanosis in a Korean population. METHODS:Between 1996 and 2005, 20 patients presented to the Department of Dermatology at Busan Paik Hospital with acquired, non-scaly, confluent, hypopigmented macules on the trunk, and with no history of inflammation or infection. The medical records, clinical photographs, and pathologic findings for each patient were examined. RESULTS:The patients included 5 men and 15 women. The mean age of onset was 21.05+/-3.47 years. The back was the most common site of involvement. All KOH examinations were negative. A Wood's lamp examination showed hypopigmented lesions compared with the adjacent normal skin. A microscopic examination showed a reduction in the number of melanin granules in the lesions compared with the adjacent normal skin, although S-100 immunohistochemical staining did not reveal significant differences in the number of melanocytes. Among the 20 patients, 7 received topical drug therapy, 6 were treated with narrow-band ultraviolet B phototherapy, 4 received oral minocycline, and 3 did not receive any treatment. CONCLUSION:Most of the patients with progressive macular hypomelanosis had asymptomatic ill-defined, non-scaly, and symmetric hypopigmented macules, especially on the back and abdomen. Histologically, the number of melanocytes did not differ significantly between the hypopigmented macules and the normal perilesional skin. No effective treatment is known for progressive macular hypomelanosis; however, narrow-band ultraviolet B phototherapy may be a useful treatment modality.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Hwang SW,Hong SK,Kim SH,Park JH,Seo JK,Sung HS,Lee D

doi

10.5021/ad.2009.21.3.261

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

261-7

issue

3

eissn

1013-9087

issn

2005-3894

journal_volume

21

pub_type

杂志文章
  • A survey of the awareness, knowledge and behavior of hair dye use in a korean population with gray hair.

    abstract:BACKGROUND:Gray hair naturally develops in the process of human aging. Many people with gray hair periodically dye their hair. Hair dyeing products are widely used and they can cause adverse effects. Therefore, the user's knowledge and recognition about hair dyeing and related side effects are important. OBJECTIVE:The...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.3.274

    authors: Kim JE,Jung HD,Kang H

    更新日期:2012-08-01 00:00:00

  • Sox9 Increases the Proliferation and Colony-forming Activity of Outer Root Sheath Cells Cultured In Vitro.

    abstract:BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-term...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2011.23.2.138

    authors: Shi G,Sohn KC,Kim SY,Ryu EK,Park YS,Lee Y,Seo YJ,Lee JH,Kim CD

    更新日期:2011-05-01 00:00:00

  • A case of childhood lichen aureus.

    abstract::Lichen aureus is a rare type of chronic pigmented purpuric dermatosis. The eruptions consist of discrete or confluent golden to brownish lichenoid macules and papules, and are usually asymptomatic. Lichen aureus commonly occurs in young adults, but less frequently in children. We report the first case of multiple lich...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.4.393

    authors: Kim MJ,Kim BY,Park KC,Youn SW

    更新日期:2009-11-01 00:00:00

  • A case of giant folliculosebaceous cystic hamartoma.

    abstract::Clinically, folliculosebaceous cystic hamartoma (FSCH) lacks distinct features, but it has been reported as an asymptomatic, 1- to 3-cm, dome-shaped nodule on the face. Histopathologically, FSCH is characterized by adnexal and folliculosebaceous cystic proliferation with various mesenchymal changes. This case presente...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.1.63

    authors: Haw S,Lee MH

    更新日期:2009-02-01 00:00:00

  • The short stature in atopic dermatitis patients: are atopic children really small for their age?

    abstract:BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2013.25.1.23

    authors: Park MK,Park KY,Li K,Seo SJ,Hong CK

    更新日期:2013-02-01 00:00:00

  • Blastomycosis-like Pyoderma with Good Response to Acitretin.

    abstract::Blastomycosis-like pyoderma is a rare, vegetating skin lesion that is an unusual exaggerated tissue reaction possibly to prolonged primary or secondary bacterial infection. We report a case of blastomycosis-like pyoderma in a man with Down syndrome, diabetes mellitus and hypothyroidism who responsed poorly to conventi...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.3.365

    authors: Lee YS,Jung SW,Sim HS,Seo JK,Lee SK

    更新日期:2011-08-01 00:00:00

  • The Appearance of a Candidate Site for a Primary Melanoma: A 5 Year-gap with a Melanoma of an Unknown Site.

    abstract::Although more than 90% of melanomas have cutaneous origins, melanomas sometimes present metastatically with no apparent primary lesion. A 62-year-old female presented with black pigmentation on her left thumbnail that had begun 2 years earlier and after the biopsy, she was diagnosed with malignant melanoma. Interestin...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S2.S274

    authors: Lee S,Lee HJ,Oh SH,Im M,Lee JH,Seo YJ,Lee Y

    更新日期:2011-10-01 00:00:00

  • Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers.

    abstract:BACKGROUND:Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier. OBJECTIVE:We examined whether kinetin induces skin barrier functions in vitro and in vivo. METHODS:To evaluate the efficacy of kinetin a...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2017.29.1.6

    authors: An S,Cha HJ,Ko JM,Han H,Kim SY,Kim KS,Lee SJ,An IS,Kim S,Youn HJ,Ahn KJ,Kim SY

    更新日期:2017-02-01 00:00:00

  • A Case of Epstein-Barr Virus-associated Hydroa Vacciniforme.

    abstract::Hydroa vacciniforme (HV) is a photosensitivity disorder characterized by recurrent necrotic vesiculopapules on sun-exposed areas, which heal spontaneously during adolescence. Recently, an association has been reported between latent Epstein-Barr virus (EBV) infection and atypical HV-like eruption and malignant potenti...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.2.209

    authors: Huh SY,Choi M,Cho KH

    更新日期:2009-05-01 00:00:00

  • Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model.

    abstract:BACKGROUND:Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE:This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma), Aminexil, Dercos (Vic...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.1.65

    authors: Orasan MS,Bolfa P,Coneac A,Muresan A,Mihu C

    更新日期:2016-02-01 00:00:00

  • Correlation between Severity of Atopic Dermatitis and Sleep Quality in Children and Adults.

    abstract:BACKGROUND:The atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL), including sleep quality. OBJECTIVE:The purpose of this study was to evaluate the relationships between clinical disease severity, QOL and sleep quality in children and...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.3.321

    authors: Kong TS,Han TY,Lee JH,Son SJ

    更新日期:2016-06-01 00:00:00

  • A case of complication after matridex(r) injection.

    abstract::Matridex(R) is an injectable skin filler that's composed of a mixture of cross linked hyaluronic acid and dextranomer particles, and it was recently developed for soft tissue augmentation. To the best of our knowledge, there have been few previous reports on complications associated with Matridex. We report here on a ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.1.81

    authors: Huh SY,Cho S,Kim KH,An JS,Won CH,Chang SE,Lee MW,Choi JH,Moon KC

    更新日期:2010-02-01 00:00:00

  • Eccrine porocarcinoma presenting with unusual clinical manifestations: a case report and review of the literature.

    abstract::Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from ec...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S79

    authors: Choi CM,Cho HR,Lew BL,Sim WY

    更新日期:2011-09-01 00:00:00

  • Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation.

    abstract:BACKGROUND:Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE:To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS:...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.6.711

    authors: Ryu HJ,Lee JM,Jang HW,Park HC,Rhyu IJ,Kim IH

    更新日期:2016-12-01 00:00:00

  • A case of lymphomatoid keratosis.

    abstract::Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abd...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.2.219

    authors: Choi MJ,Kim HS,Kim HO,Song KY,Park YM

    更新日期:2010-05-01 00:00:00

  • Impact of postthyroidectomy scar on the quality of life of thyroid cancer patients.

    abstract:BACKGROUND:Surgical scars are crucial cosmetic problem, especially when in exposed areas such as the anterior neck following thyroidectomy. OBJECTIVE:To evaluate the impact of post-thyroidectomy scars on quality of life (QoL) of thyroid cancer patients and identify the relationship between scar characteristics and QoL...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2014.26.6.693

    authors: Choi Y,Lee JH,Kim YH,Lee YS,Chang HS,Park CS,Roh MR

    更新日期:2014-12-01 00:00:00

  • Enhancement of keratinocyte differentiation by rose absolute oil.

    abstract:BACKGROUND:Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE:The aim of this study i...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2010.22.3.255

    authors: Kim JH,Choi DK,Lee SS,Choi SJ,Kim CD,Yoon TJ,Lee JH

    更新日期:2010-08-01 00:00:00

  • Two cases of unilateral lichen planus following the lines of blaschko.

    abstract::A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planu...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2014.26.5.636

    authors: Yayla D,Külcü Çakmak S,Oğuz ID,Gönül M,Ozhamam E,Colak A,Gül U

    更新日期:2014-10-01 00:00:00

  • Deep penetrating benign fibrous histiocytoma of the foot associated with throbbing pain.

    abstract::Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walki...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S2.S239

    authors: Chung J,Namkoong S,Sim JH,Lee JS,Hong SP,Kim MH,Park BC

    更新日期:2011-10-01 00:00:00

  • Fibrin glue fixation for suction blister epidermal grafting in two patients with stable vitiligo.

    abstract::Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2014.26.6.751

    authors: Kim H,Kang JN,Hwang SH,Seo JK,Sung HS

    更新日期:2014-12-01 00:00:00

  • Disseminated Superficial Porokeratosisin a Patient with Gastric Cancer.

    abstract::Disseminated superficial porokeratosis (DSP) is a rare variant of porokeratosis, which is characterized histologically by cornoid lamella and clinically by central atrophy with elevated borders. DSP is usually associated with immunosuppressive states and hematopoietic malignancies, but rarely with malignancies of visc...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2008.20.4.193

    authors: Kim SW,Min SU,Won CH,Cho S

    更新日期:2008-12-01 00:00:00

  • Intravascular cytotoxic T-cell lymphoma in a young immunocompetent woman.

    abstract::Intravascular lymphoma (IVL) is a rare disorder characterized by the presence of large neoplastic lymphoid cells restricted to the lumens of small vessels with a predilection for the skin and the central nervous system. While the vast majority of cases involving IVL are of B-cell lineage, the disease rarely affects th...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2014.26.4.496

    authors: Jang YH,Lee SJ,Choi YH,Lee WJ,Kim DW,Kim J,Park TI,Chae YS

    更新日期:2014-08-01 00:00:00

  • Congenital and multiple hobnail hemangiomas.

    abstract::Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.4.539

    authors: Yoon SY,Kwon HH,Jeon HC,Lee JH,Cho S

    更新日期:2011-11-01 00:00:00

  • Expression of sfrp2 is increased in catagen of hair follicles and inhibits keratinocyte proliferation.

    abstract:BACKGROUND:Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is involved in the developmental and disease processes of various cells and tissues by modulating the Wnt pathway. OBJEC...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2014.26.1.79

    authors: Kim BK,Yoon SK

    更新日期:2014-02-01 00:00:00

  • Role of keratinocytes in the development of vitiligo.

    abstract::Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.2.115

    authors: Lee AY

    更新日期:2012-05-01 00:00:00

  • Actinomycosis of the upper lip.

    abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S131

    authors: Lee YS,Sim HS,Lee SK

    更新日期:2011-09-01 00:00:00

  • Atrophying pityriasis versicolor: is this a new variant of pityriasis versicolor?

    abstract::An atypical clinical form of pityriasis versicolor has been infrequently reported, in which cutaneous atrophy is associated with individual pityriasis versicolor lesions. The pathogenesis of this atrophy remains unclear, but is believed to be a delayed-type hypersensitivity reaction to antigens derived from the Malass...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.4.456

    authors: Yang YS,Shin MK,Haw CR

    更新日期:2010-11-01 00:00:00

  • Cutaneous extraskeletal osteosarcoma on the scar of a previous bone graft.

    abstract::Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor of mesenchymal origin. It is rarer than osseous osteosarcoma and there are very few reports of the skin being a primary site. Most reported cutaneous ESOS were accompanied with metastasis in other organs. A 56-year-old man presented with a painful, 1.5×0...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S2.S160

    authors: Park SG,Song JY,Song IG,Kim MS,Shin BS

    更新日期:2011-10-01 00:00:00

  • Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.

    abstract::Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2015.27.3.315

    authors: Kim JS,Choi M,Nam CH,Kim JY,Park BC,Kim MH,Hong SP

    更新日期:2015-06-01 00:00:00

  • Soft Tissue Infection Caused by Rapid Growing Mycobacterium following Medical Procedures: Two Case Reports and Literature Review.

    abstract::Non-tubecrulosis mycobacterium infections were increasingly reported either pulmonary or extrapulmonary in the past decades. In Taiwan, we noticed several reports about the soft tissue infections caused by rapid growing mycobacterium such as Mycobacterium abscessus, Mycobacterium chelonae, on newspaper, magazines, or ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2014.26.2.236

    authors: Lin SS,Lee CC,Jang TN

    更新日期:2014-04-01 00:00:00